Squamous metaplasia of the breast. An ultrastructural and immunologic evaluation.

Squamous metaplasia in the breast is rare. This case of an intracystic papilloma of the breast with prominent squamous change was found by electron microscopy and immunohistochemistry to contain evidence of squamous differentiation within myoepithelial cells. The findings suggest that squamous metaplasia of the breast may result from myoepithelial cell differentiation in a manner analogous to the development of squamous lesions in the cervix and salivary gland.

S-100 staining in the diagnosis of eosinophilic granuloma of lung.

The authors used immunohistochemical staining for S-100 protein to search for Langerhans cells in 7 cases of pulmonary eosinophilic granuloma (EGL) and in 18 cases of other pulmonary processes (including reactive eosinophilic pleuritis, chronic interstitial pneumonias, eosinophilic pneumonia, and nonspecific scars), which can produce diagnostic confusion with EGL. Qualitatively, Langerhans cells were found in almost every disease. However, cases of active or resolving EGL showed greater than 75 such cells/10 high-power fields (hpf), often appearing as densely packed aggregates (a virtually diagnostic feature), while all other conditions, including completely scarred EGL, showed fewer than 35 Langerhans cells/10 hpf, and the cells were scattered through the parenchyma.

Progesterone secreting Sertoli cell tumor of the ovary.

A 33-year-old woman presenting with secondary amenorrhea and galactorrhea was found to have a Sertoli cell tumor of the ovary. The neoplasm also had a sex cord tumor with annular tubules (SCTAT) component. Further investigations revealed that in many respects the patient was endocrinologically pregnant.

Ewing's sarcoma in bones of the hands and feet: a clinicopathologic study and review of the literature.

Review of current data from the Intergroup Ewing's Sarcoma Study (IESS) shows that Ewing's sarcoma (ES) is rare in bones of the hands and feet. Only 12 of 377 evaluable patients in the first two IESS studies had a primary tumor in these small, distal bones. The age distribution was typical for that seen in patients with ES at other sites.

Radiographic appearance of Ewing sarcoma of the hands and feet: report from the Intergroup Ewing Sarcoma Study.

Review of current data from the Intergroup Ewing Sarcoma Study (IESS) shows that Ewing sarcoma is rare in bones of the hands and feet. The 12 patients from the IESS protocols with hand or foot Ewing sarcoma are comparable to those already reported in the literature. With the exception of lesions in the calcaneus, the prognosis for disease-free survival is excellent.

Cellular immunolocalization of S100 protein within fixed tissue sections by monoclonal antibodies.

Monoclonal antibodies (MoAb) that cross-react with the shared epitopes of S100 protein have been prepared from mouse hybridoma cell lines and partially characterized. Nine of these MoAb were applied to sections of formaldehyde-fixed paraffin-embedded human tissues that were stained by immunohistochemical techniques. Three of these MoAb give uniformly and reproducibly positive staining in appropriate cell types when stained by avidin-biotin methods.

Local recurrence, rate and sites of metastases, and time to relapse as a function of treatment regimen, size of primary and surgical history in 62 patients presenting with non-metastatic Ewing's sarcoma of the pelvic bones.

This report reviews the experience of 62 patients who presented between 1972 and 1978 with non-metastatic Ewing's sarcoma of the pelvis and were entered on IESS I. Seventeen patients (27%) developed a local recurrence, 38 patients (61%) demonstrated metastases and 21 (34%) neither. In the dose range 4000 rad to 6000 rad no dose response could be detected for local control of tumor.

Histomorphology of human lung cancer.

We have seen that neoplasms can arise at a number of sites through the lung. They arise from a variety of cells populating these sites. And, specific lesions of different cell types have a variety of biological behaviors.

The pathologic spectrum of small cell carcinoma of the cervix.

Small cell carcinoma of the cervix is a term used to describe several entities including cervical carcinoid, "oat cell" carcinoma, reserve cell carcinoma, and poorly differentiated nonkeratinizing squamous cell carcinoma. The light microscopic, ultrastructural, and clinical features of seven small cell cervical carcinomas are presented in this report. Five tumors in our report were diagnosed as small cell anaplastic or oat cell carcinoma by light microscopy.

Hyperadrenalism in childhood and adolescence.

Hyperadrenalism in childhood and adolescence has unique features that influence diagnosis and management. We reviewed our experience with 18 patients, ranging in age from 18 months to 18 years. Nine had bilateral adrenal hyperplasia, eight had adrenal neoplasms, and one had micronodular hyperplasia.

Bioelectric properties and ion flow across excised human bronchi.

Bioelectric properties and ion transport of excised human segmental/subsegmental bronchi were measured in specimens from 40 patients. Transepithelial electric potential difference (PD), short-circuit current (Isc), and conductance (G), averaged 5.8 mV (lumen negative), 51 microA X cm-2, and 9 mS X cm-2, respectively.

Pulmonary eosinophilic granuloma. 25-year follow-up.

Pulmonary eosinophilic granuloma is an uncommon disease of unknown origin with characteristic pathologic features. Reports of long-term follow-up in this disorder are rare in the literature. We report the course of a patient followed at our institution from diagnostic lung biopsy through autopsy over 25 yrs.

Giant basal cell carcinoma of the vulva.

A giant basal cell carcinoma of the vulva is reported. The lesion was atypical in its large size and gross morphology, therefore making clinical diagnosis difficult. Diagnosis of this lesion is often delayed because of its varied clinical appearance.

Postmenopausal ovarian follicle cyst: an unusual cause of estrogen excess.

Six years after menopause, a 61-year-old woman complained of enlarging, tender breasts. The serum follicle-stimulating hormone level was 62 mIU/ml; the serum estradiol value was 91 pg/ml; and challenge with progesterone, 100 mg i.m.

Ewing's sarcoma of bone: clinicopathologic aspects of 303 cases from the Intergroup Ewing's Sarcoma Study.

Clinicopathologic features of 303 cases of Ewing's sarcoma of bone collected by the Intergroup Ewing's Sarcoma Study group are described. Ewing's sarcoma was found to arise predominantly in the inferior segment of the skeleton in young white patients from 10 to 15 years of age. Of the several recognized histologic patterns, the filagree pattern--an organoid pattern consisting of bicellular strands of tissue separated by filmy vascular stroma--was associated with the lowest survival rates.

Neuroblastoma and the differential diagnosis of small-, round-, blue-cell tumors.

Of the solid tumors of childhood, neuroblastoma--the prototypic small-, round-, blue-cell neoplasm--occurs in the youngest patients and has shown the least predictable biologic behavior and response to therapy. It is often confused clinically and histologically with Wilms' tumor, rhabdomyosarcoma, lymphoma, and especially, Ewing's sarcoma. Certain clinical and histologic features that may be useful in prognosis have been identified, however, and a variety of distinctive light microscopic, electron microscopic, and immunohistochemical features may be useful in differentiating this and related tumors.

Cryosurgery of the fetal ductus arteriosus.

The effects of cryosurgical treatment of the fetal ductus arteriosus (DA) on the structure and function of the neonatal DA are assessed for the first time. A cryosurgical probe, cooled with nitrous oxide, was used to freeze the wall of the DA in 5 fetal lambs. Six fetal lambs were used as control animals.

Cystic partially differentiated nephroblastoma and polycystic Wilms tumor: a spectrum of related clinical and pathologic entities.

Cystic partially differentiated nephroblastoma is a rare neoplasm occurring in young children and demonstrating features of classic nephroblastoma (Wilms tumor) and multilocular cysts. Cystic partially differentiated nephroblastoma actually represents a spectrum of cystic renal tumors in which varying amounts of blastema, stroma and epithelial structures are present. Some of these lesions should, perhaps, be classified more accurately as polycystic nephroblastoma.

The effect of some contrast agents in the lung: an experimental study in the rat and dog.

Radiographic and histologic studies were carried out in rats and dogs after the instillation of Barosperse, Hypaque-35%, metrizamide, MP10013 (a nonionic iodine-containing agent), and isotonic saline into the lungs of these animals. In addition, blood gases were examined using these agents in dogs. Given aspiration of larger quantities of the contrast agents, the nonionic iodine-containing agents (metrizamide and MP10013) were better tolerated and evoked less pulmonary response than either Hypaque-35% or Barosperse.

Hepatic teratomas in children.

This report describes a hepatic teratoma in a newborn child. Microscopic examination showed a predominantly immature teratoma containing tissue representative of all three germ layers. No evidence of malignant tissue was found in the tumor, and no clinical evidence of metastasis was found in the child.

Intramyofiber skeletal muscle invasion in Ewing's sarcoma of bone: clinicopathologic observations from the intergroup Ewing's sarcoma study.

Skeletal muscle may be infiltrated by a variety of invasive or metastatic malignant tumors. In 14 out of 291 cases of Ewing's sarcoma, we observed diagnostic biopsies in which local skeletal muscle fibers contained intrasarcolemmal aggregates of tumor cells. Cases demonstrating local intramyofiber invasion have a higher mitotic count, an increased rate of developing distant metastases, and a decreased survival when compared to cases not demonstrating this skeletal muscle "parasitism.

Congenital alveolar capillary dysplasia--an unusual cause of respiratory distress in the newborn.

The clinical and anatomical features of a patient with an unusual pulmonary malformation, is reported. The clinical course was consistent with the syndrome of persistent fetal circulation; morphologically, however, the patient was found to have a unique form of pulmonary dysplasia. Failure of formation and ingrowth of alveolar capillaries led to absence of normal air-blood barriers in this term infant.