Publications by authors named "Goh Eun Chung"

This study evaluated the impact of differing false positive (FP) rates in two computer-aided detection (CADe) systems on the clinical effectiveness of artificial intelligence (AI)-assisted colonoscopy. The primary outcomes were adenoma detection rate (ADR) and adenomas per colonoscopy (APC). The ADR in the control, system A (3.

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Background And Aims: Nonalcoholic fatty liver disease (NAFLD) is one of the most common liver diseases. There are no universally accepted models that accurately predict time to onset of NAFLD. Machine learning (ML) models may allow prediction of such time-to-event (ie, survival) outcomes.

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  • The study explored the link between nonalcoholic fatty liver disease (NAFLD) and the risk of developing atrial fibrillation (AF), considering factors such as age and liver fibrosis.
  • Researchers analyzed data from over 3 million participants, categorizing them based on their NAFLD status and identifying new cases of AF over a median follow-up of 9.3 years.
  • The findings indicated that the risk of new-onset AF significantly increased with both the severity of NAFLD and the presence of advanced fibrosis, particularly among younger individuals aged 20-29.
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  • A study was conducted to explore how user experience and characteristics of polyps affect interactions with computer-aided detection (CADe) systems during colonoscopy.
  • The CADe system, built using YOLOv4 and trained on nearly 18,000 images, showed an improvement in polyp detection accuracy from 69.7% to 77.7% when assisted by CADe, although misdetections could decrease accuracy.
  • The results indicated that less experienced users (like nurses) benefited more from CADe assistance compared to experts, and while overall sensitivity improved for easier polyp detection, it was lower for more challenging lesions like sessile serrated lesions (SSLs).
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  • - Genome-wide association studies identified genetic variants linked to nonalcoholic fatty liver disease (NAFLD), leading to the introduction of metabolic dysfunction-associated fatty liver disease (MAFLD) to better emphasize metabolic issues.
  • - A study involving 2,282 MAFLD subjects and 4,669 controls from a Korean population revealed significant associations between specific single-nucleotide polymorphisms (SNPs) in the PNPLA3 and GATAD2A genes with MAFLD and its subtypes.
  • - The findings highlighted that SNPs rs738409 and rs3810622 in PNPLA3 were notably linked to different MAFLD categories, including overweight/obese-MAFLD and metabolic dysfunction
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  • A study was conducted to explore the relationship between serum gamma-glutamyl transferase (GGT) levels and mortality rates in patients with type 2 diabetes, utilizing a large Korean health-screening database.
  • Out of nearly 10 million participants observed over an average of 8.1 years, higher GGT levels were linked to increased all-cause mortality and specific causes of death, such as cardiovascular diseases, cancer, and liver disease.
  • The findings suggest that measuring serum GGT levels could be beneficial for evaluating mortality risk in individuals with type 2 diabetes.
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Recognizing anatomical sections during colonoscopy is crucial for diagnosing colonic diseases and generating accurate reports. While recent studies have endeavored to identify anatomical regions of the colon using deep learning, the deformable anatomical characteristics of the colon pose challenges for establishing a reliable localization system. This study presents a system utilizing 100 colonoscopy videos, combining density clustering and deep learning.

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Background: Non-alcoholic fatty liver disease (NAFLD) is a major contributor to liver diseases globally, yet there are limited studies investigating the impact of diet and lifestyle factors on its development. This study aimed to examine the association between the prevalence of NAFLD and predicted pro-inflammatory high-sensitivity C-reactive protein (hs-CRP) score.

Methods: We included 1,076 Korean adults who underwent a medical examination at the Seoul National University Hospital Gangnam Healthcare Center in Korea between May and December 2011 and updated in 2021.

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Article Synopsis
  • The study explored lean nonalcoholic fatty liver disease (NAFLD), revealing that it occurs in about 21.6% of individuals with NAFLD and 18.5% among lean participants specifically, suggesting a unique pathophysiology compared to obese NAFLD.
  • Among those with lean NAFLD, metabolic syndrome and diabetes were noted at rates of 12.4% and 10.4%, indicating some metabolic association in about 20.1% of cases.
  • Despite identifying certain genetic variants linked to lean NAFLD, a significant proportion of cases (approximately 32.1%) weren't associated with known genetic or metabolic factors, highlighting the need for further research to uncover additional risk factors
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Background And Aims: The incidence of early-onset colorectal cancer (EO-CRC, diagnosed before 50 years of age) has increased in recent decades. The aim of this study was to investigate the association between changes in obesity status and EO-CRC risk.

Methods: From a nationwide population-based cohort, individuals <50 years old who participated in the national health checkup program in both 2009 and 2011 were included.

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Introduction: Although an association between metabolic dysfunction-associated fatty liver disease (MAFLD) and cardiovascular disease or overall mortality has been reported, it is unclear whether there is an association between MAFLD and cancer incidence or mortality. We aimed to investigate the differential risk of all- and site-specific cancer incidence and mortality according to MAFLD subgroups categorized by additional etiologies of liver disease.

Methods: Using the Korean National Health Insurance Service database, we stratified the participants into three groups: (1) single-etiology MAFLD (S-MAFLD) or MAFLD of pure metabolic origin; (2) mixed-etiology MAFLD (M-MAFLD) or MAFLD with additional etiological factor(s) (i.

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Background: Alcohol and diabetes are known risk factors for hepatocellular carcinoma (HCC); however, it is unclear whether the association between alcohol consumption and HCC risk differs by fasting serum glucose level and diabetes. We investigated the dose-response relationship between alcohol consumption and the risk of HCC according to glycemic status.

Methods And Findings: This population-based observational cohort study included patients who underwent general health checkups in 2009 using the Korean National Health Insurance Service Database.

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Obesity is a risk factor for colorectal cancer. However, the effect of body weight change on colorectal cancer is uncertain. This study aimed to investigate the relationship between difference in body mass index and the risk of colorectal cancer.

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Background And Purpose: The association between fatty liver and fracture risk has not been firmly established. In this study, we investigated the relationship between the fatty liver index (FLI) and the incidence of fractures among individuals ≥50 years of age, using a nationwide population-based cohort.

Methods: Data from the Korean National Health Insurance System between January 2009 and December 2019 were analyzed using the Cox proportional hazards model.

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Objective: The effects of nonalcoholic fatty liver disease on the risk of end-stage renal disease (ESRD) remain unclear. We investigated the association between the fatty liver index (FLI) and risk of ESRD in patients with type 2 diabetes.

Methods: This population-based observational cohort study enrolled patients with diabetes who underwent health screening between 2009 and 2012 and utilized data from the Korean National Health Insurance Services.

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Article Synopsis
  • Confusion in high and low confidence decisions during optical diagnosis complicates its use in clinical settings, prompting a study on the impact of a 3-second decision rule for endoscopists.
  • The study involved eight gastroenterologists, comparing standard optical diagnosis with a 3-second rule over different phases, examining decision accuracy and performance metrics.
  • Results showed noteworthy improvements in confidence accuracy for nonexperts, while experts showed slight enhancements, indicating the rule's effectiveness, particularly for those with less experience.
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Although the association of nonalcoholic fatty liver disease (NAFLD) with obesity or sarcopenia is known, few studies have investigated the combined effect of various body composition parameters on the risk of NAFLD. Thus, the aim of this study was to evaluate effects of interactions between various body composition parameters, including obesity, visceral adiposity, and sarcopenia, on NAFLD. Data of subjects who underwent health checkups between 2010 and December 2020 were retrospectively analyzed.

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Population-based data regarding the prognostic implication of gamma-glutamyl transferase (GGT) have been inconsistent. We examined the association of GGT with all-cause and disease-specific mortality. Using the Korean nationwide database, we included 9,687,066 subjects without viral hepatitis or cirrhosis who underwent a health examination in 2009.

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Background: Metabolic-associated fatty liver disease (MAFLD) encompasses diverse disease groups with potentially heterogeneous clinical outcomes. We investigated the risk of all-cause and disease-specific mortality in MAFLD subgroups.

Methods: Using the Korean National Health Insurance Service database, participants were divided into four subgroups: no MAFLD, MAFLD-diabetes, MAFLD-overweight/obese, and MAFLD-lean.

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Background: Type 2 diabetes and non-alcoholic fatty liver disease (NAFLD) commonly coexist. However, NAFLD's effect on mortality in Asian patients with type 2 diabetes awaits full elucidation. Therefore, we examined NAFLD-related all-cause and cause-specific mortality in a nationwide Asian population with type 2 diabetes.

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Objective: Although the incidence of colorectal adenomas increases with obesity, the role of various body compositions is still unknown. We aimed to determine which body composition best reflects the risk of colorectal adenomas.

Methods: Patients aged 50-75 years who underwent colonoscopy and a bioelectrical impedance analysis (BIA) for a health check-up from 2017 to 2019 were retrospectively enrolled.

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Background: Metabolic (dysfunction)-associated fatty liver disease (MAFLD) emphasizes the metabolic dysfunction in nonalcoholic fatty liver disease (NAFLD). Although the relationship between low muscle mass and NAFLD has been suggested, the effect of MAFLD on low muscle mass is yet to be investigated. In this study, we examined the relationship between MAFLD and low muscle mass in an asymptomatic Korean population.

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Background: Hepatitis B virus (HBV) infection remains a threat to global public health. Serum hepatitis B surface antigen (HBsAg) has been used in screening for HBV infection. Quantitative HBsAg assays are useful for monitoring the natural history of HBV infection and its response to therapy.

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Aim: A link between low muscle mass and arterial stiffness is not always consistent. In this study, we aimed to evaluate the clinical significance of low skeletal muscle mass in relation to arterial stiffness measured by the cardio-ankle vascular index (CAVI).

Methods: A total of 2,561 asymptomatic Korean subjects who underwent bioelectrical impedance analysis (BIA) and CAVI were included for analysis.

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