Six Decades of History of Hypertension Research at the University of Toledo: Highlighting Pioneering Contributions in Biochemistry, Genetics, and Host-Microbiota Interactions.

Purpose Of Review: The study aims to capture the history and lineage of hypertension researchers from the University of Toledo in Ohio and showcase their collective scientific contributions dating from their initial discoveries of the physiology of adrenal and renal systems and genetics regulating blood pressure (BP) to its more contemporary contributions including microbiota and metabolomic links to BP regulation.

Recent Findings: The University of Toledo College of Medicine and Life Sciences (UTCOMLS), previously known as the Medical College of Ohio, has contributed significantly to our understanding of the etiology of hypertension. Two of the scientists, Patrick Mulrow and John Rapp from UTCOMLS, have been recognized with the highest honor, the Excellence in Hypertension award from the American Heart Association for their pioneering work on the physiology and genetics of hypertension, respectively.

Impact of Nutritional Epigenetics in Essential Hypertension: Targeting microRNAs in the Gut-Liver Axis.

Purpose Of Review: To review the current knowledge on interactions between dietary factors and microRNAs (miRNAs) in essential hypertension (EH) pathogenesis.

Recent Findings: There exists an integration of maintenance signals generated by genetic, epigenetic, immune, and environmental (e.g.

Effect of cobalt-60 gamma radiation on reproductive disturbance in freshwater prawn (De Man, 1879).

The present study was designed to evaluate the effect of acute level of Co gamma radiation on fecundity of freshwater prawn . Prawns were exposed to four different dose levels (3, 30, 300 and 3000 mGy) and their reproductive disturbances i.e Gonadosomatic Index (GSI), Egg Clutch somatic Index (ESI), Egg Counts and Egg hatching rates were calculated.

Impact of chlorpyrifos on behavior and histopathological indices in different tissues of freshwater fish Channa punctatus (Bloch).

The present systematic experiment was conducted to estimate the impact of behavioral and pathological indices on freshwater fish Channa punctatus exposed to sub-lethal concentration (5 ppm) of an organophosphorus insecticide chlorpyrifos (CPF). Fish were segregated into four experimental groups (G1, control; G2, 10 days; G3, 20 days; and G4, 30 days exposure), each group comprises 15 fish in triplicate. The behavioral and histological changes were assessed in each group.

Effect of cobalt-60 gamma radiation on total hemocyte content and biochemical parameters in (De Man, 1879).

The effect of low level cobalt-60 (Co) gamma radiation on the freshwater prawn was evaluated by observing their hemocyte counts and biochemical parameters. Prawns were exposed to 3, 30, 300 and 3000 milligray (mGy) dose levels and their tissues of gills, hepatopancreas and muscle were analyzed. The results showed that the number of hemocytes in the hemolymph and concentrations of protein and carbohydrate were significantly reduced in irradiated groups than compared to the control prawn.