The effectiveness of different neuroprotective agents in facial nerve injury: An experimental study.

Objectives/hypothesis: To examine and compare the neuroprotective effects of dexamethasone, oxytocin, and resveratrol administration on regeneration after facial nerve crush injury in a rat model.

Study Design: Prospective, randomized, controlled animal study.

Methods: A crush-type facial nerve injury was performed on the right side of all rats (injury group [IG]), whereas there was no injury on the left side (sham group [SG]).

Jak-Stat signaling pathway may play a role in the pathogenesis of cholesteatoma.

Purpose: Jak-Stat signaling pathway is one of the major signal transduction cascades which regulates most of the cellular events such as cell proliferation, differentiation, cell migration and apoptosis. This study aims to determine the activity of Jak-Stat signaling pathway in the pathogenesis of cholesteatoma.

Materials And Methods: Cholesteatoma and skin samples were obtained from 10 patients who underwent tympanomastoidectomy for chronic otitis media with cholesteatoma.