Publications by authors named "Goh T"

Background: Recently, the phase angle (PhA) has emerged as an essential indicator of cellular health. Most studies have examined its association with physiological conditions, such as sarcopenia, frailty, and physical function, in older populations. Simultaneously, growing attention is being paid to the clinical relevance of segmental PhAs for future applications.

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Background: Given the widespread prevalence of breast cancer as a global malignancy, there is a compelling need to delve into its risk determinants.

Objective: This study aims to investigate the potential relationship between indicators of left-handedness and breast cancer, employing systematic review, meta-analysis, and Mendelian randomization methods.

Design: Systematic review and meta-analysis.

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Study Design: A prospective study.

Purpose: To diagnose scoliosis, a visit to the hospital for radiography is typically necessary. In such cases, children with scoliosis are exposed to radiation, which may place their health at risk.

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  • The study investigates gender dysphoria (GD) in children and adolescents in Singapore, aiming to understand its prevalence and related factors.
  • 107 participants were reviewed, showing an overall prevalence of 0.019%, with a noted increase in incidence rates from 2017 to 2021 and a significant delay in seeking help.
  • The findings emphasize the need for culturally sensitive support for individuals with GD in Asia, highlighting the importance of a holistic approach to their well-being.
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  • - This study explored how the location of re-entry tears affects blood flow and pressure in uncomplicated type B aortic dissection using computer simulations based on CT images.
  • - The simulations showed that models with re-entry tears generally had lower blood pressure and wall shear stress compared to those without, especially when the tear was near the end of the false lumen.
  • - The findings could help inform fenestration surgery in these patients, but more research with a larger patient pool is needed to validate the results.
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  • This study explored how gait (walking pattern) in adolescents with idiopathic scoliosis relates to their spinal alignment, comparing 80 AIS patients to 80 healthy controls.
  • Results showed significant differences in multiple gait metrics and spinal alignment characteristics between the two groups, particularly in factors like gait speed and thoracic kyphosis.
  • Correlation analysis indicated that certain spinal alignment parameters (like pelvic tilt and sacral slope) closely predict aspects of gait, especially step length and gait asymmetry among AIS patients.
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sp. nov. is described from decaying wood submerged in a freshwater stream in Taiwan.

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  • The study evaluated the reliability and validity of the Korean version of the Scoliosis Japanese Questionnaire-27 (SJ-27) by translating and adapting it for Korean-speaking patients.
  • It involved administering the Korean SJ-27 along with the validated Scoliosis Research Society-22 (SRS-22) to 140 patients with idiopathic scoliosis in braces.
  • Results showed high reliability and internal consistency of the SJ-27, with significant correlations to the SRS-22, confirming it as a suitable tool for assessing scoliosis outcomes among these patients.
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Background: Diabetes and prediabetes are diagnosed differentially by Western and Chinese medicine. While Western medicine uses objective laboratory analysis of biochemical parameters to define the severity of diabetes and prediabetes, Chinese medicine uses a comprehensive approach that integrates observation, inquiry, pulse palpation, and tongue diagnosis. The medical information collected is then categorized into different syndromes.

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  • A new AI model was created to predict knee implant sizes for surgeries, making the process faster and easier for surgeons.
  • The model was trained on x-ray images from 714 patients and used data augmentation to enhance training data without relying on clinical or demographic info.
  • Results showed the model had high accuracy, with micro F1-scores of 0.91 for femur and 0.87 for tibia, indicating its potential to streamline preoperative procedures in knee surgeries.
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In recent years, finite element analysis (FEA) has been instrumental in comparing the biomechanical stability of various implants for femur fracture treatment and in studying the advantages and disadvantages of different surgical techniques. This analysis has proven helpful for enhancing clinical treatment outcomes. Therefore, this study aimed to numerically analyze fixed stability according to location using FEA.

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Rho/Rac of plant (ROP) GTPases are plant-specific proteins that function as molecular switches, activated by guanine nucleotide exchange factors (GEFs) and inactivated by GTPase-activating proteins (GAPs). The bryophyte Marchantia polymorpha contains single copies of ROP (MpROP), GEFs [ROPGEF and SPIKE (SPK)] and GAPs [ROPGAP and ROP ENHANCER (REN)]. MpROP regulates the development of various tissues and organs, such as rhizoids, gemmae and air chambers.

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The root cap secretes mucilage and sheds border cells (border-like cells, BLCs) in Arabidopsis (Arabidopsis thaliana). These mucilage and root cap-derived cells form a defensive barrier against soil pathogens. BEARSKIN1 (BRN1) and BRN2 are 2 homologous NAM, ATAF1/2, and CUC2 (NAC) family transcription factors of Arabidopsis, and mucilage secretion is inhibited in the brn1/2 double mutant.

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  • * Researchers conducted aerial surveys and used binary generalised additive models to analyze the relationship between porpoise sightings and various oceanographic factors at different spatial and temporal scales.
  • * Findings indicated that a coarser spatial scale (40 km) and longer temporal scale yielded better models for understanding porpoise habitat, suggesting that analyzing broad scales can enhance knowledge of species-environment interactions.
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Jazz and improvisation have typically been associated with ideals of freedom and liberty; however, in practice these genres are known to be constrained by entrenched patterns of male domination and gender discrimination. Despite a large number of qualitative accounts evidencing persistent sexism and gender exclusion in the field, there exists a lack of empirical data to assess the scale of this phenomenon and substantiate smaller-scale research on gender inequality. In this paper, we employ boundary theory to report on a quantitative investigation of gender marginalization in jazz and improvisation in the Australian context, positioning gender as a symbolic boundary resulting in the social exclusion and marginalization of gender diverse individuals and women.

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Host plants benefit from legume root nodule symbiosis with nitrogen-fixing bacteria under nitrogen-limiting conditions. In this interaction, the hosts must regulate nodule numbers and distribution patterns to control the degree of symbiosis and maintain root growth functions. The host response to symbiotic bacteria occurs discontinuously but repeatedly at the region behind the tip of the growing roots.

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Introduction: Autism is a neurodevelopmental condition that is increasing in prevalence worldwide. There has been an exponential increase in autism-related research since 2010, when the first Singapore Clinical Practice Guidelines (CPG) on autism was published. Understanding of autism has since evolved to adopt a lifespan approach beyond that of a childhood condition.

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  • Water and carbon are crucial for Earth, but human activities are threatening them, especially through climate change.
  • This study focuses on the potential of constructed wetlands in Malaysia's Paya Indah Wetlands (PIW) to improve both water quality and carbon sequestration.
  • The research demonstrates significant benefits of these wetlands, such as enhancing carbon storage and biodiversity, while highlighting the need for adaptive land management strategies based on varying stakeholder perspectives.
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Intrastromal cell therapy utilizing quiescent corneal stromal keratocytes (qCSKs) from human donor corneas emerges as a promising treatment for corneal opacities, aiming to overcome limitations of traditional surgeries by reducing procedural complexity and donor dependency. This investigation demonstrates the therapeutic efficacy of qCSKs in a male rat model of corneal stromal opacity, underscoring the significance of cell-delivery quality and keratocyte differentiation in mediating corneal opacity resolution and visual function recovery. Quiescent CSKs-treated rats display improvements in escape latency and efficiency compared to wounded, non-treated rats in a Morris water maze, demonstrating improved visual acuity, while stromal fibroblasts-treated rats do not.

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Use of extracorporeal membrane oxygenation (ECMO) for cardiorespiratory failure remains complicated by blood clot formation (thrombosis), triggered by biomaterial surfaces and flow conditions. Thrombosis may result in ECMO circuit changes, cause red blood cell hemolysis, and thromboembolic events. Medical device thrombosis is potentiated by the interplay between biomaterial properties, hemodynamic flow conditions and patient pathology, however, the contribution and importance of these factors are poorly understood because many in vitro models lack the capability to customize material and flow conditions to investigate thrombosis under clinically relevant medical device conditions.

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Few studies have investigated the socioeconomic factors associated with retear after rotator cuff repair. This study aimed to identify the risk factors, including socioeconomic factors, for rotator cuff retear in patients who underwent arthroscopic rotator cuff repair. This retrospective study included 723 patients diagnosed with full-thickness rotator cuff tears who underwent arthroscopic rotator cuff repair from March 2010 to March 2021.

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  • * Meta-analysis found the pooled odds ratio for MT in high BMI individuals was 1.32, but this did not conclusively link obesity to MT, especially in younger participants.
  • * Mendelian randomization analysis revealed that a genetically higher BMI significantly correlates with chronic meniscus derangement, suggesting a causal relationship between increased BMI and this type of MT.
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The facet joint contributes to lumbar spine stability as it supports the weight of body along with the intervertebral discs. However, most studies on the causes of degenerative lumbar diseases focus on the intervertebral discs and often overlook the facet joints. This study aimed to investigate the impact of facet joint degeneration on the degenerative changes and diseases of the lumbar spine.

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Background: Knee osteoarthritis (KOA) is one of most prevalent and fastest-growing causes of pain, impaired mobility, and poor quality of life in the rapidly aging population worldwide. There is a lack of high-quality evidence on the efficacy of traditional Chinese medicine (TCM), particularly acupuncture, and a lack of KOA practice guidelines that are tailored to unique population demographics and tropical climates.

Objective: Our HARMOKnee (Heat and Acupuncture to Manage Osteoarthritis of the Knee) trial aims to address these gaps by evaluating the short- and medium-term clinical and cost-effectiveness of acupuncture with heat therapy in addition to standard care, compared to standard care alone.

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