Publications by authors named "Gohar Zeitlian"
Objective: We have previously characterized the reproductive hormone profile in infertile women with diminished ovarian reserve (DOR) as being distinct from that seen in age-comparable healthy controls. Hypothesizing that DOR reflects accelerated reproductive aging, we herein compare urinary reproductive hormone dynamics between young women with DOR and a population of chronologically older perimenopausal controls.
Methods: In this prospective observational study, urinary levels of pituitary gonadotropins (follicle-stimulating hormone and luteinizing hormone) and metabolites of estrogen (estrone conjugate) and progesterone were assessed in daily morning urine samples collected in a spontaneous menstrual cycle in 8 infertile premenopausal women with DOR and in 11 perimenopausal controls.
Objective: To determine whether 25OH-D levels in the follicular fluid (FF) of infertile women undergoing IVF demonstrate a relationship with IVF cycle parameters and outcome, hypothesizing that levels of 25OH-D in body fluids are reflective of vitamin repletion status.
Design: Prospective cohort study.
Setting: Academic tertiary care center.
Objective: To elucidate the reproductive hormone profiles in association with a diagnosis of diminished ovarian reserve (DOR).
Design: Prospective observational study.
Setting: Academic tertiary care infertility practice.
Objective: To determine whether obesity-related reproductive endocrine abnormalities in ovulatory women are reversible with weight loss.
Design: Observational cohort study.
Setting: Healthy volunteers in an academic research environment.
Objectives: To investigate whether a diagnosis of diminished ovarian reserve (DOR) in premenopausal years has adverse implications for skeletal health and quality of life.
Design: This was a cross-sectional study of infertile, albeit healthy, mid-reproductive-age women (younger than 42 y) attending an academic infertility practice.
Results: Eighty-nine women with varying causes of infertility were prospectively enrolled.
Objective: To evaluate if the levels of the central regulators of osteoclast activity, osteoprotegerin (OPG) and receptor activator for nuclear factor kappaB-ligand (RANk-L), correlate with bone mineral density (BMD) parameters in premenopausal infertile women.
Design: Cross-sectional study.
Setting: Academic infertility practice.
Onset of ovulation after menarche in girls: a longitudinal study.
J Clin Endocrinol Metab
April 2008
Introduction: Hypothalamic-pituitary axis maturity has been believed to be the rate-limiting step in the development of ovulatory menstrual cycles. We hypothesized that, given current nutritional conditions, hypothalamic-pituitary axis maturation would be relatively rapid in menarcheal girls.
Methods: Daily urine and menstrual records were collected for 2 yr each from 10 girls aged 11-13 yr at study entry.
Objective: To identify the prevalence of vasomotor symptoms (VMS) in a population of premenopausal infertile women and to determine whether VMS is associated with enhanced bone turnover and low bone mineral density (BMD).
Design: Cross-sectional study.
Setting: Academic infertility practice.
Context: Female obesity is linked to abnormal menstrual cycles, infertility, reproductive wastage, and deficient LH, FSH, and progesterone secretion.
Objective And Design: To elucidate the reproductive defects associated with obesity, we sampled 18 eumenorrheic (nonpolycystic ovary syndrome) women with a mean +/- sem body mass index of 48.6 +/- 1.
Objective: To determine whether reproductive hormone levels are affected by human immunodeficiency virus (HIV) and drug use.
Design: HIV-infected and uninfected women (N=429), median age 45, were interviewed on menstrual frequency, demographic and psychosocial characteristics, and drug use behaviors. Serum was obtained on cycle days 1 to 5 in women reporting regular menses.