Indobufen versus aspirin in patients with indication for antiplatelet therapy: A systematic review and meta-analysis.

Introduction: Aspirin is commonly recommended for individuals who have experienced stroke or myocardial infarction (MI). Indobufen, a cyclooxygenase-1 inhibitor, has been studied as a potential alternative. We conducted a meta-analysis and trial sequential analysis (TSA) to compare indobufen with aspirin in patients requiring antiplatelet therapy.

Addressing Gearbox Health Monitoring Challenges for Helicopters: A Machine Learning Approach.

The transmission gearbox of military helicopters, such as the H225M, experiences intense dynamic loads, leading to the detachment of ferromagnetic particles, often due to wear or fatigue. This poses safety risks, as excessive particle detachment demands stringent maintenance. To address this, the study applies machine learning algorithms to predict particle detachment using data from the Flight Data Recorder and Health and Usage Monitoring System.

Chemical and sensorial profile of cultivars fermented by different post-harvest processing methods.

Climatic conditions, genotypes, and post-harvest processing methods influence coffee quality. Microbial fermentation during post-harvest processing has sparked researchers' interest due to the modulation of the sensory characteristics of coffee. However, the influence of microbial fermentation on different coffee genotypes has been little investigated.

Cardiotoxic and Cardioprotective Effects of Methylene Blue in the Animal Model of Cardiac Ischemia and Reperfusion.

Treatment of patients with myocardial ischemic diseases crucially involves cardiac reperfusion (CR). However, oxidative stress and tissue lesions caused by CR may also lead to lethal complications, such as arrythmias and vasoplegic syndrome (VS). Although methylene blue (MB) has long been used to treat VS due to cardiac ischemia and reperfusion (CIR) and/or surgery because of its vascular effects, MB's effects on the heart are unclear.

Warfarin and Aspirin Versus Warfarin Alone in Patients With HeartMate 3 Left Ventricular Assist Device: A Systematic Review and Meta-Analysis.

Background And Aims: HeartMate 3 (HM3), a fully magnetically levitated ventricular assist device (LVAD), has been associated with reduced thromboembolic events compared to HeartMate II. However, bleeding events remained significant. Among patients undergoing HM3 implantation, the standard antithrombotic regimen comprises both warfarin and aspirin (ASA), but there is a lack of evidence on the optimum antithrombotic therapy.

Incidence of aortic valve reintervention in patients with aortic stenosis undergoing transcatheter aortic valve implantation versus surgical aortic valve replacement: a systematic review and updated meta-analysis of randomized studies.

Introduction: Transcatheter aortic valve implantation (TAVI) and surgical aortic valve replacement (SAVR) are established interventions for alleviating symptoms and enhancing survival in individuals with severe aortic stenosis (AS). However, the long-term outcomes and incidence of reintervention associated with TAVI and SAVR remain uncertain.

Methods: We conducted a systematic review and meta-analysis to compare the incidence of reintervention in TAVI versus SAVR.

Distal versus traditional radial access in patients undergoing emergency coronary angiography or percutaneous coronary intervention: a systematic review and meta-analysis.

Background: Distal radial access (DRA) is a well-tolerated and effective alternative to traditional radial access (TRA) for coronary procedures. However, the comparative value of these modalities remains unknown in the emergency setting, particularly in patients with ST-elevation myocardial infarction (STEMI).

Objective: To compare DRA versus TRA for emergency coronary procedures through a meta-analysis.

Analysis of functionality, pain and quality of life after surgically treated ankle fractures in active and inactive individuals.

Although the ankle is often involved in low energy trauma, high-energy trauma may occur, being this considered more serious and more common of affecting young and active men. The purpose of the present study was to evaluate and compare the functionality, pain and quality of life of active and inactive adult individuals whose ankle fracture was surgically treated. Seventy-six patients split into two groups (active, n = 58 X inactive, n = 18), of the men (active, n = 38; inactive, n = 9) and women (active, n = 20; inactive, n = 9) gender participated in this prospective study.

Graph Theoretical Description of Phase Transitions in Complex Multiscale Phases with Supramolecular Assemblies.

Phase transitions are typically quantified using order parameters, such as crystal lattice distances and radial distribution functions, which can identify subtle changes in crystalline materials or high-contrast phases with large structural differences. However, the identification of phases with high complexity, multiscale organization and of complex patterns during the structural fluctuations preceding phase transitions, which are essential for understanding the system pathways between phases, is challenging for those traditional analyses. Here, it is shown that for two model systems- thermotropic liquid crystals and a lyotropic water/surfactant mixtures-graph theoretical (GT) descriptors can successfully identify complex phases combining molecular and nanoscale levels of organization that are hard to characterize with traditional methodologies.

Relationship between periapical lesions and sinus changes on multi-slice computed tomography sean.

Unlabelled: Differentiating orofacial odontogenic pain/disorders from pain/disorders associated with maxillary sinusitis is important to avoid unnecessary dentalprocedures and to properly refer patients to colleagues/dentists and vice versa.

Aim: To analyze the association between apical lesions and sinus changes and to evaluate the agreement between the diagnoses of an endodontist, a radiologist, an oral and maxillofacial surgeon, and an otolaryngologist.

Materials And Method: 385 axial, coronal, and sagittal MSCT scans were selected using an image archiving andcommunication system (PACS).

Nanosized Water Channels Associated with Hydrophobic and Hydrophilic Fibrillar Arrangements Formed on Nafion Surfaces in Confined Regions.

Herein, the origin of interfacial water nanosized channel distributions attached onto Nafion surfaces is investigated. The surface fibrillary hydrophilic and hydrophobic arrangements were observed on AFM images scanned on Nafion surfaces immersed in water. Then, by analyzing the force vs separation curves, it is possible to map arrays of interfacial water channels and their locations.

Pleonotoquinones, Cytotoxic Oxepinenaphthoquinones from .

Two unusual naphthoquinones, named here as pleonotoquinones A () and B (), were isolated along with two known anthraquinones ( and ) via chromatographic separations of an ethyl acetate extract of the roots of . Compounds and are the first examples of quinones bearing a 2-methyloxepine moiety. The compounds were isolated with the aid of mass spectrometry and molecular networking, and their structures were resolved using 1D and 2D NMR and HRESIMS data.

Association Between Body Mass Index, Obesity, and Clinical Outcomes Following Coronary Artery Bypass Grafting in Brazil: An Analysis of One Year of Follow-up of BYPASS Registry Patients.

Objective: To investigate the association between body mass index (BMI), obesity, clinical outcomes, and mortality following coronary artery bypass grafting (CABG) in Brazil using a large sample with one year of follow-up from the Brazilian Registry of Cardiovascular Surgeries in Adults (or BYPASS) Registry database.

Methods: A multicenter cohort-study enrolled 2,589 patients submitted to isolated CABG and divided them into normal weight (BMI 20.0-24.

Cardiotoxic Effects Produced by Omeprazole and Methylene Blue in an Animal Model of Cardiac Ischemia and Reperfusion and Potential Implications for the Pharmacological Strategy for Vasoplegic Syndrome.

Defined as systemic hypotension caused by intense vasodilation due to the loss of systemic vascular resistance, vasoplegic syndrome (VS) is associated with elevated morbidity and mortality in humans. Although vasopressors such as norepinephrine and vasopressin are the first-choice drugs for VS treatment, several other drugs such as methylene blue (MB) can be used as adjuvant therapy including rescue therapy. To develop new pharmacological strategies to reduce the risk of VS, we investigated the effects of treatments with MB (2 mg/kg/IV), omeprazole (OME, 10 mg/kg/IV), and their combination in an animal model of cardiac ischemia-reperfusion (CIR).

Aquatic exercise for people with asthma: a systematic review with meta-analysis of randomized controlled trials.

Introduction: Aquatic exercises are among the types of exercise most tolerated by people with asthma. Therefore, the objective of this study was to synthesize the evidence on the effects of aquatic exercise on lung function and quality of life in asthmatic patients.

Data Sources: A systematic search encompassing the Medline, CINAHL, Cochrane Library, Embase, AMED, SPORTDiscus, and Physiotherapy Evidence Database databases was conducted to identify randomized controlled trials assessing the impact of aquatic exercise in comparison to control conditions or land-based exercise on lung function and quality of life in individuals diagnosed with asthma.

Fibrillary Arrangement of Elongated, Almost Parallel Aggregates of Hydrophobic and Hydrophilic Domains Forming the Nafion Surface Structure Improved Contrast Atomic Force Microscopy Images.

A significant improvement in spatial resolution is reported in Nafion surface maps when compared to previous atomic force microscopy images of the Nafion surface scanned in air. The technique ability is to generate maps showing approximately few nanometer (∼2-5 nm) patterns to the long fiber length (>2 μm). Atomic force microscopy force vs separation curve profiles registered in water are used to characterize the surface hydrophobic and hydrophilic domains.