Is Intermittent Control the Source of the Non-Linear Oscillatory Component (0.2-2Hz) in Human Balance Control?

Objective: To explain the 0.2-2Hz oscillation in human balance.

Motivation: Oscillation (0.

Automated semi-real-time detection of muscle activity with ultrasound imaging.

Ultrasound imaging (USI) biofeedback is a useful therapeutic tool; however, it relies on qualitative assessment by a trained therapist, while existing automatic analysis techniques are computationally demanding. This study aims to present a computationally inexpensive algorithm based on the difference in pixel intensity between USI frames. During an offline experiment, where data was analyzed after the study, participants performed isometric contractions of the gastrocnemius medialis (GM) muscle, as executed (30% of maximum contraction) or attempted (low force contraction up to a point when the participant is aware of exerting force or contracting the muscle) movements, while USI, EMG, and force data were recorded.

MRCP as a biomarker of motor action with varying degree of central and peripheral contribution as defined by ultrasound imaging.

Motor imagination is an alternative rehabilitation strategy for people who cannot execute real movements. However, it is still a matter of debate to which degree it involves activation of deeper muscle structures, which cannot be detected by surface electromyography (SEMG). Sixteen able-bodied participants performed cue based isometric ankle plantar flexion (active movement) followed by active relaxation under four conditions: executed movements with two levels of muscle contraction (fully executed and attempted movements, EM and AM) and motor imagination with and without detectable muscle twitches (IT and I).

Ultrasound Imaging as a Diagnostic Tool to Assess the Functional Status of Muscles after a Spinal Cord Injury.

The aim of this study was to evaluate the use of ultrasound imaging (USI) as a diagnostic tool to assess muscle function after a spinal cord injury (SCI). Ultrasound videos of the gastrocnemius medialis muscle were recorded both at rest and during attempted maximum voluntary contraction (MVC) for fifteen participants with a SCI and fifteen able-bodied controls. Measurements were repeated at monthly intervals for participants in the SCI group during their inpatient stay.

Investigation of different stimulation patterns with doublet pulses to reduce muscle fatigue.

Functional electrical stimulation is a common technique used in the rehabilitation of individuals with a spinal cord injury to produce functional movement of paralysed muscles. However, it is often associated with rapid muscle fatigue which limits its applications. The objective of this study is to investigate the effects on the onset of fatigue of different multi-electrode patterns of stimulation via multiple pairs of electrodes using doublet pulses: Synchronous stimulation is compared to asynchronous stimulation patterns which are activated sequentially (AsynS) or randomly (AsynR), mimicking voluntary muscle activation by targeting different motor units.

Bipedal robotic walking control derived from analysis of human locomotion.

This paper proposes the design of a bipedal robotic controller where the function between the sensory input and motor output is treated as a black box derived from human data. In order to achieve this, we investigated the causal relationship between ground contact information from the feet and leg muscle activity n human walking and calculated filter functions which transform sensory signals to motor actions. A minimal, nonlinear, and robust control system was created and subsequently analysed by applying it to our bipedal robot RunBot III without any central pattern generators or precise trajectory control.

Visuo-manual tracking: does intermittent control with aperiodic sampling explain linear power and non-linear remnant without sensorimotor noise?

Key Points: A human controlling an external system is described most easily and conventionally as linearly and continuously translating sensory input to motor output, with the inevitable output remnant, non-linearly related to the input, attributed to sensorimotor noise. Recent experiments show sustained manual tracking involves repeated refractoriness (insensitivity to sensory information for a certain duration), with the temporary 200-500 ms periods of irresponsiveness to sensory input making the control process intrinsically non-linear. This evidence calls for re-examination of the extent to which random sensorimotor noise is required to explain the non-linear remnant.

Abdominal functional electrical stimulation to improve respiratory function after spinal cord injury: a systematic review and meta-analysis.

This corrects the article DOI: 10.1038/sc.2016.

A functional electrical stimulation system for human walking inspired by reflexive control principles.

This study presents an innovative multichannel functional electrical stimulation gait-assist system which employs a well-established purely reflexive control algorithm, previously tested in a series of bipedal walking robots. In these robots, ground contact information was used to activate motors in the legs, generating a gait cycle similar to that of humans. Rather than developing a sophisticated closed-loop functional electrical stimulation control strategy for stepping, we have instead utilised our simple reflexive model where muscle activation is induced through transfer functions which translate sensory signals, predominantly ground contact information, into motor actions.

Intermittent control of unstable multivariate systems with uncertain system parameters.

Multivariable intermittent control (MIC) combines stability with flexibility in the control of unstable systems. Using an underlying continuous-time optimal control design, MIC uses models of the physical system to generate multivariate open-loop control signals between samples of the observed state. Using accurate model values of physical system parameters, stability of the closed loop system is not dependent upon sample interval.

Abdominal functional electrical stimulation to improve respiratory function after spinal cord injury: a systematic review and meta-analysis.

Objectives: Abdominal functional electrical stimulation (abdominal FES) is the application of a train of electrical pulses to the abdominal muscles, causing them to contract. Abdominal FES has been used as a neuroprosthesis to acutely augment respiratory function and as a rehabilitation tool to achieve a chronic increase in respiratory function after abdominal FES training, primarily focusing on patients with spinal cord injury (SCI). This study aimed to review the evidence surrounding the use of abdominal FES to improve respiratory function in both an acute and chronic manner after SCI.

Intermittent control of unstable multivariate systems.

A sensorimotor architecture inspired from biological, vertebrate control should (i) explain the interface between high dimensional sensory analysis, low dimensional goals and high dimensional motor mechanisms and (ii) provide both stability and flexibility. Our interest concerns whether single-input-single-output intermittent control (SISO_IC) generalized to multivariable intermittent control (MIC) can meet these requirements.We base MIC on the continuous-time observer-predictorstate-feedback architecture.

Abdominal functional electrical stimulation to enhance mechanical insufflation-exsufflation.

Context: Respiratory complications, attributed to the build-up of secretions in the airway, are a leading cause of rehospitalisation for the tetraplegic population. Previously, we observed that the application of Abdominal Functional Electrical Stimulation (AFES) improved cough function and increased demand for secretion removal, suggesting AFES may aid secretion clearance. Clinically, secretion clearance is commonly achieved by using Mechanical insufflation-exsufflation (MI-E) to simulate a cough.

Abdominal Functional Electrical Stimulation to Assist Ventilator Weaning in Acute Tetraplegia: A Cohort Study.

Background: Severe impairment of the major respiratory muscles resulting from tetraplegia reduces respiratory function, causing many people with tetraplegia to require mechanical ventilation during the acute stage of injury. Abdominal Functional Electrical Stimulation (AFES) can improve respiratory function in non-ventilated patients with sub-acute and chronic tetraplegia. The aim of this study was to investigate the clinical feasibility of using an AFES training program to improve respiratory function and assist ventilator weaning in acute tetraplegia.

Detection of the motor points of the abdominal muscles.

Purpose: Abdominal functional electrical stimulation (AFES) is a technique intended to improve respiratory function in tetraplegia where breathing is affected due to abdominal muscle paralysis. Although it is known that optimal muscle contraction is achieved when electrical stimulation is applied close to the muscle motor point, AFES studies have used a variety of electrode positions. This study aims to investigate the feasibility of using Neuromuscular Electrical Stimulation to detect the motor points of the abdominal muscles, and to evaluate the intrasubject repeatability and intersubject uniformity of their positions, to find the most suitable AFES electrode location.

Non-intrusive real-time breathing pattern detection and classification for automatic abdominal functional electrical stimulation.

Abdominal Functional Electrical Stimulation (AFES) has been shown to improve the respiratory function of people with tetraplegia. The effectiveness of AFES can be enhanced by using different stimulation parameters for quiet breathing and coughing. The signal from a spirometer, coupled with a facemask, has previously been used to differentiate between these breath types.

Does the motor system need intermittent control?

Explanation of motor control is dominated by continuous neurophysiological pathways (e.g., transcortical, spinal) and the continuous control paradigm.

Intermittent control models of human standing: similarities and differences.

Two architectures of intermittent control are compared and contrasted in the context of the single inverted pendulum model often used for describing standing in humans. The architectures are similar insofar as they use periods of open-loop control punctuated by switching events when crossing a switching surface to keep the system state trajectories close to trajectories leading to equilibrium. The architectures differ in two significant ways.

Investigation of robotic-assisted tilt-table therapy for early-stage spinal cord injury rehabilitation.

Damage to the spinal cord compromises motor function and sensation below the level of injury, resulting in paralysis and progressive secondary health complications. Inactivity and reduced energy requirements result in reduced cardiopulmonary fitness and an increased risk of coronary heart disease and cardiovascular complications. These risks may be minimized through regular physical activity.

Changes in pulmonary function measures following a passive abdominal functional electrical stimulation training program.

Objective: To demonstrate the effect of a passive abdominal functional electrical stimulation (AFES) training program on unassisted respiratory measures in tetraplegia.

Design: Longitudinal feasibility study.

Setting: National spinal injuries unit in a university teaching hospital.

Interfacing sensory input with motor output: does the control architecture converge to a serial process along a single channel?

Modular organization in control architecture may underlie the versatility of human motor control; but the nature of the interface relating sensory input through task-selection in the space of performance variables to control actions in the space of the elemental variables is currently unknown. Our central question is whether the control architecture converges to a serial process along a single channel? In discrete reaction time experiments, psychologists have firmly associated a serial single channel hypothesis with refractoriness and response selection [psychological refractory period (PRP)]. Recently, we developed a methodology and evidence identifying refractoriness in sustained control of an external single degree-of-freedom system.

Refractoriness in sustained visuo-manual control: is the refractory duration intrinsic or does it depend on external system properties?

Researchers have previously adopted the double stimulus paradigm to study refractoriness in human neuromotor control. Currently, refractoriness, such as the Psychological Refractory Period (PRP) has only been quantified in discrete movement conditions. Whether refractoriness and the associated serial ballistic hypothesis generalises to sustained control tasks has remained open for more than sixty years.

Frequency-domain identification of the human controller.

System identification techniques applied to experimental human-in-the-loop data provide an objective test of three alternative control-theoretical models of the human control system: non-predictive control, predictive control, and intermittent predictive control. A two-stage approach to the identification of a single-input single-output control system is used: first, the closed-loop frequency response is derived using the periodic property of the experimental data, followed by the fitting of a parametric model. While this approach is well-established for non-predictive and predictive control, it is here used for the first time with intermittent predictive control.

Identification of intermittent control in man and machine.

Regulation by negative feedback is fundamental to engineering and biological processes. Biological regulation is usually explained using continuous feedback models from both classical and modern control theory. An alternative control paradigm, intermittent control, has also been suggested as a model for biological control systems, particularly those involving the central nervous system.