Real-world use of ustekinumab therapeutic drug monitoring in moderate to severe psoriasis.

Introduction: There is growing evidence that therapeutic drug monitoring of biologic therapy is beneficial in psoriatic patients. With respect to ustekinumab, the available evidence has not shown any relationship yet. The objective of this study is to identify correlations among ustekinumab trough concentrations, anti-ustekinumab antibodies and clinical response in moderate-to-severe plaque psoriasis patients, in a real-world setting.

[Detection of alpha-1 antitrypsin deficiency: A study on patients diagnosed with chronic obstructive pulmonary disease in primary health care].

The prevalence of chronic obstructive pulmonary disease (COPD) in Spain is 10.2%. Although tobacco is the main aetiological factor, biomass smoke exposure and alpha-1 antitrypsin deficiency (AATD) have also been related to its development.

[Health care quality perceived by the patients in an urban health centre in A Coruña].

Objective: The aim of this study is to explore the reliability and validity of the adapted questionnaire SERVPERF in primary care and to obtain a measure of perceived quality from the patient point of view in an urban health centre.

Method: A cross-sectional descriptive study.

Participants: One in five of all the patients who visited the health centre during one week in March 2010 were systematically selected until completing the required sample size.

Validity and reliability of the SF-36 questionnaire in patients on the waiting list for a kidney transplant and transplant patients.

Background/aims: The aim of this study is to explore the validity and reliability of the health-related quality of life SF-36 questionnaire in patients undergoing renal replacement therapy.

Methods: A multicenter descriptive transversal study was carried out in Galicia, Spain, with patients undergoing renal replacement therapy. The tool used to measure the health-related quality of life was the authorized Spanish version of the 'SF-36' generic health questionnaire.

Factors leading to the removal of the intrauterine implant Gynefix.

Objective: The objective of this study was to determine the incidence of expulsion of the Gynefix intrauterine implant, to analyze the variables associated with the above and to examine the efficacy of this intrauterine contraceptive model in users at the Municipal Family Planning Center-SERGAS in A Coruña, Spain.

Methods: A prospective observational study was performed on all women (n = 358) who had a Gynefix implant inserted from March 1998 to September 2000.

Results: The accumulated incidence of implant expulsion was 6.

The importance of the removal of the intrauterine device in genital colonization by actinomyces.

Objective: To determine whether, in addition to treatment with antibiotics, it is necessary to remove the intrauterine device (IUD) to eliminate genital colonization by Actinomyces.

Methods: A randomized clinical trial was carried out. Patients were divided into two groups.

Eight years with the same IUD.

The purpose of this study was to determine the efficacy of the TCu380A (GYNET 380 IUD) in long-term users for periods of > 5 years and to obtain the incidence of Actinomyces as related to length of use and reasons for removal. The report is a retrospective descriptive study of all the clinical cases (n = 370 patients) at the Municipal Family Planning Centre-SERGAS A Coruña, Spain, of women who had a TCu380A IUD inserted during the period 1988-1989 with a September 1997 cutoff date for data analysis. A total of 271 (73.