Publications by authors named "Golnaz Roshankar"
Article Synopsis
- A systematic review and meta-analysis were conducted to assess the accuracy of different bone scintigraphy imaging techniques for diagnosing transthyretin cardiac amyloidosis (ATTR-CM), revealing shifts in accuracy over time.* -
- Out of 428 studies, 23 were selected for analysis, encompassing 3,954 patients, with 39.6% diagnosed with ATTR-CM; visual planar grading and quantitative analysis showed higher accuracy than the heart-to-contralateral (HCL) ratio.* -
- The findings indicate that bone scintigraphy is highly effective for diagnosing ATTR-CM, with variability in study results largely due to differing disease prevalence, and highlight the need for precise methods in low-risk populations.*
Background: Quantitation of myocardial Tc-pyrophosphate activity may have high diagnostic accuracy, but its correlation with disease burden is unknown. We examined the relationship between Tc-pyrophosphate quantitation and cardiac magnetic resonance (CMR) measures in patients with suspected transthyretin cardiac amyloidosis (ATTR-CM) or light chain cardiac amyloidosis (AL-CM).
Methods: Consecutive patients who underwent Tc-pyrophosphate imaging and CMR were included.
We studied the interaction of Aspirin (acetylsalicylic acid) with lipid membranes using x-ray diffraction for bilayers containing up to 50 mol% of aspirin. From 2D x-ray intensity maps that cover large areas of reciprocal space we determined the position of the ASA molecules in the phospholipid bilayers and the molecular arrangement of the molecules in the plane of the membranes. We present direct experimental evidence that ASA molecules participate in saturated lipid bilayers of DMPC (1,2-dimyristoyl-sn-glycero-3-phosphocholine) and preferably reside in the head group region of the membrane.
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