Modeling of Effectiveness of -Substituted Amidrazone Derivatives as Potential Agents against Gram-Positive Bacteria.

Prediction of the antibacterial activity of new chemical compounds is an important task, due to the growing problem of bacterial drug resistance. Generalized linear models (GLMs) were created using 85 amidrazone derivatives based on the results of antimicrobial activity tests, determined as the minimum inhibitory concentration (MIC) against Gram-positive bacteria: , , , , and . For the analysis of compounds characterized by experimentally measured MIC values, we included physicochemical properties (e.