Publications by authors named "Goenuel Vardar"
Oxadiazole compounds are of great interest because they have a range of biological activities ranging from antioxidants to anticancer agents. Against this background, we wanted to demonstrate the antioxidant, enzyme inhibitory, and anticancer effects of 5(4-hydroxyphenyl)-2-(N-phenylamino)-1,3,4-oxadiazole (Hppo). Antioxidant abilities were measured through free radical scavenging and reducing power tests.
View Article and Find Full Text PDFIntroduction: Transcatheter mitral valve-in-valve replacement (TMVR ViV) is becoming a favorable, less invasive procedure among high-risk patients to manage mitral valve dysfunction. We aimed to investigate the trends of the predictors and outcomes of the procedure.
Methods: The national inpatient sample databases of 2016-2020 were analyzed using STATA 17 software and ICD-10 codes for TMVR ViV, with stratification for mitral stenosis (MS) or Mitral regurgitation (MR) as etiology for prosthetic valve dysfunction.
GM1 gangliosidosis is an ultra-rare inherited neurodegenerative lysosomal storage disorder caused by biallelic mutations in the gene. GM1 is uniformly fatal and has no approved therapies, although clinical trials investigating gene therapy as a potential treatment for this condition are underway. Novel outcome measures or biomarkers demonstrating the longitudinal effects of GM1 and potential recovery due to therapeutic intervention are urgently needed to establish efficacy of potential therapeutics.
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- - Peritoneal malignancies are tumors that arise from the peritoneum, including both primary tumors (like mesothelioma) and secondary tumors that spread from other cancer sites, such as the gastrointestinal tract or gynecological areas.
- - The treatment approach is shifting from traditional palliative care to a multimodal strategy that combines cytoreductive surgery with hyperthermic intraperitoneal chemotherapy, which has led to improved survival rates.
- - Imaging plays a critical role in diagnosing and managing these malignancies, using methods like CT, MRI, and PET to help in staging, monitoring therapy response, and selecting appropriate patients based on tumor burden and treatment outcomes.
Article Synopsis
- GM1-gangliosidosis (GM1) causes significant brain degeneration, making it difficult to use automated MRI techniques for brain volume analysis. An effective standardized segmentation protocol was created to analyze MRIs from patients with type II GM1.
- A study involving 25 MRIs from 22 patients assessed the reliability of this segmentation method, focusing on various brain structures and evaluating the consistency between different raters.
- Results showed that the technique had good inter- and intra-rater reliability, especially for juvenile patients, which can enhance future research and understanding of the disease's progression over time.
Modifying the interfacial dynamics of oleosome (lipid droplet) membrane using curcumin.
J Colloid Interface Sci
January 2025
Article Synopsis
- Oleosomes are lipid droplets that store energy and have a membrane made of phospholipids and proteins, which can carry therapeutic substances.
- The study looked at how curcumin, a compound that can be loaded into oleosomes, affects the mechanical properties of their membranes.
- Results showed that curcumin increases interactions within the membrane, potentially allowing for better-designed oleosome-based treatments.
Article Synopsis
- Trillions of microbes in the human mouth act as a crucial organ, but there's a lack of understanding about oral microbiomes in underrepresented ethnic groups in the U.S. like Hispanics, Blacks, and Asians.
- The study uses advanced sequencing to examine bacterial communities in saliva and plaque from 26 healthy individuals in South Florida, a culturally diverse area.
- Findings reveal notable differences in microbial composition based on factors like mouth location, sex, and gingival health, underscoring the importance of including a diverse range of populations in oral microbiome research.
Article Synopsis
- - Neurological diseases caused by single gene defects can be treated through AAV-mediated gene therapy, but delivering this therapy to the brain is difficult because of the blood-brain barrier.
- - Advanced techniques, like convection-enhanced delivery and image-guided methods to cerebrospinal fluid spaces, allow for precise gene therapy delivery to target specific brain areas.
- - Neuroimaging methods, including MRI and fMRI, are crucial for both delivering AAV vectors and monitoring the effectiveness of the gene therapy over time.
Unlabelled: Mechanical stimulus to the multicellular bone unit (MBU) plays a key role in normal bone remodeling, whereas disuse osteoporosis, for example, represents loss of bone owing to lack of mechanical stresses. The analogy can be applied to a variety of pathogenic bone lytic complications, including periodontitis, in which local mechanical stress appears to be diminished. The activation of mechanosensitive Piezo1 Ca channel expressed by osteoblasts and osteocytes in the MBU elicits the osteogenic signals in those cells.
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- Foreign bodies in the lacrimal drainage system can lead to complications and can come from various sources, making them challenging to deal with.
- A 57-year-old woman experienced excessive tearing in her right eye, prompting a diagnosis of an obstruction in the nasolacrimal duct and leading to surgery.
- During the surgery, an unusual polyp-like structure was discovered and later identified as an organic foreign body, highlighting the need for thorough analysis and teamwork in diagnosing rare cases.
Tactile Weight Rendering: A Review for Researchers and Developers.
IEEE Trans Haptics
September 2024
Article Synopsis
- Haptic rendering of weight is crucial for realistic interactions with objects in virtual environments, traditionally approached through kinesthetic devices but now enhanced with tactile interfaces targeting the skin.
- The study categorizes current tactile weight rendering methods into asymmetric vibration and skin stretch, each further broken down by device mechanisms.
- A comparison of these methods reveals that while asymmetric vibration devices are compact, skin stretch devices offer better mechanical and perceptual benefits for accurate weight rendering, highlighting areas for future research and development.
Article Synopsis
- OC-STAMP is crucial for the formation of osteoclasts, which are cells that break down bone, and targeting it may offer a new way to treat bone loss diseases with fewer side effects.
- Researchers created two types of gels to deliver small RNA molecules aimed at silencing OC-STAMP, finding that one gel (C12-GD-Spe) was more effective in decreasing OC-STAMP activity.
- Tests in mice showed that injecting the C12-GD-Spe gel with siRNA reduced bone loss from conditions like periodontitis, highlighting OC-STAMP as a potential target for new therapies in bone repair.
The present study aimed to determine the dose-response relationship between targeted nanocarriers released from a novel, sustained release formulation and their ability to specifically deplete cells responsible for the development of posterior capsular opacification (PCO) in month-long, dynamic cell cultures. Injectable, thermosensitive poly(D,L-lactic-co-glycolic acid)-b-poly(ethylene glycol)-b-poly(D,L-lactic-co-glycolic acid) triblock copolymer hydrogels were loaded with either a low or a high dose of doxorubicin-loaded antibody-targeted nanocarriers (G8:3DNA:Dox). Human rhabdomyosarcoma cells, selected for their expression of PCO marker brain-specific angiogenesis inhibitor 1 (BAI1), were kept under dynamic media flow and received either a low or high dose of nanocarriers.
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- Chest radiotherapy (C-XRT) can lead to complications such as aortic stenosis, which often necessitates transcatheter aortic valve replacement (TAVR), but data on outcomes for C-XRT survivors are limited.
- A national inpatient study from 2016 to 2020 identified 515 patients with a history of C-XRT who underwent TAVR, comparing their outcomes to matched controls without C-XRT.
- The results indicated that C-XRT patients had lower in-hospital mortality, shorter hospital stays, reduced total charges, and fewer complications, highlighting a potential advantage in TAVR outcomes for these patients.
Article Synopsis
- The study investigates how eco-friendly silver nanoparticles (AgNPs) influence the production of secondary metabolites in Pimpinella anisum L. (anise), a plant whose metabolites are difficult to synthesize chemically.
- Different concentrations of AgNPs were tested, showing that lower doses (1 and 5 mg/L) induced stress but ultimately led to increased production of essential fatty acids, while higher doses (10 and 20 mg/L) resulted in notable toxicity.
- The findings suggest that AgNPs can effectively enhance the synthesis of valuable metabolites like omega fatty acids and phenolic compounds in anise, highlighting their potential as plant elicitors in agriculture and pharmaceuticals.
Article Synopsis
- The study aims to develop and evaluate a mobile app designed to improve physical and emotional well-being for patients with gynecological cancer undergoing chemotherapy.
- It will use a randomized controlled design to compare outcomes between two groups: one using the app (intervention) and one that does not (control), involving 52 participants.
- Though currently in the protocol stage, the app is expected to offer valuable resources like real patient stories, multimedia support, and direct access to counseling, which may enhance coping with cancer treatment.
Article Synopsis
- The SNARE proteins are vital for neurotransmitter release at synapses, but their exact role in managing both rapid release and vesicle availability is still not fully understood.
- Researchers created chimeric proteins by swapping parts of the SNARE domain between two proteins, STX1A and STX2, to study these functions in mouse neurons lacking STX1.
- Results showed that changes in the C-terminal segment of the SNARE domain influenced the readily releasable pool of vesicles and the speed of neurotransmitter release, highlighting its importance in synaptic function.
Article Synopsis
- Computationally hard combinatorial optimization problems (COPs) are common in various applications, and existing solutions like digital annealers and quantum systems face issues related to memory, scalability, and applicability.
- The study introduces a ferroelectric field effect transistor (FeFET) based compute-in-memory (CiM) annealer designed to address these challenges by converting COPs into quadratic unconstrained binary optimization (QUBO) formats and accelerating key calculations.
- Experimental results show that this FeFET CiM annealer can significantly reduce chip size by 75% for Max-Cut problems, while also delivering up to 27% better solutions and doubling the speed compared to traditional simulated annealing methods.
The mechanism of encapsulating curcumin into oleosomes (Lipid Droplets).
Colloids Surf B Biointerfaces
April 2024
Article Synopsis
- * The study focuses on plant-derived lipid droplets, or oleosomes, and their ability to carry hydrophobic therapeutics like curcumin, showing that curcumin can easily move into these droplets.
- * Research techniques demonstrated that curcumin accumulates both at the oleosome interface and within its core, revealing important insights into how plant lipid droplets can be utilized as drug carriers.
Article Synopsis
- The study aimed to compare cancer-related concerns between cancer survivors who completed treatment and those still undergoing it, focusing on various affecting factors.
- Data were collected from 350 Turkish cancer survivors using online surveys, leading to a conclusion that those who completed treatment had higher levels of concerns, particularly among women and those with recent diagnoses.
- The findings highlight the importance of addressing the psychosocial needs of cancer survivors, emphasizing that healthcare providers should offer comprehensive care that goes beyond just physical treatment.
Objective: This study examined systemic inflammatory indices and "Hemoglobin, Albumin, Lymphocyte, Platelet (HALP) scores" in neonates with hypoxic-ischemic encephalopathy (HIE).
Methods: A total of 43 neonates with moderate-to-severe HIE at 36 weeks' gestation were assessed. Systemic inflammatory markers were measured before HT commenced within 0-6 h after birth and between 60 and 72 h during and after therapy or before adjusting for hypothermia.
Article Synopsis
- * The study involved interviews with 40 Turkish female officers to explore the various challenges they encounter, leading to the identification of 50 different issues categorized into 10 major themes.
- * The findings highlight unique obstacles these women face, providing insights that can inform policies aimed at empowering women within the industry.
Non-volatile memories (NVMs) have the potential to reshape next-generation memory systems because of their promising properties of near-zero leakage power consumption, high density and non-volatility. However, NVMs also face critical security threats that exploit the non-volatile property. Compared to volatile memory, the capability of retaining data even after power down makes NVM more vulnerable.
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