The hepatopulmonary syndrome: radiologic findings in 10 patients.

Objective: The purpose of this study was to review the radiologic manifestations of the hepatopulmonary syndrome.

Materials And Methods: We retrospectively reviewed clinical records, chest radiographs, 99m Tc-macroaggregated albumin (MAA) perfusion lung scans, chest CT scans, and pulmonary angiograms of 10 patients with proven hepatopulmonary syndrome.

Results: Chest radiographs showed basilar, medium-sized (1.

Leukemogenic risk of hydroxyurea therapy in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis.

In polycythemia vera (PV), treatment with chlorambucil and radioactive phosphorus (p32) increases the risk of leukemic transformation from 1% to 13-14%. This risk has been estimated to be 1-5.9% with hydroxyurea (HU) therapy.

Pneumomediastinum: old signs and new signs.

Pneumomediastinum, also known as mediastinal emphysema, represents extraluminal gas in the mediastinum. Pneumomediastinum can lead to pneumothorax, pneumopericardium, pneumoperitoneum, or pneumoretroperitoneum. There are many causes of pneumomediastinum (Table 1) and several radiographic signs: pneumopericardium, continuous diaphragm sign, continuous left hemidiaphragm sign, Naclerio's V sign, V sign at confluence of brachiocephalic veins, ring-around-the-artery sign, thymic spinnaker-sail sign, and extrapleural air sign.

Correction of computed tomography motion artifacts using pixel-specific back-projection.

Cardiac and respiratory motion can cause artifacts in computed tomography scans of the chest. The authors describe a new method for reducing these artifacts called pixel-specific back-projection (PSBP). PSBP reduces artifacts caused by in-plane motion by reconstructing each pixel in a frame of reference that moves with the in-plane motion in the volume being scanned.

Respiratory compensation in projection imaging using a magnification and displacement model.

Respiratory motion during the collection of computed tomography (CT) projections generates structured artifacts and a loss of resolution that can render the scans unusable. This motion is problematic in scans of those patients who cannot suspend respiration, such as the very young or intubated patients. Here, the authors present an algorithm that can be used to reduce motion artifacts in CT scans caused by respiration.

Intrathoracic granulocytic sarcomas.

Recent trends in the treatment of intrathoracic granulocytic sarcoma (IGS) call for an overview of its radiographic manifestations. Nine patients from our institution and a review of 41 from the literature provide the basis of our conclusions on the typical and atypical appearance of IGS. Of the nine patients with IGS, all had chest radiographs, five had computed tomographic (CT) scans, and one had magnetic resonance (MR) scans.

Reptilian sex steroid receptors: amplification, sequence and expression analysis.

Sex steroid hormones secreted by the gonads play a central role in the reproduction of all vertebrates. In addition to direct effects on gametogenesis, sex steroid hormones are important in sexual development, brain organization, and sexual behavior. The actions of sex steroid hormones are mediated primarily by ligand-dependent transcription factors, or receptors which bind to specific sequences of the DNA and alter the transcription rates of nearby genes.

Correlation of multidrug resistance (MDR1) protein expression with functional dye/drug efflux in acute myeloid leukemia by multiparameter flow cytometry: identification of discordant MDR-/efflux+ and MDR1+/efflux- cases.

Resistance to chemotherapy is a major factor limiting successful treatment of acute myeloid leukemia (AML); one of the best characterized drug resistance mechanisms is extrusion of drugs by the energy-dependent multidrug resistance (MDR1) transport protein. Expression of MDR1 is common in AML and has been linked to lower remission induction rates and decreased remission durations. Because MDR1 efflux function may be modified by drugs such as cyclosporin A, accurate identification of MDR1+/efflux+ AML cases will be critical to identify patients who may benefit from therapies that contain such MDR1 modulators.

Sex differences in estrogen and progesterone receptor messenger ribonucleic acid regulation in the brain of little striped whiptail lizards.

Sex differences in the regulation of steroid hormone receptors in brain areas controlling female- and male-typical sexual behavior may be important in determining sex differences in the display of these behaviors. This study examined sex differences in estrogenic effects on the relative abundance of messenger RNA for estrogen receptor (ER) and progesterone receptor (PR) in discrete brain areas of whiptail lizards, Cnemidophorus inornatus, by in situ hybridization with radiolabeled riboprobes. Gonadectomized females and males received an estradiol benzoate (EB) injection (0.

Chest computed tomography display preferences. Survey of thoracic radiologists.

Rationale And Objectives: The authors conducted a survey of dedicated thoracic radiologists and tabulated their preferences for reconstruction algorithm, display, and photography of computed tomography (CT) scans of the chest.

Methods: Data were derived from a mail survey of 343 active members of the Society of Thoracic Radiology and based on a set of 20 questions about the display and photography of chest CT scans. The response rate was 35.

Pulmonary lymphangitic carcinomatosis: chronicity of radiographic findings in long-term survivors.

Objective: Long-term survival after development of pulmonary lymphangitic carcinomatosis is considered unusual. However, modern chemotherapy can result in surprising stability or only gradual progression of lymphangitic carcinomatosis. We evaluated the course of radiographic findings in 10 patients with chronic lymphangitic carcinomatosis.

Design and conduct of a double-blind, placebo-controlled trial of daunorubicin and cytarabine with or without granulocyte colony-stimulating factor in elderly patients with acute myeloid leukemia: a Southwest Oncology Group study.

From the public health standpoint, acute myeloid leukemia (AML) is an important problem for both young and older adults. AML is the leading cause of cancer death in men aged 15-34 years and the second leading cause of cancer death in women in this age group. This clearly has an impact on loss of life in the productive years.

The implantable pace-maker-cardioverter-defibrillator: radiographic aspects.

Safer and easier placement, recent approval by the U.S. Food and Drug Administration of several models, and increasing availability have expanded the use of implantable cardioverter-defibrillators (ICDs) for treatment of life-threatening ventricular tachyarrhythmia.

Acute aortic dissection: typical and atypical imaging features.

Acute aortic dissection (AAD) is the most common emergency affecting the aorta. Noninvasive imaging allows prompt and reliable diagnosis of AAD and has largely supplanted aortography. However, atypical imaging features and diagnostic pitfalls can delay lifesaving therapy.

Radiographic changes in acute exacerbations of cystic fibrosis in adults: a pilot study.

Objective: We set out to determine whether specific findings can be seen on chest radiographs of adult patients with cystic fibrosis who are having acute exacerbation of respiratory disease.

Materials And Methods: Over a 2-year period, 22 adults with cystic fibrosis had both a baseline chest radiograph and a radiograph obtained either because of acute exacerbation or for some other reason (nonexacerbation). Fourteen radiographic features, including mucous plugs, air-space disease, peribronchial thickening, bronchiectasis, fluid levels, and lymphadenopathy, were scored retrospectively by two radiologists, who did not have knowledge of the patient's clinical condition, as being present, absent, increased, decreased, or unchanged.

ProMACE day 1/MOPP day 8 chemotherapy for prolymphocytic leukemia: a case report of prolonged survival.

The treatment result of a case of de novo B-cell prolymphocytic leukemia (B-PLL) is described. The diagnosis was established with histologic, ultrastructural and immunologic studies. The patient was treated with chemotherapy using a total of seven cycles of ProMACE Day 1/MOPP Day 8 lymphoma regimen.

Medical assessment of bleeding in the surgical patient.

The key to avoidance of hemostatic failure during surgery is to be able to identify the high-risk patient and make a diagnosis and treat the defect before surgery. A thorough history and physical examination are mandatory in this regard. A screening coagulation profile is not a substitute for the history and physical examination.

Predictive respiratory gating: a new method to reduce motion artifacts on CT scans.

Purpose: To evaluate a gating system, called predictive respiratory gating (PRG), that reduces motion-induced artifacts on computed tomographic (CT) scans of patients who cannot suspend respiration.

Materials And Methods: PRG uses a respiration monitor and a new algorithm to predict when a motionless period is about to occur. It automatically starts scanning so the scan is temporally centered around the motionless period at end inspiration or end expiration.

Panlobular pulmonary emphysema caused by i.v. injection of methylphenidate (Ritalin): findings on chest radiographs and CT scans.

Objective: Recent reports have described severe precocious pulmonary emphysema in persons who inject methylphenidate (crushed Ritalin tablets) i.v. We retrospectively evaluated the plain radiographic and CT features in 21 such patients.

Acute myeloid leukaemia in a patient with Seckel syndrome.

We report a female patient with Seckel syndrome who developed acute myeloid leukaemia at the age of 26 years. Analysis of bone marrow chromosomes showed an abnormal clone with abnormalities involving multiple chromosomes, including monosomy 7, trisomy 8, trisomy 11, and loss of the long arm of chromosome 5. After treatment with chemotherapy, the patient experienced severe toxicity with profound bone marrow aplasia and died of pneumonia two months later.

A phase I/II study of sequential interleukin-3 and granulocyte-macrophage colony-stimulating factor in myelodysplastic syndromes.

In this phase I/II study, 9 patients with myelodysplastic syndromes (MDS) were treated with interleukin-3 (IL-3) followed by granulocyte-macrophage colony-stimulating factor (GM-CSF). Each treatment cycle was 28 days long and administered as follows: 1 microgram/kg/d IL-3 on days 1 through 7 and 3 micrograms/kg/d GM-CSF for days 8 through 21, followed by a 7-day rest period. IL-3 dose escalations were planned, but the dose of GM-CSF was fixed.

The geometrical relationship between the human esophagus and left ventricle: implications for three-dimensional ultrasonic scanning.

To establish design parameters for a transesophageal ultrasonic probe to image the left ventricle (LV) in three dimensions, the geometrical relationship between the esophagus and the heart was studied in computed tomographic sections of ten humans. Points describing the esophageal centerpoint and the left-ventricular endocardium were digitized. Algorithms were developed to determine from any esophageal viewpoint the ranges of motion required to cover the LV with four modes of scanning; transverse oblique, longitudinal oblique, rotary and linear.