Cell-autonomous adaptation: an overlooked avenue of adaptation in human evolution.

Adaptation to environmental conditions occurs over diverse evolutionary timescales. In multi-cellular organisms, adaptive traits are often studied in tissues/organs relevant to the environmental challenge. We argue for the importance of an underappreciated layer of evolutionary adaptation manifesting at the cellular level.

Increased cardiovascular risk in people with LADA in comparison to type 1 diabetes and type 2 diabetes: Findings from the DPV registry in Germany and Austria.

Introduction: We aimed to characterise and compare individuals diagnosed with type 1 diabetes (T1D), latent autoimmune diabetes in adults (LADA) and type 2 diabetes (T2D), in a real-world setting.

Methods: Anthropometric and clinical data from 36 959 people with diabetes diagnosed at age 30-70 years enrolled in the prospective diabetes patients follow-up (DPV) registry from 1995 to 2022 were analysed cross-sectionally at diagnosis and follow-up (≥6 months after diagnosis). LADA was defined as clinical diagnosis of T2D, positivity of ≥1 islet autoantibody and an insulin-free interval of ≥6 months upon diabetes diagnosis.

Comprehensive Behavioral (ComB) Treatment of Trichotillomania: A Randomized Clinical Trial.

Objective: This study is the first controlled trial of comprehensive behavioral (ComB) treatment of trichotillomania (TTM). ComB provides individualized treatment based on factors triggering and maintaining hair pulling.

Method: Participants (N = 36) were adults (M = 34.

Comprehensive Behavioral Treatment of Trichotillomania: A Treatment Development Study.

This study aimed to concretize and pilot test comprehensive behavioral (ComB) treatment of trichotillomania (TTM), to facilitate rigorous testing of its efficacy. ComB provides a conceptualization to develop individualized treatment and choose interventions for managing distinct factors that maintain the individual's hair pulling. It has been used by clinicians for almost three decades, yet was not previously manualized or studied empirically.

Inositol stereoisomers stabilize an oligomeric aggregate of Alzheimer amyloid beta peptide and inhibit abeta -induced toxicity.

Inositol has 8 stereoisomers, four of which are physiologically active. myo-Inositol is the most abundant isomer in the brain and more recently shown that epi- and scyllo-inositol are also present. myo-Inositol complexes with Abeta42 in vitro to form a small stable micelle.

Trichotillomania: a comprehensive behavioral model.

As our knowledge of chronic hair pulling as neither rare nor benign has increased, so has the need for a comprehensive framework to guide our conceptualization of this disorder for both research and clinical work. Such a model is presented which incorporates (a) the varied antecedents that both cue the impulse to pull and facilitate pulling, (b) the wide array of behaviors involved in the actual pulling, and (c) the full range of consequences of pulling. The cyclical nature of pulling episodes is highlighted.