Beliefs negatively mediate adolescents' and adults' knowledge about sickle cell disease prevention and relationship choices; a one-center exploratory study in Central Region, Ghana.

Background: Sickle cell disease (SCD) is a common monogenic inheritable condition in sub-Saharan Africa. 30% of Ghanaians are estimated to be carriers creating a condition for stable SCD penetrance. Being inheritable, SCD is scientifically preventable through intentional spousal selection.