Publications by authors named "Godse R"
Article Synopsis
- This study investigates the range of skin conditions in patients with germline SUFU pathogenic variants (PVs), focusing on their clinical and histopathologic features.* -
- Conducted across U.S. dermatology and genetics clinics over eight years, the study analyzed skin biopsy samples from five female patients aged 31-68, identifying several types of skin tumors.* -
- Findings reveal that alongside typical basal cell carcinomas, these patients exhibit various indolent skin lesions, indicating a broader range of cutaneous manifestations associated with SUFU PVs.*
Article Synopsis
- Sebaceous carcinoma is a type of skin cancer that's not very common, but it still has about 1,000 cases a year in the U.S., and scientists are trying to find better ways to tell it apart from non-cancerous skin growths.* -
- Researchers studied the DNA and RNA of skin tumors from different hospitals to understand what makes these tumors different and how they develop.* -
- They found specific changes in the tumors that could help doctors diagnose sebaceous carcinoma better, and they believe that new treatments, like using immunotherapy and targeting cholesterol production, might work well.*
Mango, a valued commercial fruit in India is popular mostly because of its attractive flavour. Glycosidically bound volatiles (GBV), an underrepresented warehouse of aroma, remain completely unexplored in Indian mangoes. In this study, GBV were profiled in pulps and peels of 10 Indian mango cultivars, leading to detection of 66 GBV which were dominated by monoterpenoids and phenolics.
View Article and Find Full Text PDFBackground: Testicular germ cell tumor (TGCT) is the most common cancer among young White men. TGCT is highly heritable, although there are no known high-penetrance predisposition genes. CHEK2 is associated with moderate TGCT risk.
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- Histopathologic evaluation of the nail unit is crucial for diagnosing various nail disorders, with recent literature providing updates on different conditions.
- The review covers a variety of nail disorders, including malignancies like melanoma and squamous cell carcinoma, as well as fungal infections and inflammatory conditions.
- Nail clipping histopathology is also highlighted as an increasingly popular and noninvasive diagnostic method for dermatologists and dermatopathologists.
Infantile Digital Fibromatosis/Inclusion Body Fibromatosis: A Comprehensive Literature Review.
Skin Appendage Disord
January 2023
Article Synopsis
- Infantile digital fibromatosis (IDF) is a rare, benign tumor seen in infants and children, usually appearing as a single nodule made up of spindle cells in the skin of the fingers and toes.
- Diagnosis often involves a biopsy, and treatment options generally include observation, corticosteroid injections, or surgical removal of the tumor.
- Due to its rarity, many healthcare providers have limited experience with IDF, prompting a detailed review of its presentation, diagnosis, and treatment methods.
Insulin-derived amyloidosis (AIns) is a rare iatrogenic subtype of cutaneous amyloidosis occurring at frequent insulin injection sites. Here, we describe 2 cases of AIns accompanied by acanthosis nigricans (AN)-like changes, a rare finding which has been reported fewer than 5 times in the literature. We also report the first case of an AIns nodule being misdiagnosed as a keloid.
View Article and Find Full Text PDFUnconventional β-Glucosidases: A Promising Biocatalyst for Industrial Biotechnology.
Appl Biochem Biotechnol
September 2021
β-Glucosidases primarily catalyze removal of terminal glucosyl residues from a variety of glucoconjugates and also perform transglycosylation and reverse hydrolysis. These catalytic properties can be readily exploited for degradation of lignocellulosic biomass as well as for pharmaceutical, food and flavor industries. β-Glucosidases have been either isolated in the native form from the producer organism or recombinantly expressed and gaged for their biochemical properties and substrate specificities.
View Article and Find Full Text PDFImportance: Approximately 50% of the risk for the development of testicular germ cell tumors (TGCTs) is estimated to be heritable, but no mendelian TGCT predisposition genes have yet been identified. It is hypothesized that inherited pathogenic DNA repair gene (DRG) alterations may drive susceptibility to TGCTs.
Objective: To systematically evaluate the enrichment of germline pathogenic variants in the mendelian cancer predisposition DRGs in patients with TGCTs vs healthy controls.
Selegiline hydrochloride (SHCl), a monoamine oxidase B inhibitor, is used as an adjunct in the therapy of Parkinson's disease. This study is concerned with the preparation and evaluation of mucoadhesive buccal tablet for controlled systemic delivery of SHCl. Buccal absorption of selegiline can bypass its first-pass metabolism and improve bioavailability accompanied by greatly reduced metabolite formation, which is potentially of enhanced therapeutic value in patients with Parkinson's disease.
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