Experimental investigation on the carob extraction using arrhenius approach and response surface.

Environmental problems have increased the need for sustainable agricultural practices that conserve water and energy. Carob, an eco-friendly crop with multiple health benefits, holds the potential for economic evaluation. This study investigates the carob molasses extraction process, focusing on the influence of temperature and water quantity on the diffusion coefficient.

The impact of artifact levels on intra- and interobserver agreement in pediatric urodynamic traces.

Introduction: In pediatric urology, urodynamic studies are considered the most reliable method for assessing the function of the lower urinary tract. These evaluations play a particularly important role in guiding treatment decisions for neurogenic bladder conditions.

Objective: The aim of this study is to assess the impact of artifacts on the interobserver and intraobserver agreement in the interpretation of pediatric urodynamic traces.

Chemical profiling and biological activity evaluation of propolis from Çayeli-Rize, Eastern Black Sea Region, Anatolia.

The constituents of the aqueous, ethanol, hexane, and methanol extracts of Anatolian propolis collected from the Eastern Black Sea Region (Çayeli-Rize) were investigated by GC-MS, HPLC and AAS. Interestingly, lactulose has been identified. Ten phenolic compounds, namely caffeic acid, ferulic acid, rutin, taxifolin, quercetin, kaempferol, apigenin, silicristin, silibinin and gallic acid were determined.

Prenatal exposure to endocrine disrupting chemicals and the association with behavioural difficulties in 7-year-old children in the SELMA study.

Background: Endocrine disrupting chemicals (EDCs) can cross the placenta and thereby expose the fetus, which may lead to developmental consequences. It is still unclear which chemicals are of concern regarding neurodevelopment and specifically behaviour, when being exposed to a mixture.

Objective: The objective is to determine associations between prenatal exposure to EDCs and behavioural difficulties.

Anorectal manometry and urodynamics in children with spina bifida: can we predict the colonic dysmotility from bladder dysfunction?

Introduction: Spina bifida is a condition that impacts the development of the neural tube leading to urological and gastrointestinal symptoms. Both systems are influenced together due to their shared innervation and embryological origin. Despite its impact on health and well-being there has been limited research on the relationship between manometry results and urodynamic tests, in this patient population.

PI3K/mTOR Inhibitor VS-5584 Alters Expression of WNT Signaling Genes and Induces Apoptosis in Lung Adenocarcinoma Cells: In Vitro and In Silico Insight.

Lung cancer (LC) accounts for approximately 25% of all cancer cases, with 80-85% of these being non-small cell lung cancer (NSCLC). VS-5584 is a novel anti-cancer agent that specifically inhibits mTORC1/2 and class I PI3K isoforms. There is cross-talk between the PI3K-Akt-mTOR and WNT signaling pathways that are abnormally activated in NSCLC.

Advancing Prognostic Prediction in Pediatric Trauma: The Role of Inflammatory Markers.

Background: This study aimed to evaluate the prognostic value of various inflammatory markers and indices derived from complete blood counts in predicting mortality among pediatric trauma patients admitted to the Pediatric Intensive Care Unit (PICU).

Patients And Methods: We designed a single-center retrospective study that included 165 pediatric trauma patients in the PICU between January 2020 and June 2024.

Results: Of 165 patients, 108 (69.

Deposition simulations of realistic dosages in patient-specific airways with two- and four-way coupling.

Inhalers spray over 100 million drug particles into the mouth, where a significant portion of the drug may deposit. Understanding how the complex interplay between particle and solid phases influence deposition is crucial for optimising treatments. Existing modelling studies neglect any effect of particle momentum on the fluid (one-way coupling), which may cause poor prediction of forces acting on particles.

Sustainable land-based IMTA: Holistic management of finfish, mussel, and macroalgae interactions, emphasizing water quality and nutrient dynamics.

This research aims to minimize the environmental impact and promote the sustainability of aquaculture by optimizing nutrient dynamics, improving water quality and enhancing species growth performance through a land-based Integrated Multi-Trophic Aquaculture (IMTA) system. The study focused on Black Sea trout (Salmo labrax), Mediterranean mussel (Mytilus galloprovincialis), and sea lettuce (Ulva lactuca), reared in interconnected tanks using Black Sea water over 90 days. The Black Sea trout more than doubled in size to 333.

Clinical Perspectives and Novel Preclinical Models of Malignant Pleural Mesothelioma: A Critical Review.

Pleural mesothelioma (PM), a rare malignant tumor explicitly associated with asbestos and erionite exposures, has become a global health problem due to limited treatment options and a poor prognosis, in which the median life expectancy varies depending on the method of treatment. However, the importance of early diagnosis is emphasized, and the practical methods have not matured yet. This study provides a critical overview of PM, addressing various aspects like epidemiology, etiology, diagnosis, treatment options, and the potential use of advanced technologies like microfluidic chip-based models for research and diagnosis.

Does Adding TENS to Pelvic Floor Rehabilitation Effect on Urodynamics and Clinical Results in Children With Spina Bifida?

Introduction: Children with spina bifida (SB) experience a reduced quality of life due to neurogenic bladder dysfunction and the risk of renal failure later in life. Pelvic floor rehabilitation (PFR) and transcutaneous electrical nerve stimulation (TENS) have gained prominence in recent years due to their positive effects in treating different types of bladder issues in both adults and children. Our study aims to investigate the effects of using these two methods together in children with SB and to delineate their potential value for clinical practice.

Cardioprotective effects of H3 receptor activation could be double-sided: insights from isoproterenol-induced cardiac injury.

Histamine H3 receptors (H3Rs) are known to modulate neurotransmitter release in the nervous system, but their role in cardiac injury remains unclear. The present study aimed to investigate the cardioprotective role of H3Rs in a mouse model of myocardial injury. Forty BALB/c male mice were divided into four groups: Control (SF), Isoproterenol (ISO), Imetit (IMT), and IMT + ISO.

Comparative Analysis of Burn Injuries in Toddler and Preschool Children: Implications for Triage and Outcome Assessment.

Objective: This study aims to compare the demographic, clinical characteristics, and outcomes of burn injuries in toddler and preschool children, and to validate the American Burn Association (ABA) Burn Triage Decision Matrix in the Turkish pediatric population.

Methods: A retrospective analysis was conducted on 684 pediatric burn patients (494 toddlers, 190 preschoolers) admitted to our burn center over a 5-year period. Variables including gender, burn etiology, burn area, depth, treatment modalities, complications, length of hospital stay, and mortality were analyzed.

Dentin thickness model: A novel method for dental age estimation using panoramic radiography.

The study aims to evaluate the reliability of the novel dentin thickness model based on root parameters when applied to panoramic radiography images of mandibular first molar in the southern Turkish subpopulation. A total of 946 panoramic images were analyzed for the study. The samples were allocated into four age groups: Group 1(between 10 and 18), Group 2(between 19 and 30), Group 3(between 31 and 50), Group 4(between 51 and 78).

The relationship between urodynamic bladder compliance and urinary fibrosis markers in children with neurogenic bladder dysfunction.

Background: Decreased bladder compliance is an important risk factor for upper urinary tract in children with neurogenic bladder dysfunction (NBD). Urodynamics is the gold standard in determining bladder compliance.

Objective: To investigate the relationship between low bladder compliance and urinary fibrosis markers in NBD.

Comparison of the Grades of Fatty Liver Disease With Perioperative Risk Factors in Patients With Laparoscopic Sleeve Gastrectomy.

Background Obesity is a global healthcare problem, and nonalcoholic fatty liver disease (NAFLD) is a commonly observed comorbid disease in the bariatric population. This study evaluated the relationship between NAFLD and various risk factors, including demographic, biochemical, and comorbid conditions in patients undergoing laparoscopic sleeve gastrectomy (LSG). Material and methods This retrospective data analysis study included patients who underwent LSG between August 2023 and 2024.

Unexpected far-field deformation of the 2023 Kahramanmaraş earthquakes revealed by space geodesy.

The spatiotemporal pattern of surface displacements from large earthquakes provides crucial insights about the deformation of Earth's crust at various scales and the interactions among tectonic plates. However, the lack of extensive and large-scale geodetic networks near such seismic events hinders our thorough understanding of the large-scale crustal deformation resulting from earthquakes. Using Türkiye's extensive and continuous global navigation satellite system (GNSS) network during the moment magnitude 7.

Preparation of dual drug-loaded polymer nanoconjugate to enhance treatment efficacy for ovarian cancer cells.

Ovarian cancer is the deadliest gynecological malignancy, representing 2.5 % of all female cancers and accounting for 5 % of female cancer-related fatalities. Despite numerous strategies in its treatment, the disease shows a high recurrence rate and a low survival rate.