Publications by authors named "Gogce C Crynen"
Long-term memory formation requires anterograde transport of proteins from the soma of a neuron to its distal synaptic terminals. This allows new synaptic connections to be grown and existing ones remodeled. However, we do not yet know which proteins are transported to synapses in response to activity and temporal regulation.
View Article and Find Full Text PDFHydrogen/Deuterium Exchange (HDX) coupled with Mass Spectrometry (HDX-MS) is a sensitive and robust method to probe protein conformational changes and protein-ligand interactions. HDX-MS relies on successful proteolytic digestion of target proteins under acidic conditions to localize perturbations in exchange behavior to protein structure. The ability of the protease to produce small peptides and overlapping fragments and provide sufficient coverage of the protein sequence is essential for localizing regions of interest.
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- - RIG-I plays a crucial role in the immune response by recognizing viral RNAs and its mutations (C268F and E373A) disrupt its normal function, leading to excessive signaling that can cause autoimmune diseases.
- - The research investigates how RIG-I incorrectly identifies cellular RNAs with special modifications (7-methylguanosine and Cap1), which weakens its activation and response to these RNAs compared to viral ones.
- - The study finds that certain mutations can restore RIG-I's interaction with RNA and its signaling pathways, but others lock RIG-I in an active state, causing overactive immune responses even without viral presence.
This systematic review examined the association between genetics and risk for sustaining a traumatic brain injury. We retrieved articles published in English from 1980 to July 2016 obtained from the online databases PubMed, PsycINFO, MEDLINE, Embase, and Web of Science. In total 5903 articles were identified, 77 underwent full-text screening, and 6 were included in this review.
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