Publications by authors named "Goenaga M"
Background: Coagulase-negative staphylococci (CoNS) are an increasingly common cause of infective endocarditis (IE) and lack recent data from large studies.
Objectives: Our aim was to describe the epidemiology, clinical characteristics, and outcomes of staphylococcal IE in a contemporary nationwide cohort study, while comparing coagulase-negative staphylococcal IE (CoNSIE) to IE from Staphylococcus aureus (SAIE), and among IE caused by Staphylococcus epidermidis (SE), S. lugdunensis (SL), and other CoNS.
Article Synopsis
- A study of infective endocarditis (IE) in Spain revealed that 19.8% of patients also suffered from acute stroke, with most cases being ischemic strokes.* -
- Patients with stroke had higher risks of complications, surgical needs, and mortality rates compared to those without stroke, indicating more severe health impacts.* -
- Factors like the location of infection and the presence of other medical issues were found to increase the likelihood of stroke and its associated mortality in these patients.*
Epidemiology and Risk Factors of Mycotic Aneurysm in Patients With Infective Endocarditis and the Impact of its Rupture in Outcomes. Analysis of a National Prospective Cohort.
Open Forum Infect Dis
March 2024
Background: Several aspects of the occurrence and management of mycotic aneurysm (MA) in patients with infective endocarditis (IE) have not been studied.
Objectives: To determine the incidence and factors associated with MA presence and rupture and to assess the evolution of those initially unruptured MA.
Methods: Prospective multicenter cohort including all patients with definite IE between January 2008 and December 2020.
Objectives: This study aimed to assess the real use of cefazolin for methicillin-susceptible Staphylococcus aureus (MSSA) infective endocarditis (IE) in the Spanish National Endocarditis Database (GAMES) and to compare it with antistaphylococcal penicillin (ASP).
Methods: Prospective cohort study with retrospective analysis of a cohort of MSSA IE treated with cloxacillin and/or cefazolin. Outcomes assessed were relapse; intra-hospital, overall, and endocarditis-related mortality; and adverse events.
Article Synopsis
- The study investigates the effectiveness and safety of combining beta-lactam and aminoglycoside (C-BA) treatments versus using third-generation cephalosporin alone for endocarditis caused by viridans and gallolyticus group streptococci (VGS-GGS) with penicillin intermediate susceptibility.
- A retrospective analysis of 914 endocarditis cases from 40 Spanish hospitals found that 75.3% were penicillin-susceptible and 24.7% had intermediate susceptibility, with C-BA used in 54.6% of cases.
- The results indicate that cephalosporin monotherapy is effective and associated with lower rates of nephrotoxicity, as it
Executive summary of the consensus statement of the Spanish Society of Infectious Diseases and Clinical Microbiology (SEIMC), Spanish Society of Neurology (SEN), Spanish Society of Immunology (SEI), Spanish Society of Pediatric Infectology (SEIP), Spanish Society of Rheumatology (SER), and Spanish Academy of Dermatology and Venereology (AEDV), on the diagnosis, treatment and prevention of Lyme borreliosis.
Enferm Infecc Microbiol Clin (Engl Ed)
January 2023
The diagnosis of Lyme borreliosis (LB) is based on the epidemiological history, clinical manifestations and microbiological findings in the early disseminated and late phases of the disease. Related to this fact, microbiological diagnostic techniques have recently appeared. Far from facilitating the diagnosis and the clinical-therapeutic management of LB patients, they are generating confusion.
View Article and Find Full Text PDFBackground: Outpatient parenteral antibiotic treatment (OPAT) programs are increasingly used to manage infective endocarditis (IE), but current criteria for indicating OPAT are markedly conservative. We aimed to investigate whether more liberal criteria for indicating OPAT in IE can be safely used.
Methods: This was a prospective multicenter nationwide cohort study (2008-2018).
Background. Infective endocarditis (IE) is a severe condition. Our aim was to describe the profile and prognosis of patients with multivalvular infective endocarditis (MIE) and compare them to single-valve IE (SIE).
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- Infective Endocarditis (IE) is a serious illness, and diabetes mellitus (DM) has been linked to worse outcomes for patients with IE.
- A study analyzing data from the Spanish IE Registry (2008−2020) found that almost 30% of IE patients had DM, with higher in-hospital and one-year mortality rates for those with DM compared to those without.
- The presence of organ damage in DM patients further increases the risks of mortality, indicating that diabetes management is crucial for improving prognosis in these patients.
Article Synopsis
- The study compared infective endocarditis (IE) in children and adolescents to adults, using data from 31 hospitals in Spain between 2008 and 2020.
- Among 5590 patients, only 49 were under 18, with 63.2% having congenital heart disease (CHD), which showed a preference for right-sided IE compared to adults.
- Pediatric patients with CHD experienced a lower rate of heart failure, while those without CHD had clinical profiles similar to adults, including a focus on left-sided IE.
Current data on the frequency and efficacy of linezolid (LNZ) in infective endocarditis (IE) are based on small retrospective series. We used a national database to evaluate the effectiveness of LNZ in IE.This is a retrospective study of IE patients in the Spanish GAMES database who received LNZ.
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- This document is a collaborative effort by three Spanish medical organizations focused on addressing sternal wound infections following surgery.
- A diverse group of specialists, including surgeons, microbiologists, and internal medicine doctors, has come together to formulate this consensus.
- The aim is to create evidence-based guidelines for preventing, diagnosing, and managing post-surgical mediastinitis, ultimately improving patient care and outcomes.
Background: There are several prognostic models to estimate the risk of mortality after surgery for active infective endocarditis (IE). However, these models incorporate different predictors and their performance is uncertain.
Objective: We systematically reviewed and critically appraised all available prediction models of postoperative mortality in patients undergoing surgery for IE, and aggregated them into a meta-model.
Introduction: Mural infective endocarditis (MIE) is a rare type of endovascular infection. We present a comprehensive series of patients with mural endocarditis.
Methods: Patients with infectious endocarditis (IE) from 35 Spanish hospitals were prospectively included in the GAMES registry between 2008 and 2017.
Background: Although group (SAG) endocarditis is considered a severe disease associated with abscess formation and embolic events, there is limited evidence to support this assumption.
Methods: We performed a retrospective analysis of prospectively collected data from consecutive patients with definite SAG endocarditis in 28 centers in Spain and Italy. A comparison between cases due to SAG endocarditis and viridans group streptococci (VGS) or group (SGG) was performed in a 1:2 matched analysis.
Article Synopsis
- * In SOT patients, there were notable findings such as a lower average age, more comorbidities, a higher incidence of healthcare-related IE, and a significant prevalence of Staphylococcus infections.
- * Despite the increased complications, including kidney issues and septic shock, mortality rates for SOT patients were similar to those without SOT, suggesting that while SOT recipients have different challenges, the overall survival outcome is comparable.
We aimed to identify clinical factors associated with recurrent infective endocarditis (IE) episodes. The clinical characteristics of 2816 consecutive patients with definite IE (January 2008-2018) were compared according to the development of a second episode of IE. A total of 2152 out of 2282 (94.
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- * Among the patients, 34% experienced acute heart failure (AHF) and 5% had CS, with CS patients showing higher rates of surgery and in-hospital mortality compared to those without AHF or AHF alone.
- * Key factors linked to developing CS included severe valve regurgitation and certain arrhythmias, while CS patients were more likely to have lower mortality compared to those with septic shock, emphasizing the need for quick diagnosis and surgical intervention.
Objective: To investigate the rate of colorectal neoplasms (CRNs) in patients who have Enterococcus faecalis infective endocarditis (EFIE) with available colonoscopies and to assess whether this is associated with the identification of a focus the infection.
Patients And Methods: Retrospective analysis of data from a prospective multicenter study involving 35 centers who are members of the Grupo de Apoyo para el Manejo de la Endocarditis en España [Support Group for the Management of Infective Endocarditis in Spain] cohort. A specific set of queries regarding information on colonoscopy and histopathology of colorectal diseases was sent to each participating center.
Background: Enterococcal endocarditis (EE) is a growing entity in Western countries. However, quality data from large studies is lacking.
Objectives: The purpose of this study was to describe the characteristics and analyze the prognostic factors of EE in the GAMES cohort.
Objectives: Several risk prediction models have been developed to estimate the risk of mortality after valve surgery for active infective endocarditis (IE), but few external validations have been conducted to assess their accuracy. We previously developed a systematic review and meta-analysis of the impact of IE-specific factors for the in-hospital mortality rate after IE valve surgery, whose obtained pooled estimations were the basis for the development of a new score (APORTEI). The aim of the present study was to assess its prognostic accuracy in a nationwide cohort.
View Article and Find Full Text PDFBackground: Streptococcus tigurinus was recently described as a new streptococcal species within the viridans group streptococci (VGS). The objectives of the present work were to analyse the clinical and microbiological characteristics of S. tigurinus isolated from patients with bacteraemias, to determine the prevalence of S.
View Article and Find Full Text PDFPurpose: The aim of this study was to analyse the characteristics of patients with IE in three groups of age and to assess the ability of age and the Charlson Comorbidity Index (CCI) to predict mortality.
Methods: Prospective cohort study of all patients with IE included in the GAMES Spanish database between 2008 and 2015.Patients were stratified into three age groups:<65 years,65 to 80 years,and ≥ 80 years.
Objectives: Tropheryma whipplei has been detected in 3.5% of the blood culture-negative cases of endocarditis in Spain. Experience in the management of T.
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