[The evaluation of efficiency of the project "Home Patronage" in Moscow].

In Moscow, the improvement of primary health care home support of patients with limited mobility is implemented since 2017, through the new organizational form "The primary health care support of groups of population with limited mobility" - "Patronage at home". In this regard, the "evaluation of performance efficiency" of this novation is of particular importance. The purpose of the study was to substantiate approaches to implementation of such an assessment applying developed with consideration of experts' opinions "The system of criteria and indices" as well as using the data of registry of patients in need of home patronage.

[Monitoring of bacterial contamination of water reservoirs in the Rostov region].

The paper estimates the epidemic value of indicators for microbial contamination of waters from their main supply sources (waters from the Tsimlyansk Reservoir and the Nizhni Don River and drinking waters from the towns of Azov and Tsimlyansk) in the Rostov Region. The Tsimlyansk Reservoir water met the SanPiN 2.1.

[The health characteristics of the population dwelling the northern territories].

The role of the latitudinal gradient in the deepening of the regional differentiation of population health and in the effectiveness of the medical care organization is considered. The analysis of the actual trends in mortality, morbidity and medical aid appealability in the context of the three singled out groups of the Russian Federation subjects is given. The latitudinal differentiation of the basic public health indicators and their dependency on the resource supply and the workload of health care system is demonstrated.

[Significance of indicator microorganisms in the assessment of a microbial risk in the occurrence of epidemic hazard in drinking water use].

Summary. The paper provides comparative characteristics of water quality in the assessment of a risk for intestinal infections in drinking water use. It has shown that of the greatest predictive value is direct detection of potentially pathogenic microorganisms, as well as the integral indicator determined by glucose fermentation, such as glucose-positive coliform bacteria.

[Liquid accumulation medium for isolation of Salmonella from water bodies].

The paper presents the data of experimental and field studies into the efficiency of Salmonella isolation from differently bacterial-contaminated water, by employing 3 storage media. It shows the benefits of using the test medium versus the storage (magnesium and selenite) media commonly applied by practical laboratories. The content of Salmonella in the biotopes of varying biological contamination is shown.

[Base for use a new liquid accumulation growth medium for the isolation of Salmonella from water objects].

Base for use of new luquid mild inhibitory accumulation medium for the isolation of Salmonella from water objects has been proposed. High sensitivity and efficacy of the new medium compared with routinely used magnesium and selenitic media were shown in experimental conditions. During examination of water from surface reservoirs the new accumulation medium allowed to isolate Salmonella with higher index and various serologic patterns.

[Problems of epidemic safety of drinking water use by the population of Russia].

Quantitative relationships were studied between the indicators (common coliform bacteria (CCP), glucose-positive bacteria (GPB), thermoduric bacteria (TDB), coliform bacteria, enterococci, clostridia, coliphages) and the opportunistic (Pseudomonas aeruginosa, Proteus, Klebsiella) and pathogenetic (Salmonella and intestinal viruses) microorganisms at the stages of effluent purification and decontamination, in processes of self-purification in the water reservoirs and of water preparation at water-supplying stations, as well as in the association with the incidence of acute intestinal infections of bacterial and viral genesis in different climatic zones of the country. Salmonella and the opportunistic bacteria of the Enterobacteriaceae family and Pseudomonas aeruginosa were found to be highly resistant to detoxifying agents and environmental factors, adaptable, able to reproduce in pure water, to long survive in underground waters, and to accumulate when water is desalinated at the erections. The cases of intestinal infections were found in the population using the portable water of the standard quality in terms of E.

[Effects of water use conditions on cancer morbidity].

The study demonstrated that the cancer situation is tense in the Tsimlyansk area and it can be referred to a high malignant tumor morbidity and mortality zone. The sources of water supply of populated localities may be involved in the formation of malignant tumor morbidity rates.

[Barrier role of water-purifying construction of water pipe in relation to opportunistic microorganisms].

The investigations have indicated that in the flood period when the water-purifying means of a water pipe bears the maximum load, the existing water-preparing system cannot fully purify and disinfect drinking water from some opportunistic microbes (Klebsiella, Acinetobacter). The latter were recorded in the pipe water having the MAC of coliform organisms established by the GOST.

[A comparative pharmacological study of the serotoninergic antidepressants tetrindole and fluoxetin].

Tetrindol, a selective inhibitor of MAOA (predominantly of serotonin oxidase) and fluoxetine, an inhibitor of serotonin neuronal uptake, were studied in psychotropic tests on mice and rats. Both drugs significantly intensified 5-hydroxytriptophan-induced head twitching, reduced the effect of reserpine and the destructive action of maximal electroshock and the scopalamine-induced transient disruption of memory in a test for conditioned response of passive avoidance in rats and mice. In a behavioral swimming test the drugs were less active.

[Effect of sanitary and hygienic conditions of populated placed on the incidence of intestinal diseases].

Data on the relationship between the incidence of intestinal infections, including hepatitis A, and communal conditions of settlements and quality of drinking water are presented.

Monoamine oxidase inhibition by novel antidepressant tetrindole.

The novel antidepressant tetrindole (2,3,3a,4,5,6-hexahydro-8-cyclohexyl-1H[3,2,1-j,k] carbazole) was found to be a selective inhibitor of monoamine oxidase A (MAO A). In vitro it inhibited rat brain mitochondrial MAO A in a competitive manner with Ki value of 0.4 microM.

[The new antidepressant tetrindole].

The antidepressive effects of tetrindole versus pyrazidole (pirlindole) and imipramine were studied in animal experiments. Tetrindole was found to be more active than pyrazidole and imipramine in a behavioral model of Porsolt, in antagonism with reserpine, in potentiation with 5-hydroxytryptophan, L-dopa and clonidine. The action of terindole is related to its ability to exert reversible inhibitory effects on MAO A activity.

[Anticalcium activity of several antidepressive agents].

In experiments in white mice and rats the antidepressants pyrazidol (pirlindole), moclobemide and especially tetrindole possess anticalcium activity in tests of calcium chloride-induced lethality in mice and arrhythmia in rats. Tetrindole is as active as verapamil. Imipramine, azaphen and incazane were not active in these experiments.

[The antiamnesic properties of antidepressants].

The experiments on albino rats demonstrated that antidepressants pyrazidol, imipramine, incazane, moclobemide and to a lesser degree azaphen reduce the amnesic effects of electroshock and scopolamine in the rats with the acquired conditioned reaction of passive avoidance. The studied antidepressants decrease also the disturbing action of alcohol on the learning of rats of the conditioned reaction of active avoidance.

[Effects of antidepressive agents on tolerance of hypoxia and physical exercise].

In experiments on mice and rats we studied the influence of antidepressants on hypoxic and physical tolerance. The antidepressants pyrazidol, azaphen, imipramine and moclobemide as well as the nootropic drug piracetam prolonged the life of animals in conditions of hypoxic and hemic hypoxia and increased the survival rate of rats in circulatory hypoxia. In experiments on mice antidepressants increased also the time of swimming.

[The comparative influence of pyrazidol, inkazan and other antidepressant monoamine oxidase inhibitors on the pressor effect of tyramine].

In experiments on conscious normotensive male Wistar rats the new antidepressants, reversible MAO-A inhibitors, pyrazidole and incazane, as well as moclobemid increased the pressor effect of orally administered tyramine. The drugs potentiated also the pressor effect of intravenous tyramine. More prolonged potentiation of tyramine action was produced by moclobemid, less prolonged by incazane.

[The influence of the Soviet antidepressants pyrazidol and inkazan on the effects of clonidine].

The influence of Soviet-made antidepressants pyrazidol and incazane on some clonidine-induced effects (hypolocomotion, reactions of synchronization and desynchronization in the EEG, aggression) were studied. Pyrazidol and incazane reduce the effects of low doses of clonidine--the hypolocomotor one and the synchronization reaction in the EEG and enhance the effects of a high dose of clonidine--aggression and the desynchronization reaction in the EEG. The reduction of the sedative effects of clonidine as well as the enhancement of its activating effects by antidepressants can reflect the activation of adrenergic transmission by them.

["Despair" and "escape" behavioral tests in the evaluation of antidepressant activity].

Antidepressants pyrazidol (pirlindole), incazan, imipramine, nialamide, nomifensine, mianserin were shown to reduce the duration of immobilization in mice in "despair" tests and increase the number of rotations in water "escape" tests.

[Effect of antidepressants on the convulsive action of thiosemicarbazide, strychnine and corasol].

Orally administered amitryptiline (25 and 50 mg/kg) protected animals against fatal convulsions induced by thiosemicarbazide, strychnine and metrazole. Vilaxazine had a protecting effect against death induced by strychnine. Impramine, maprotiline, mianserine and pirlindole (pyrazidol) only somewhat prolonged the latend period of convulsions and death, while incazane, caroxazone, nomifenzine and trazodone had practically no effect on the action of the three convulsants under study.