Assessment of Left Lung Remodeling With Magnetic Resonance Imaging in a Murine Model Following Exposure to Douglas Fir Smoke.

Wildland firefighters (WLFFs) experience lung function decline due to occupational exposure to fire smoke. WLFFs typically do not wear respiratory personal protective equipment, and if they do, it is a simple bandana, which is not effective at filtering smoke. To pinpoint the biological underpinnings of abnormal respiratory function following 3-7 years of WLFF service, we exposed mice to Douglas fir smoke (DFS) over 8 weeks.

2D and 3D Erosion Landscape Analysis of Endodontic-Treated Teeth Using EDTA and HEDP as Chelating Agents: A High-Resolution Micro-Computed Tomographic Study.

This study aimed to assess the amount of erosion during activated endodontic irrigation with either HEDP or EDTA via high-resolution micro-computed tomography. Two root canals of twenty premolars were prepared with ProTaper Next and irrigated with sodium hypochlorite. Palatal canals, which served as control groups, were sealed, while buccal canals were further irrigated with either EDTA (n = 10) or HEDP (n = 10), which served as test groups.

Prolonged smoldering Douglas fir smoke inhalation augments respiratory resistances, stiffens the aorta, and curbs ejection fraction in hypercholesterolemic mice.

While mounting evidence suggests that wildland fire smoke (WFS) inhalation may increase the burden of cardiopulmonary disease, the occupational risk of repeated exposure during wildland firefighting remains unknown. To address this concern, we evaluated the cardiopulmonary function in mice following a cumulative exposure to lab-scale WFS equivalent to a mid-length wildland firefighter (WLFF) career. Dosimetry analysis indicated that 80 exposure hours at a particulate concentration of 22 mg/m yield in mice the same cumulative deposited mass per unit of lung surface area as 3600 h of wildland firefighting.

Digital transformation: analog expertise and digital optimization.

Digital tools now enable an effective and efficient workflow even for complex implant-prosthetic restorations such as the immediate restoration of the edentulous maxilla. Planning predictability due to high process reliability, time saving, cost reduction due to shortened therapy sequences, high patient satisfaction due to predictable results, and high patient comfort are the advantages of the digitally supported therapy phases - from digital volume tomography of the bony structures to planning software to CAD/CAM-generated temporaries and prototypes to all-ceramic restorations. However, the use of digital procedures and techniques alone is no guarantee for a successful, indication-appropriate, and patient-specific restoration.

Effects of Natural and Forced Entrainment on PM Emissions from Fire Whirls.

The influence of different air entrainment conditions on the emissions of particulate matter from fire whirls was investigated by igniting a diesel fuel pool, 0.7 m in diameter, within a four-walled enclosure. Four different natural entrainment conditions resulted when gap sizes in the walls were varied between 0.

Effect of moisture content and fuel type on emissions from vegetation using a steady state combustion apparatus.

Emission measurements are available in the literature for a wide variety of field burns and laboratory experiments, although previous studies do not always isolate the effect of individual features such as fuel moisture content (FMC). This study explores the effect of FMC on gaseous and particulate emissions from flaming and smouldering combustion of four different wildland fuels found across the United States. A custom linear tube-heater apparatus was built to steadily produce emissions in different combustion modes over a wide range of FMC.

The German Restructured Vocal Fatigue Index and Characteristics of Dysphonic and Vocally Healthy Populations.

Objective: The Vocal Fatigue Index (VFI), a 19-item psychometric self-report questionnaire, enables individuals with vocal fatigue (VF) to be identified and their complaints to be characterized. The purpose of this study was to improve the German-language version (VFI-G) and to evaluate further vocal fatigue-related characteristics of dysphonic and control populations.

Methods: The VFI-G was restructured by replacing the three factors that structured the original: (1) tiredness of voice and voice avoidance; (2) physical discomfort; and (3) improvement of symptoms with rest, with two clusters developed on the basis of the results of a factor analysis by Nanjundeswaran et al.

NOX2ko Mice Show Largely Increased Expression of a Mutated NOX2 mRNA Encoding an Inactive NOX2 Protein.

Background: The superoxide-generating enzyme nicotinamide adenine dinucleotide phosphate (NADPH) oxidase (NOX2 or gp91phox, the phagocytic isoform) was reported as a major source of oxidative stress in various human diseases. Genetic deletion is widely used to study the impact of NOX2-derived reactive oxygen species (ROS) on disease development and progression in various animal models. Here, we investigate why NOX2 knockout mice show no NOX2 activity but express NOX2 mRNA and protein.

[A conventional three-unit bridge in the esthetic area].

In the prosthetic treatment planning there is an important question either you will have an surgery procedure or you will solve the requirement with a conventional treatment. It requires the discussion with the patient of all different parameters like risk factors in the pink - and white esthetic, condition of the adjacent teeth, outcome, long-term stability, costs, etc. In consideration of all facts a decision must be made of which adequate therapy is feasible.

Role of Firebrand Combustion in Large Outdoor Fire Spread.

Large outdoor fires are an increasing danger to the built environment. Wildfires that spread into communities, labeled as Wildland-Urban Interface (WUI) fires, are an example of large outdoor fires. Other examples of large outdoor fires are urban fires including those that may occur after earthquakes as well as in informal settlements.

Proceedings of the First Workshop Organized by the IAFSS Working Group on Measurement and Computation of Fire Phenomena (MaCFP).

This paper provides a report of the discussions held at the first workshop on Measurement and Computation of Fire Phenomena (MaCFP) on June 10-11 2017. The first MaCFP work-shop was both a technical meeting for the gas phase subgroup and a planning meeting for the condensed phase subgroup. The gas phase subgroup reported on a first suite of experimental- computational comparisons corresponding to an initial list of target experiments.

Summary of Workshop Large Outdoor Fires and the Built Environment.

Large outdoor fires present a risk to the built environment. Wildfires that spread into communities, referred to as Wildland-Urban Interface (WUI) fires, have destroyed communities throughout the world, and are an emerging problem in fire safety science. Other examples are large urban fires including those that have occurred after earthquakes.

Live cell X-ray imaging of autophagic vacuoles formation and chromatin dynamics in fission yeast.

Seeing physiological processes at the nanoscale in living organisms without labeling is an ultimate goal in life sciences. Using X-ray ptychography, we explored in situ the dynamics of unstained, living fission yeast Schizosaccharomyces pombe cells in natural, aqueous environment at the nanoscale. In contrast to previous X-ray imaging studies on biological matter, in this work the eukaryotic cells were alive even after several ptychographic X-ray scans, which allowed us to visualize the chromatin motion as well as the autophagic cell death induced by the ionizing radiation.

A self-filling microfluidic device for noninvasive and time-resolved single red blood cell experiments.

Existing approaches to red blood cell (RBC) experiments on the single-cell level usually rely on chemical or physical manipulations that often cause difficulties with preserving the RBC's integrity in a controlled microenvironment. Here, we introduce a straightforward, self-filling microfluidic device that autonomously separates and isolates single RBCs directly from unprocessed human blood samples and confines them in diffusion-controlled microchambers by solely exploiting their unique intrinsic properties. We were able to study the photo-induced oxygenation cycle of single functional RBCs by Raman microscopy without the limitations typically observed in optical tweezers based methods.

From fire whirls to blue whirls and combustion with reduced pollution.

Fire whirls are powerful, spinning disasters for people and surroundings when they occur in large urban and wildland fires. Whereas fire whirls have been studied for fire-safety applications, previous research has yet to harness their potential burning efficiency for enhanced combustion. This article presents laboratory studies of fire whirls initiated as pool fires, but where the fuel sits on a water surface, suggesting the idea of exploiting the high efficiency of fire whirls for oil-spill remediation.

Experimental Methodology for Estimation of Local Heat Fluxes and Burning Rates in Steady Laminar Boundary Layer Diffusion Flames.

Modeling the realistic burning behavior of condensed-phase fuels has remained out of reach, in part because of an inability to resolve the complex interactions occurring at the interface between gas-phase flames and condensed-phase fuels. The current research provides a technique to explore the dynamic relationship between a combustible condensed fuel surface and gas-phase flames in laminar boundary layers. Experiments have previously been conducted in both forced and free convective environments over both solid and liquid fuels.

Role of buoyant flame dynamics in wildfire spread.

Large wildfires of increasing frequency and severity threaten local populations and natural resources and contribute carbon emissions into the earth-climate system. Although wildfires have been researched and modeled for decades, no verifiable physical theory of spread is available to form the basis for the precise predictions needed to manage fires more effectively and reduce their environmental, economic, ecological, and climate impacts. Here, we report new experiments conducted at multiple scales that appear to reveal how wildfire spread derives from the tight coupling between flame dynamics induced by buoyancy and fine-particle response to convection.

2D IR spectra of cyanide in water investigated by molecular dynamics simulations.

Using classical molecular dynamics simulations, the 2D infrared (IR) spectroscopy of CN(-) solvated in D2O is investigated. Depending on the force field parametrizations, most of which are based on multipolar interactions for the CN(-) molecule, the frequency-frequency correlation function and observables computed from it differ. Most notably, models based on multipoles for CN(-) and TIP3P for water yield quantitatively correct results when compared with experiments.

Testing a multistage rating scale for clinical evaluation of all-ceramic surfaces.

Purpose: This study tested the applicability of a multistage rating scale based on modified California Dental Association (CDA) criteria and the original criteria of the CDA for surface evaluation of all-ceramic restorations with the use of dental stone replicas, photographs, and scanning electron microscopy (SEM).

Materials And Methods: Two examiners clinically evaluated 105 all-ceramic restoration units in the posterior region after a mean observation period of 42.2 months; the examiners employed the CDA criteria and a detailed six-stage rating scale.

Surface characteristics of zirconia-based posterior restorations: clinical and scanning electron microscopic analysis.

Aim: The aim of this prospective clinical trial was to evaluate the performance of zirconia-based all-ceramic posterior fixed partial dentures (FPDs) after 4 years of clinical use.

Materials And Methods: Fifteen patients who needed 3- or 4-unit posterior FPDs were enrolled in the study. One manufacturer fabricated all restorations, following established clinical protocols and using computer-aided design/computer-aided manufacturing technology and one veneering material.

Pentacene thin-film transistors encapsulated by a thin alkane layer operated in an aqueous ionic environment.

The encapsulation of pentacene thin-film transistors (TFTs) by a 50 nm thick layer of a long chain alkane (C₄₄H₉₀) enables the operation in an aqueous solution of 1 mM NaCl. It is the first time that pentacene TFTs operate successfully in a liquid environment. This opens new perspectives for biocompatible sensor devices based on pentacene TFTs.

Zirconia posterior fixed partial dentures: a prospective clinical 3-year follow-up.

Purpose: The aim of this prospective clinical trial was to evaluate the reliability of three- and four-unit posterior fixed partial dentures (FPDs) with zirconia frameworks after 3 years of clinical function.

Materials And Methods: Thirty patients, each needing a posterior FPD to restore one or two missing teeth, were included in the study. Preparation guidelines were: occlusal reduction of 1.

Noncontact intraoral measurement of force-related tooth mobility.

The aim of this pilot study was to measure force-related tooth mobility. Vertical and horizontal anterior tooth mobility in 31 healthy periodontal subjects was measured by a noncontact optical measurement technique. The subjects continuously increased the force on each tooth by biting on a load cell.

Use of variable remineralization periods to improve the abrasion resistance of previously eroded enamel.

The objective of the study was to evaluate the period of remineralization needed to re-establish the resistance of eroded enamel against brushing abrasion. Enamel specimens were prepared from 84 polished bovine incisors. The samples were evenly distributed among 7 groups (A-G) and submitted to ten alternating de- and remineralization cycles which included abrasion by toothbrushing.