Publications by authors named "Golan J"

Article Synopsis
  • Degenerative cervical myelopathy (DCM) is a major cause of spinal cord dysfunction in adults, leading to significant health issues and financial costs, with most patients requiring surgery eventually.
  • The review examines various pharmacological agents that might help treat mild DCM or improve surgical results, highlighting mixed evidence for effectiveness in both human and animal studies.
  • Key findings indicate that while some drugs like Riluzole and Cerebrolysin show potential in animal studies, their benefits in humans are inconclusive, and more robust clinical data is needed to explore new neuroprotective therapies for DCM.
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Physical function is the physical ability to fulfill one's daily roles and responsibilities. Poor physical function is detrimental to health and income-generating activities. Unfortunately, there is a lack of validated methods to measure physical function in adult women in low- and middle-income countries, including Ethiopia, the locus of this study.

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Background: Current guidelines for management of anorectal abscesses make no recommendations for operative vs bedside incision and drainage (I&D). The purpose of this study was to determine if management in the operating room is necessary to adequately drain anorectal abscesses and prevent short-term complications for patients presenting to the emergency department (ED).

Methods: Patients with perirectal abscesses were identified and divided into two groups based on intervention type: "bedside" or "operative.

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Global change is reshaping Earth's biodiversity, but the changing distributions of nonpathogenic fungi remain largely undocumented, as do mechanisms enabling invasions. The ectomycorrhizal Amanita phalloides is native to Europe and invasive in North America. Using population genetics and genomics, we sought to describe the life history traits of this successfully invading symbiotic fungus.

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Article Synopsis
  • Canonical sexual reproduction in basidiomycete fungi usually involves the fusion of two haploid individuals, resulting in a genetically diverse mycelial body, but some mushrooms, like Amanita phalloides, can reproduce without mating.
  • Population genomics reveal that both homokaryotic (single nucleus) and heterokaryotic (multiple nuclei) mushrooms coexist in California, indicating that the nuclei of homokaryotic mushrooms can contribute to outcrossing.
  • The study shows that death cap mushrooms have a unique mating type control and can reproduce both alone and with others, enabling their rapid spread in new environments over the past 17 to 30 years.
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Anemia remains a major public health problem, especially in low- and middle-income countries. The World Health Organization recommends several interventions to prevent and manage anemia in vulnerable population groups, including young children, menstruating adolescent girls and women, and pregnant and postpartum women. Daily iron supplementation reduces the risk of anemia in infants, children, and pregnant women, and intermittent iron supplementation reduces anemia risk in menstruating girls and women.

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Background: Physical activity affects nutritional status and health. Currently, there are few validated survey tools for estimating physical activity in rural areas of low-income countries, including Ethiopia, which limits the ability of researchers to assess how physical activity affects nutritional status.

Objectives: This study used accelerometry to validate 2 in-person questionnaires, the global physical activity questionnaire (GPAQ) and the 24-h perceived exertion recall survey (PERS).

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The first genome sequenced of a eukaryotic organism was for , as reported in 1996, but it was more than 10 years before any of the zygomycete fungi, which are the early-diverging terrestrial fungi currently placed in the phyla and , were sequenced. The genome for was completed in 2008; currently, more than 1000 zygomycete genomes have been sequenced. Genomic data from these early-diverging terrestrial fungi revealed deep phylogenetic separation of the two major clades-primarily plant-associated saprotrophic and mycorrhizal versus the primarily mycoparasitic or animal-associated parasites and commensals in the .

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Article Synopsis
  • Understanding the impact of symbiotic relationships on the ecology and evolution of fungal spores has been overlooked in research, even though these interactions are common in various ecosystems.
  • A comprehensive database of spore morphology, encompassing over 26,000 species, revealed significant variations in spore size linked to changes in symbiotic relationships.
  • This study shows that symbiotic status plays a more crucial role than climate in determining spore size distribution among plant-associated fungi, affecting their dispersal abilities compared to free-living fungi.
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Anemia is a major global public health concern with a complex etiology. The main determinants are nutritional factors, infection and inflammation, inherited blood disorders, and women's reproductive biology, but the relative role of each varies between settings. Effective anemia programming, therefore, requires evidence-based, data-driven, contextualized multisectoral strategies, with coordinated implementation.

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Purpose: Full-endoscopic techniques are minimally invasive surgery alternatives to traditional spinal surgery. We performed a systematic review of the literature to assess the costs of these techniques compared to traditional approaches.

Methods: A systematic review of the literature was performed for economic evaluations that compare endoscopic decompressions of the lumbar spine for stenosis or disc herniation to open or microsurgical decompressions.

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Article Synopsis
  • Canonical sexual reproduction in basidiomycete fungi typically requires two different haploid individuals to create a heterokaryotic mycelial body, but recent findings show that some invasive mushrooms can reproduce sexually from a single individual, forming homokaryotic mycelia.
  • In California, genotypes of these homokaryotic mushrooms coexist with heterokaryotic ones, suggesting that homokaryotic mycelia can contribute to outcrossing among different genotypes.
  • The study reveals that the mating process in death cap mushrooms is governed by a single locus, allowing for both unisexual and bisexual reproduction, which may explain the mushroom's rapid invasion and persistence in new areas for up to 30
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  • Lipo-chitooligosaccharides (LCOs) are signaling molecules that influence the relationship between plants and beneficial fungi, but new research shows they also affect non-symbiotic fungi like the human pathogen Aspergillus fumigatus.
  • When A. fumigatus was exposed to different types of LCOs, significant changes occurred in its metabolic profile, impacting the production of compounds that interact with bacteria.
  • The study highlights the potential ecological role of LCOs in competitive interactions between fungi and bacteria, and suggests they can activate silent gene clusters in fungi to produce new metabolites with biological significance.
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Fair and equitable benefit sharing of genetic resources is an expectation of the Nagoya Protocol. Although the Nagoya Protocol does not yet formally apply to Digital Sequence Information ("DSI"), discussions are currently underway regarding to include such data through ongoing Convention on Biological Diversity ("CBD") negotiations. While Indigenous Peoples and Local Communities ("IPLC") expect the value generated from genomic data to be subject to benefit sharing arrangements, a range of views are currently being expressed by Nation States, IPLC and other stakeholders.

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Today, plastic surgery is a well-known profession with highly respected surgeons from institutions all over the world. Over the last several decades numerous clinical and technological advances have been made, thanks to the dedication and hard work of these outstanding professionals; however, things were not always this way. At the turn of the 20 century, Israel had yet to be introduced to the field of plastic surgery.

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Populations of the entomopathogenic fungus Batkoa major were analyzed using sequences of four genomic regions and evaluated in relation to their genetic diversity, insect hosts and collection site. This entomophthoralean pathogen killed numerous insect species from 23 families and five orders in two remote locations during 2019. The host list of this biotrophic pathogen contains flies, true bugs, butterflies and moths, beetles, and barkflies.

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Background: Nucleus replacement devices are designed to replace the native pain-generating lumbar nucleus while preserving the annulus fibrosus, endplates, and natural motion. The DASCOR Disc Arthroplasty Device seemed to perform well clinically but was discontinued in 2009. While there are no commercially available NRDs today, the potential advantages of using such devices have prompted a renewed interest in further developing the technology and assessing long-term outcomes for the DASCOR device.

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Prenatal micronutrient supplements are cost-effective in reducing nutritional deficiencies and adverse pregnancy and birth outcomes. However, poor adherence remains a potential barrier to the successful implementation of these supplementation programs. This systematic review assessed the effectiveness of interventions designed to increase adherence to prenatal micronutrient supplementation.

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Article Synopsis
  • The study investigates the link between vertebral anatomy and the likelihood of complications from pedicle screw placement during spine surgery, focusing on the width of the vertebral isthmus.
  • Analysis of CT scans from patients revealed a significant inverse correlation between isthmus width and pedicle screw breach incidence, with major breaches occurring more frequently in thoracic levels compared to lumbar levels.
  • Although many breaches were detected, especially in areas with the thinnest isthmus, few led to clinical issues, suggesting that not all breaches are problematic if the screws are secure and patients are asymptomatic.
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Fungi disperse spores to move across landscapes and spore liberation takes different patterns. Many species release spores intermittently; others release spores at specific times of day. Despite intriguing evidence of periodicity, why (and if) the timing of spore release would matter to a fungus remains an open question.

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Micronutrient supplementation during pregnancy has been shown to be a cost-effective method to reduce the risk of adverse pregnancy and birth outcomes. However, one of the main barriers to the successful implementation of a micronutrient supplementation program in pregnancy is poor adherence. Our review will assess the effectiveness of interventions designed to increase adherence to micronutrient supplements in pregnancy.

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Hypothenar hammer syndrome affects less than 1% of the population, but if the diagnosis is delayed, digital gangrene and critical ischemia can ensue. The condition is caused by injury to the ulnar artery at the level of the hook of hamate when the palm of the hand is repetitively used as a hammer. Injury includes segmental occlusion of the ulnar artery and aneurysmal formation with or without occlusion.

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, the causal agent of soybean rust (SBR), is a global threat to soybean production. Since the discovery of SBR in the continental United States, quantitative polymerase chain reaction assays based on the internal transcribed spacer (ITS) ribosomal DNA locus were established for its rapid detection. However, insufficient data were initially available to test assays against factors that could give rise to misidentification.

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