Twenty-year experience in liver surgery in metastatic colorectal patients: a case series study in Ukraine.

Unlabelled: For the last three decades, the world surgical community successfully adopted different surgical strategies for colorectal cancer (CRC) patients with liver metastases (LM), however, we are still seeing the evolution of treatment guidelines. The purpose of the study was to analyze a 20-year evolution of CRC patients with LM being treated in a specialized state Ukrainian oncological center.

Materials And Methods: The retrospective analysis of 1118 CRC patient cases using prospectively collected patient data from the National Cancer Institute registry.

Comparison of ultrasound and MRI informativeness for detection and treatment monitoring of cervical cancer metastases in the vagina.

Aim: To assess ultrasound (US) method informativeness in the recurrence detection and treatment monitoring of patients with cervical cancer metastases in the vagina via comparing the US and magnetic resonance imaging (MRI) data.

Materials And Methods: 42 patients with recurrence of cervical cancer were examined by transvaginal US and MRI. Data on radiation diagnostics of cervical cancer metastasis in the vagina were compared with pathomorphological data.

Texture Analysis of Tumor and Peritumoral Tissues Based on 18F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography Hybrid Imaging in Patients With Rectal Cancer.

Objective: This study aimed to determine whether texture parameters could be used in differentiation between the tumor and the peritumoral tissues based on hybrid 18F-Fluorodeoxyglucose positron emission tomography/computed tomography imaging for patients with rectal cancer.

Methods: Seven parameters, including heterogeneity, entropy, energy, skewness, kurtosis, standard deviation, and average brightness, were extracted from positron emission tomography/computed tomography scans of 22 patients (12 male and 10 female; mean age, 61 ± 2 years).

Results: The peritumoral tissue had a significantly lower value of the heterogeneity parameter (23%) than the tumor.

Efficacy of Combination Neoadjuvant Chemotherapy and Regional Inductive Moderate Hyperthermia in the Treatment of Patients With Locally Advanced Breast Cancer.

Purpose: To evaluate the efficacy of neoadjuvant chemotherapy in combination with regional inductive moderate hyperthermia for patients with locally advanced breast cancer.

Patients And Methods: 200 patients with stage IIB-IIIA breast cancer received neoadjuvant chemotherapy (control group, n = 97) or chemotherapy combined with hyperthermia (experimental group, n = 103). Inductive hyperthermia was set at 27.

The role of carbonic anhydrase α-CA4 in the adaptive reactions of photosynthetic apparatus: the study with α-CA4 knockout plants.

The role of α-carbonic anhydrase 4 (α-CA4) in photosynthetic machinery functioning in thylakoid membranes was studied, using Arabidopsis thaliana wild type plants (WT) and the plants with knockout of At4g20990 gene encoding α-CA4 (αCA4-mut) grown both in low light (LL, 80 μmol quanta m s) or in high light (HL, 400 μmol quanta m s). It was found that a content of PsbS protein, one of determinants of non-photochemical quenching of chlorophyll fluorescence, increased in mutants by 30% and 100% compared with WT plants in LL and in HL, respectively. Violaxanthin cycle pigments content and violaxanthin deepoxidase activity in HL were also higher in αCA4-mut than in WT plants.

Radiation research to determine local tumor invasion in patients with cervical cancer.

Unlabelled: The main task of radiation study of verified cervical cancer (CC) is tumor spread assessment because of its profound effect on the treatment tactics choice and prognosis. The Aim of the study was radiation study optimizing for tumor local spread assessment in patients with CC via comparing the usefulness of different magnetic resonance imaging (MRI) based approaches.

Materials And Methods: 62 patients with CC were examined by MRI on tomograph 1.

Seasonal variations of leaf chlorophyll-protein complexes in the wintergreen herbaceous plant Ajuga reptans L.

The chlorophyll and carotenoid content, and the spectra of low-temperature fluorescence of the leaves, chloroplasts and isolated pigment-protein complexes in the perennial herbaceous wintergreen plant Ajuga reptans L. (bugle) in different seasons of the year were studied. During winter, these plants downregulate photosynthesis and the PSA is reorganised, including the loss of chlorophyll, possible reductions in the number of functional reaction centres of PSII, and changes in aggregation of the thylakoid protein complexes.

Expression profiles of genes for mitochondrial respiratory energy-dissipating systems and antioxidant enzymes in wheat leaves during de-etiolation.

Mitochondrial respiratory components participate in the maintenance of chloroplast functional activity. This study investigates the effects 48h de-etiolation of spring wheat seedlings (Triticum aestivum L., var.

[Tropisms in underground shoots — stolons and rhizomes].

In the review, the problem of plant movements (photo- and gravitropism) is discussed. The contemporary data on physiological and molecular mechanisms of tropisms in underground shoots and roots are presented. Special attention is paid to diagravitropism phenomenon in underground shoots (stolons and rhizomes) that grow in perpendicular direction to the Earth's gravitational axis.

Photosynthetic activity of vascular bundles in Plantago media leaves.

Photosynthetic processes in the leaf lamina and midribs of Plantago media were investigated using plants grown in high light (HL) or low light (LL) conditions. The fluorescence parameters, which indicate photochemical/photosynthetic activity, were different in HL and LL grown plants, but no major differences between lamina and midribs were found. An OJIP test (chlorophyll a fluorescence transient induction) of LL grown plants, indicative of the chloroplast electron transport chain, also showed both tissues to be similar.

[SYNDROMAL APPROACH IN ULTRASONOGRAPHIC DIAGNOSIS OF THORACIC TRAUMA].

Diagnosis of the thoracic organs injuries constitute an actual problem of modern medicine. Results of examination of 96 injured persons, suffering thoracic cavity organs trauma, were analyzed. Ultrasonographic investigation conduction in complex with radiological methods, basing on syndromal diagnostic approach, have permitted to enhance diagnostic informativity significantly, to obtain objective data about character of the injury, and to establish adequate tactics of treatment for the injured persons, basing on analysis of the results achieved.

Intraoperative ultrasonography in pancreatic surgery: staging and resection guidance.

Background: Intraoperative ultrasound examination (IOUS) is indispensable part of modern surgical interventions in tumors of hepatopancreatobiliary zone. In this study retrospective analysis of IOUS efficiency in surgical treatment of pancreatic tumors was provided.

Materials And Methods: In the period from January 2013 till November 2015 in the National Cancer Institute IOUS was applied during 76 surgical interventions: for pancreatic head tumors--in 46 (60.

Traits of Heracleum sosnowskyi Plants in Monostand on Invaded Area.

The ability of giant hogweeds to form monodominant communities and even pure monostands in invaded areas has been well documented. Understanding of the mechanisms leading to monostand formation can aid in determining the limitations of existing community ecology models and establishing an effective management plan for invasive species elimination. The aim of this observational study was to investigate traits of Heracleum sosnowskyi plants (demography, canopy structure, morphology and physiology) of the plants in a pure stand in an invaded area useful for understanding potential monostand formation mechanisms.

Use of elastography for cervical cancer diagnostics.

Unlabelled: The aim of the study was to investigate the use of elastography for cervical cancer diagnostics.

Materials And Methods: The ultrasonic study with use of sonoelastography involved 87 patients with cervical pathology (cervicitis, n = 11; dysplasia, n = 14; cervical cancer, n = 62).

Results: At non-malignant pathology elastic types of elastograms prevailed while the tumors were characterized by images of stiff type formations.

Light regulation of mitochondrial alternative oxidase pathway during greening of etiolated wheat seedlings.

This study deals with effects of de-etiolation (48h) of spring wheat (Triticum aestivum L., var. Irgina) seedlings on differential expression of AOX1 genes, levels of AOX protein and the alternative respiratory pathway (AP) capacity.

Control of Inhibition by the Direct Action of Cannabinoids on GABAA Receptors.

Cannabinoids are known to regulate inhibitory synaptic transmission via activation of presynaptic G protein-coupled cannabinoid CB1 receptors (CB1Rs). Additionally, recent studies suggest that cannabinoids can also directly interact with recombinant GABAA receptors (GABAARs), potentiating currents activated by micromolar concentrations of γ-aminobutyric acid (GABA). However, the impact of this direct interaction on GABAergic inhibition in central nervous system is unknown.

[Use of ion-exchange substrates for optimizing the mineral supply to plants within life support systems].

The main goal of the work is to validate ion-exchange substrates as optimizers of plant mineral supply within bio-engineering systems of life support with a high level of closure. Test objects were spring Lisovsky wheat-232 and leaf cabbage Sensuji-kyomizuna. Crops were cultivated on artificial soil (AS) in environmentally controlled plant growth chambers.

Treatment of large osteosarcoma in children: new approach.

Aim: To improve the treatment results of patients with locally advanced osteosarcoma with large volume using neoadjuvant chemotherapy (NACT) (ifosfamide at a dose of 18 g/ml) and planning of organ-conserving surgery by evaluating the state of tumor pseudocapsule.

Patients And Methods: A study group included 46 children aged from 7 to 18 years, mean age - 12 years. In 68% of the patients tumor volume was larger or significantly larger than 200 ml (from 27 to 2400 ml), mean tumor volume was 342 ml.

[Polar lipid pool modification in leaves of hoary plantain (Plantago media L.) plants during their light adaptation under natural conditions].

Polar glycerolipids and photosynthetic pigments of Plantago media L. plants, growing on limestone outcrops of the Southern Timan, have been studied. Leaves of plants growing on well insolated and heated slopes are characterized by an intensive lipoperoxidation; the accumulation of chlorophylls and carotenoids in these plants is 1.

An Approximation to the Adaptive Exponential Integrate-and-Fire Neuron Model Allows Fast and Predictive Fitting to Physiological Data.

For large-scale network simulations, it is often desirable to have computationally tractable, yet in a defined sense still physiologically valid neuron models. In particular, these models should be able to reproduce physiological measurements, ideally in a predictive sense, and under different input regimes in which neurons may operate in vivo. Here we present an approach to parameter estimation for a simple spiking neuron model mainly based on standard f-I curves obtained from in vitro recordings.

[Optimization of the mineral nutrition of plants constituting the phototrophic component of closed biological life support systems].

Applicability of a new substrate for crops cultivation in bioregenerative LSSs with a high degree of mass-exchange closure was tested. Optimization of leaf cabbage nutrition by supplementing the basic substrate fabricated of plant and animal residues with ion-exchange resins proved to have a success.

Photoprotection by carotenoids of Plantago media photosynthetic apparatus in natural conditions.

The study of daily changes in photosynthetic rate, of energy used in photochemical and non-photochemical processes, and of carotenoid composition aimed at evaluating the role of xanthophyll cycle (XC) in protection of hoary plantain plants (Plantago media) in nature. The leaves of sun plants differed from shade plants in terms of CO(2) exchange rate and photosynthetic pigments content. The total pool XC pigments and the conversion state increased from morning to midday in sun plants.

Seasonal changes of violaxanthin cycle pigment de-epoxidation in wintergreen and evergreen plants.

We studied carotenoids composition and the activities of the xanthophylls pigments in evergreen conifers (Abies sibirica, Juniperus communis, Picea obovata) and dwarf-shrub (Vaccinium vitis-idaea), and in wintergreen herbaceous plants (Ajuga reptans, Pyrola rotundifolia) growing near Syktyvkar (61°67(/) N 50°77(/) E). The carotenoid pool consisted mainly of following xanthophylls: lutein (70%), neoxanthin (7-10%) and a xanthophylls cycle component - violaxanthin (3-15%). Zeaxanthin and antheraxanthin were found in conifer samples collected in December-March while in other species - during all year.

[Comparative evaluation of productivity of several green cultures as potential higher plant components of bio-regenerative systems of life support].

Purpose of the investigation was to select, analyze and evaluate green plant species known for assisting resistance to diseases and improving physiological functions in humans, and to test allelopathic compatibility of selected species with basic systems for life support. Nutrient substrates were freshly made soil-like substrate (SLS) and clayite. Green cultures were 6 spinach species, 2 lettuces, 2 leaf cabbage species and ruccola.

Fast homeostatic plasticity of inhibition via activity-dependent vesicular filling.

Synaptic activity in the central nervous system undergoes rapid state-dependent changes, requiring constant adaptation of the homeostasis between excitation and inhibition. The underlying mechanisms are, however, largely unclear. Chronic changes in network activity result in enhanced production of the inhibitory transmitter GABA, indicating that presynaptic GABA content is a variable parameter for homeostatic plasticity.