1,25-Dihydroxyvitamin D stimulates odontoblastic differentiation of human dental pulp-stem cells in vitro.

Background: 1,25-Dihydroxyvitamin D (1,25-OH D) plays an important role in mineralized tissue metabolism, including teeth. However, few studies have addressed its role in odontoblastic differentiation of human dental pulp-stem cells (hDPSCs).

Aim: This study aimed to understand the influence of various concentrations of 1,25-OH D on the proliferation capacity and early dentinogenesis responses of hDPSCs.