Metabolism of pheneturide in the rat and in man.

The biotransformation of pheneturide was studied in humans and in the rat. Human volunteers received a single oral dose of 10 mg/kg of pheneturide and the rats were given repeated doses of 250 mg/kg. Urine from both study groups was extracted with Amberlite XAD-2 and the extracts were separated by preparative HPLC after enzymatic hydrolysis.

Febarbamate: metabolism in man.

The biotransformation of 1-(3-butoxy-2-carbamoyloxypropyl)-5-ethyl-5-phenyl-(1H,3H,5H)-pyrimidine-2,4,6-trione (febarbamate) has been investigated in man. Human volunteers received a single oral dose of 15 mg/kg febarbamate. Twenty two metabolites found in urine were separated and purified by means of an extraction with Amberlite XAD-2 and the high performance liquid chromatography.

Febarbamate: metabolism in the rat.

The metabolism of 1-(3-butoxy-2-carbamoyloxypropyl)-5-ethyl-5-phenyl-(1H,3H,5H)-pyrimidine-2,4,6- trione (febarbamate) in the rat has been studied after oral administration. Using high performance liquid chromatography, fifteen metabolites were isolated from urine, purified and identified by MS and NMR spectrometry. Febarbamate was extensively metabolized and only traces of the unchanged compound were found.

Comparative study of two anti-ulcerogenic drugs--glaziovine and sulpiride.

The anti-ulcer effect of glaziovine, a major psychotropic alkaloid isolated from Ocotea glaziovii (Laureaceae) and belonging to a new chemical class, has been studied in different types of experimentally induced ulcers in the guinea-pig and the rat. The effect of glaziovine was compared with that of sulpiride.