Publications by authors named "Gokila Palanisamy"

Background: Soil-transmitted helminths (STH) affect approximately 1.5 billion people globally. The current STH control strategy is annual or twice-annual preventive chemotherapy, typically school-based deworming targeting children and women of reproductive age.

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DeWorm3 is an ongoing multi-country community-based cluster-randomized trial assessing the feasibility of interrupting transmission of soil-transmitted helminths (STH) with community-wide mass drug administration (cMDA). In Tamil Nadu, India, community drug distributors (CDDs) worked with DeWorm3 field staff to counsel community members and deliver door-to-door deworming treatment. As CDDs were likely to influence successful delivery of cMDA, we describe drivers of CDDs' knowledge, attitudes, and motivation toward delivery of cMDA.

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The high burden of soil-transmitted helminth infections has been studied in India; however, little data exist on zoonotic helminths, and on animal-associated exposure to soil-transmitted helminths. Our study took place in the Jawadhu Hills, which is a tribal region in Tamil Nadu, India. Using a One Health approach, we included animal and environmental samples and human risk factors to answer questions about the associations among infected household soil, domestic animals, and human risk factors.

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Article Synopsis
  • India has been leading the largest school-based deworming initiative since 2015, targeting approximately 250 million children to combat soil-transmitted helminths (STH) in a bid to reduce morbidity, though reinfection rates remain high in certain areas.
  • A community survey in Tamil Nadu, part of the DeWorm3 Project, involved comprehensive data collection from over 140,000 individuals across 36,536 households to assess STH prevalence over five years, with 6089 participants providing stool samples for analysis.
  • Results revealed a 17% unweighted prevalence of STH, predominantly hookworm, with age-related factors influencing infection rates, while Ascaris lumbricoides and Trichuris trichiura showed
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