[Long-term ecological and genetic consequences of use of dioxin-containing environmental agents].

The long-term consequences of the use of dioxine-containing ecotoxic agents in the USA in 1961-1972 are ecologically and genetically characterized. There were increases in the incidence of pathological reproductive events in the contaminated region. It is concluded that there will be higher probability of abnormalities in the families of individuals born at war or just thereof.

[Ways and means for prolonging the action of drugs (the status of the problem and the outlook)].

The modern approaches and concrete variants of the up-to-date means of prolongation of the biological effects of medicinal compounds having high tropic target-structures in the organism (pharmacodynamic drugs) are summarized. According to the principles of the influence on biodistribution, pharmacodynamics and metabolism of drugs, three main methods of prolongation: (technological (pharmaceutical), chemical and physiological are distinguished. The expediency of distinguishing a new method of prolongation--immunological is grounded.

[Protective action of estrogen-progestin preparations in reproductive function disorder from subtoxic doses of organophosphorus compounds].

The action of subtoxic doses of armine and nibufin administered alone and combined with steroid drugs on the rat reproductive function and uterine tissue RNA content was studied experimentally. The subtoxic doses of the drugs increased sharply the luteinizing hormone releasing factor content in the hypothalamus, as well as the synthesis and excretion of luteinizing and follicle-stimulating hormones and RNA content in the uterine tissue. Estrogen-progestin drugs, particularly infecundin, exerted a protective action in armine- and nibufin-produced abnormalities of the reproductive function.

[Effect of armin on the ultrastructure of the neuromuscular synapse].

Alterations induced by the cholinesterase inhibitor armin (5.10(-7) g/ml) in the ultrastructure of motor nerve endings of the rat phrenic diaphragmal preparations at rest or electric stimulation of the nerve were studied. It was shown that armin at rest induced ultrastructural lesions in the endings similar to those in the control preparations during nerve stimulation.