Comparison of Conventional Technique with Suture Fixation and Subperiosteal Tight Pocket Technique on Revision Cochlear Implantation Rate.

Several fixation methods have been described to secure the cochlear implant's receiver/stimulator, but the optimal stabilization technique is still being debated. The aim of this study was to compare the conventional technique with suture fixation to the subperiosteal tight pocket technique in terms of revision cochlear implantation rate. A retrospective review was conducted on the medical records of 649 patients who underwent cochlear implantation.

Audiological Results of Total Ossicular Replacement Prosthesis with Cartilage Shoe Technique.

Objective: The aim of this study was to investigate functional results of total ossicular replacement prosthesis (TORP) shaft stabilization with a cartilage shoe in chronic otitis media patients with cholesteatoma who had undergone canal wall down tympanomastoidectomy (CWDT). In addition, it was determined whether the presence of granular and edematous mucosa in middle ear altered functional outcomes.

Methods: Sixty patients, who had undergone CWDT with the use of TORP for the reconstruction of ossicular chain, were divided into two groups.

[Extranasal glioma surgery in a newborn: a case report].

Nasal gliomas are rarely seen, congenital, benign and nonhereditary lesions. These are not true tumors that occur due to extradural malposition of ectopic glial tissue during embryologic development. These are generally diagnosed during childbirth and may have an intracranial extension with fibrous stalk.

Comparative Fixation and Subsidence Profiles of Cementless Unicompartmental Knee Arthroplasty Implants.

Background: Aseptic loosening is the primary cause of failure for both cemented and cementless unicondylar knee replacements (UKRs). Micromotion and subsidence of tibial baseplate are two causes of failure, due to poor fixation and misalignment, respectively.

Methods: Stair ascent activity profiles from Bergmann et al and Li et al were used.

The Regulation of Matrix Metalloproteinase Expression and the Role of Discoidin Domain Receptor 1/2 Signalling in Zoledronate-treated PC3 Cells.

Discoidin Domain Receptors (DDR1/DDR2) are tyrosine kinase receptors which are activated by collagen. DDR signalling regulates cell migration, proliferation, apoptosis and matrix metalloproteinase (MMP) production. MMPs degrade extracellular matrix (ECM) and play essential role in tumor growth, invasion and metastasis.

Atrophic rhinitis caused by Cedecea davisae with accompanying mucocele.

Atrophic rhinitis is a chronic inflammatory disease characterized by progressive atrophy of nasal mucosa. Cedecea davisae, a rare pathogen, is a new member of Enterobacteriaceae family. In this article, we report a patient with atrophic rhinitis whose culture test revealed Cedecea davisae.

Biochemical markers of glucose metabolism may be used to estimate the degree and progression of iron overload in the liver and pancreas of patients with β-thalassemia major.

The use of cardiac and hepatic T2* MRI measurements to predict the amount of iron accumulation in these organs has been studied extensively and was suggested to be used reliably. However, it may not be practical to screen other organs with MRI related to economical issues and also the prolonged imaging durations. Herein, we aimed to test the use of fasting glucose, fasting, and postprandial insulin, homeostasis model assessment-insulin resistance (HOMA-IR) (calculated as insulin (μIU/ml) × glucose (mg/dl)/22.

Analysis of tumor necrosis factor α-induced and nuclear factor κB-silenced LNCaP prostate cancer cells by RT-qPCR.

Prostate cancer is the second leading cause of morbidity and mortality in males in the Western world. In the present study, LNCaP, which is an androgen receptor-positive and androgen-responsive prostate cancer cell line derived from lymph node metastasis, and DU145, which is an androgen receptor-negative prostate cancer cell line derived from brain metastasis, were investigated. TNFα treatment decreased p105 and p50 expression and R1881 treatment slightly decreased p105 expression but increased p50 expression with or without TNFα induction.

[Peripheral ossifying fibroma of maxilla].

Peripheral ossifying fibromas are rare pathologies characterized by the replacement of bone to fibrous tissue. In this article, we report a 64-year-old female case admitted to our clinic with a mass in the oral cavity for 10 years. On physical examination, a 5x4 cm, well-defined, pedunculated mass was detected in the anterior arch of the right maxilla.

Number of erythrocyte transfusions is more predictive than serum ferritin in estimation of cardiac iron loading in pediatric patients with acute lymphoblastic leukemia.

Background: Transfusions with packed erythrocytes is a common practice in pediatric patients with acute lymphoblastic leukemia (ALL) who are on chemotherapy. Since there is no physiological excretion mechanism for iron, the iron related to erythrocyte transfusions accumulates and may contribute to late cardiac, hepatic and endocrine complications in these patients.

Procedure: In order to evaluate the iron burden among pediatric patients with ALL and define the risk factors associated with higher iron loading, we evaluated 79 pediatric patients with ALL (36 were off-therapy).

Introducing basic molecular biology to Turkish rural and urban primary school children via hands-on PCR and gel electrophoresis activities.

This study includes the results of a 2-day education project titled "Molecular Biology Laboratory Summer School, MoBiLYO." The project was held at a University Research Center by scientists from Department of Pharmacology and graduate students. The project was composed of introductory lectures, model construction, DNA isolation, polymerase chain reaction (PCR), and gel electrophoresis.

Comparison of robot surgery modular and total knee arthroplasty kinematics.

The kinematics of seven knee specimens were measured from 0 to 120 degrees flexion using an up-and-down crouching machine. Motion was characterized by the positions of the centers of the lateral and medial femoral condyles in the anterior-posterior direction relative to a fixed tibia. A modular unicompartmental knee, trochlea flange, and patella resurfacing (multicompartmental knee [MCK] system) were implanted using a surgeon-interactive robot system that provided accurate surface matching.

Stability of the posteromedial fragment in a tibial plateau fracture.

The posteromedial fragment in tibial plateau fractures is considered unstable and requires specific fixation. However, if not loaded by the femur, it may remain stable and not require additional fixation. Our purpose was to determine the size of the posteromedial fragment that would remain unloaded by the femoral-tibial contact area, as a function of fracture line orientation and knee flexion angle.

Preclinical evaluation method for total knees designed to restore normal knee mechanics.

The objective was to develop a simple, rapid, and low-cost method for evaluating proposed new total knee arthroplasty (TKA) models and then to evaluate 3 different TKA models with different kinematic characteristics. A "desktop" knee testing rig was used to apply forces and moments over a full flexion range, representing a spectrum of positions and activities; and the positions of the femur on the tibia were measured. The average neutral path of motion (for compressive force only) and the laxities about the neutral path (for superimposed shear and torque) were determined from 8 knee specimens to be used as a benchmark for the TKA evaluations.

Differential strain of the axially loaded scapholunate interosseus ligament.

Purpose: To directly measure strain changes in the scapholunate ligament via magnetic resonance imaging (MRI) when axially loading the wrist in the neutral and extended positions.

Methods: Six asymptomatic male volunteers without known history of previous wrist injury were enrolled in this MRI-based study. Each subject underwent 3 MRI scans in a 3T scanner: in resting neutral position, in neutral with axial load applied, and in extension with axial load applied.

Total knees designed for normal kinematics evaluated in an up-and-down crouching machine.

We constructed a crouching machine to study the motion of the knee joint, in which a motor was used to wind the quadriceps tendon so as to move the knee from high flexion to extension and back into flexion, while springs simulated hamstrings forces. Seven human cadaveric knees were tested intact and then after anterior cruciate ligament (ACL) resection. Motions of the femur, tibia, and patella were recorded by an optical tracking system.

Design features of total knees for achieving normal knee motion characteristics.

The goal of the study was to achieve a normal neutral anatomical path of motion with a total knee arthroplasty (TKA) using specific motion-guiding design features. Two reference TKA models were used, consisting of a partially conforming double-dished geometry and the same with a central cam-post for femoral rollback. Four experimental TKA models included features to produce femoral rollback with and without guidance for tibial rotation, and a feature to prevent paradoxical anterior femoral sliding.

Factors affecting the impingement angle of fixed- and mobile-bearing total knee replacements: a laboratory study.

Maximum flexion-or impingement angle-is defined as the angle of flexion when the posterior femoral cortex impacts the posterior edge of the tibial insert. We examined the effects of femoral component placement on the femur, the slope angle of the tibial component, the location of the femoral-tibial contact point, and the amount of internal or external rotation. Posterior and proximal femoral placement, a more posterior femoral-tibial contact point, and a more tibial slope all increased maximum flexion, whereas rotation reduced it.

The contact locations in the knee during high flexion.

The aim was to determine the contact locations in the knee in a simulation of a deep squatting position, for both neutral and after tibial rotation. A rig was constructed to load the knee under quadriceps action at flexion angles from 135 to 155 degrees flexion, with a mechanism for rotating the tibia internally or externally. Fiducial points on each bone were digitized in each position of the knee.

Effect of tibial positioning on the diagnosis of posterolateral rotatory instability in the posterior cruciate ligament-deficient knee.

Objective: To determine whether positioning of the tibia affects the degree of tibial external rotation seen during a dial test in the posterior cruciate ligament (PCL)-posterolateral corner (PLC)-deficient knee.

Design: Laboratory investigation.

Setting: Biomechanics laboratory.

Relative positions of the contacts on the cartilage surfaces of the knee joint.

The goal of this project was to determine the centers of contacts (points of closest approach of the articular surfaces) for the tibio-femoral and patello-femoral joints throughout the flexion range, with a focus on high flexion where there is potential overlap between the contacts. The purpose was to determine the implications to the design of joint replacements and tissue engineered implants. Eight cadaveric knees were mounted in a rig with different loading combinations applied to the femur, including axial load, anterior/posterior shear, and internal/external torque.