[Diagnosis of neuroinfections in children].

Presents an overview of domestic and foreign sources on the diagnosis of neuroinfections in children of different etiologies based on epidemiological, physical, cerebrospinal fluid, etiological, radiation and other methods. Their combination makes it possible to establish the syndrome of neuroinfection (meningitis, encephalitis, myelitis, polyradioloneuritis, etc.), the severity, the presence of complications, the nature of the course, etiology.

The Telomeric Repeats of HHV-6A Do Not Determine the Chromosome into Which the Virus Is Integrated.

Human herpes virus 6A (HHV-6A) is able to integrate into the telomeric and subtelomeric regions of human chromosomes representing chromosomally integrated HHV-6A (ciHHV-6A). The integration starts from the right direct repeat (DR) region. It has been shown experimentally that perfect telomeric repeats (pTMR) in the DR region are required for the integration, while the absence of the imperfect telomeric repeats (impTMR) only slightly reduces the frequency of HHV-6 integration cases.

[Immunopatological and genetic aspects of pathogenesis of CNS lesions in VZV infection].

The review article provides information about the features of the Varicella-zoster virus (VZV), about the clinical manifestations of CNS damage in acute and chronic VZV infection in children and adults, about the mechanisms of interaction of the pathogen with the immune system during the development of the disease. The question of whether to consider neurological disorders in VZV infection as a complication or manifestation of the disease caused by a defective virus or the presence of subclinical immunodeficiency is discussed, which is confirmed by modern scientific studies. The critical mechanisms of immune defense against VZV, which are the main reason for the penetration of the virus into the CNS and the development of neurological disorders, as well as the relationship between VZV genotypes, the presence of mutations in the gE gene and the nature of the course, the identification of rare variants of the POLR3A, POLR3C, POLR3E and POLR3F genes associated with violation of IFNs induction, and the development of severe VZV infection, in which vasculopathy also occurs, which is the basis for the use of vascular drugs of complex action, such as Cytoflavin, the effectiveness of which has been proven by the authors.

The vaccine coverage and vaccine immunity status and risk factors of non-protective levels of antibodies against vaccines in children with juvenile idiopathic arthritis: cross-sectional Russian tertiary Centre study.

Background: Immunosuppressive drugs, incomplete vaccine coverage, immune system dysregulation might be factors of a low level of anti-vaccine antibodies in JIA patients. The study aimed to evaluate vaccine coverage, post-vaccine immunity, and risk factors of non-protective levels of antibodies against measles, mumps, rubella, hepatitis B, and diphtheria in JIA patients.

Methods: A cross-sectional study included 170 children diagnosed with JIA aged 2 to 17 years who received routine vaccinations against measles, rubella, mumps (MMR), diphtheria, and hepatitis B national vaccine schedule.

Next generation sequencing analysis of consecutive Russian patients with clinical suspicion of inborn errors of immunity.

Primary immune deficiencies are usually attributed to genetic defects and, therefore, frequently referred to as inborn errors of immunity (IEI). We subjected the genomic DNA of 333 patients with clinical signs of IEI to next generation sequencing (NGS) analysis of 344 immunity-related genes and, in some instances, additional genetic techniques. Genetic causes of the disease were identified in 69/333 (21%) of subjects, including 11/18 (61%) of children with syndrome-associated IEIs, 45/202 (22%) of nonsyndromic patients with Jeffrey Modell Foundation (JMF) warning signs, 9/56 (16%) of subjects with periodic fever, 3/30 (10%) of cases of autoimmune cytopenia, 1/21 (5%) of patients with unusually severe infections and 0/6 (0%) of individuals with isolated elevation of IgE level.

[Economic aspects of occupationally conditioned diseases risk (exemplified by potassium salts extraction enterprises].

Economic evaluation of workers' health disorders risk could include cost equivalent not of health itself, but a prevented risk for worker's health. The authors evaluated a potential underproduced output during disablement period and changes of tax proceeds (except gross domestic product losses). This approach was tested in evaluating risk for.

[THE AVERAGE DURATION OF TREATMENT OF THE INJURED WITH DIFFERENT FORMS OF ACUTE INTOXICATIONS OF CHEMICAL ETIOLOGY].

The article presents materials relate to analysis of average duration of the injured of Omsk under different forms of acute chemical intoxications during 2001-2013. It was established that during analyzed period as a result of implementation of new organizational technologies occurred reliable. decreasing of duration of treatment of patients with light, medium and severe forms of acute chemical intoxications.

[THE MEDICAL SOCIAL STUDY OF QUALITY OF NURSING CARE].

The article considers medical social aspects of quality of nursing care. The questionnaire survey of nursing personnel of oblast and municipal medical organizations of Omsk was carried out. The results permitted evaluating qualification of nursing medical personnel, organization of personnel training at workplace and internal control of knowledge and skills in medical organizations.

[The hospitalized morbidity of children population of Omsk as a result of acute intoxication of chemical etiology in 2003-2012].

The article analyzes the rate of hospitalization of children with acute intoxications of chemical etiology in Omsk during 2003-2012. It is established that during the mentioned period decrease of hospitalized morbidity of acute intoxication of chemical etiology occurred among children population of Omsk. The basis of hospitalization constitute acute medicinal intoxication.

[The actual incidence of the population in the RF subject: assessment of economic effect (losses)].

In the paper there is presented an analysis and evaluation of the economic losses associated with the actual incidence of the population of the Altai Region on disease classes "Poisoning by drugs, medicaments and biological substances" (T36-T50) and "Toxic effect of substances, mainly non-medical purpose" (T51-T65), including the assessment of the underproduced product in economy of the region in monetary terms, assessment changes in cash flows on the budgets of the Russian Federation (tax receipts). The time period of analysis on disease classes is 5 years (2007-2011).

[The analysis of infant mortality in Omsk oblast' in 2002-2012].

In Omsk oblast during 2002-2012 a stable increase of birth rate is noted. Against the background of birth rate increase up to 2011 a positive dynamics of decrease of infant mortality was noted. In 2012, indicator of infant mortality increased up to 38.

[The dynamics of population mortality due to acute alcoholic intoxications in the Russian Federation].

The article deals with the study of dynamics of population mortality in the Russian Federation as a result of acute intoxications in 2001-2010. In the Russian Federation, during the examined period, population mortality due to casual acute alcoholic intoxications decreased up to 2.1 times.

[The dynamics of the indicators of population mortality in Omskaya oblast as a result of acute chemical intoxications in 2001-2010].

The study was organized to investigate the dynamics of indicators of population mortality in Omskaya oblast due to acute chemical intoxications in 2001-2010. The dynamics of indicators of population mortality under acute exogenous intoxications is a chief medical demographic characteristic of premature social losses. The analysis of the mortality indicators structure favors to reveal the major causes of development of unfavorable situations and to develop the concept of organization of chemical security of population in Omskaya oblast.

[The morbidity of persons dwelling in the gerontological centers].

The article deals with the results of comprehensive medical social study of medical social characteristics of morbidity and disability among persons dwelling in the gerontological centers. It is established that persons dwelling permanently in the gerontological centers need a special attention of the medical stuff and highly require the long-term supportive care and rehabilitation and social support measures.

[Medico-social studies of reproductive behaviour in first-term female students of vocational schools].

This questionnaire study was designed to analyse reproductive behaviour of 702 first-term female students of vocational schools located in the city of Omsk. It provided data on the sources and level of awareness of sex life hygiene. Recommendations are proposed for the development of prophylactic measures.

[The medical social aspects of acute intoxications of chemical etiology].

The purpose of the study was to investigate the medical social aspects of morbidity of adult population in case of such forms of traumatism as acute chemical intoxications. The comprehensive medical social study of the issues of chemical pathology was executed applying the factorial analysis technique. This particular method of statistical analysis gave an opportunity to establish the major causes and risk factors of development of acute intoxications of chemical etiology in adult population of large industrial center.

[On the results of the medical social study of the female infertility].

The results of the medical social study of the female infertility in the Omskaya Oblast from 1995 to 2005 is presented. According the data of the family planning and reproduction center, the portion of the females being observed on the occasion of the infertility, consists 28.6% of general number being registered on the books.

[The state of health of the inmates of children's homes].

The basic results of the study of the general disease incidence and the pathological affectedness of the inmates of children's homes of Omsk oblast during 2000-2005. The respiratory diseases, the diseases of digestive system, the ophthalmic and accessory apparatus diseases, the infectious and parasitogenic diseases, the diseases of nervous system predominate in the structure of morbidity of the children-orphans. According the medical examination data, the percent of the healthy children does not exceed 9% and the percent of the children with chronic diseases makes up to more than 40%.

[Development of chronic diseases in adolescents].

Complex impact of various factors on development of chronic diseases among adolescents aged of 15-17 years and dwelling in districts of Omskaya oblast is analyzed. It is noted that out of twelve factors four of them are of educational pedagogic category. Besides, one of these (the twelfth) takes second rank place emphasizing that making necessary hygienic conditions of education is of highly significance for maintenance of adolescent health.

[A virological description of serous meningitis in children immunized with vaccine against epidemic parotitis].

The morbidity structure was analyzed in children vaccinated against epidemic parotitis in 1993-2002. Eight children (4 with serous meningitis and 4 with lesions of the salivary glands) underwent virologic and immunologic examinations. The molecular typing of the SH-gene fragment of the parotitis virus showed the process in 7 cases to be provoked by the vaccination strain.

[Health of rural population under active migratory processes].

Human health changes occurring in the presence of active migratory processes were analyzed in a rural area of the Orenburg region in 1995 to 2000. There were increases in morbidity and mortality rates. The rates of deaths caused by accidents, injuries and intoxication were noted to rise in the structure of mortality in the able-bodied population.

[Four levels (types) of immune reponse in children with viral parotitis infections].

Four levels (types) of immune response, differing by expression of cytokines (TNF-alpha, IL-1 beta, IL-4, and gamma-IFN) and immunoglobulins IgG2, IgG3, IgG4, and IgE) and by expression and time course of specific cell-mediated and humoral immune response, were detected in children with different clinical forms of mumps. Types 1 and 3 immune response are predominantly cell-mediated, while types 2 and 4 predominantly humoral during the acute phase of the disease. The cytokine and antigen-specific profiles of each type of immune response correlate with the severity of clinical course of mumps.

[Disability in chronic nonspecific diseases of the lungs].

The author presents the data of medical social study of disability caused by chronic nonspecific diseases of the lungs (CNDL) in Omsk and the Omsk region and analyzes the level, structure, and time course of primary disability in relation to sex, age, place of residence, and disability group. Working loss caused by CNDL in cities and in the country is evaluated. Factors promoting the formation of disability in CNDL are evaluated.