Publications by authors named "Godfred Antony Menezes"

Article Synopsis
  • * A 12-year study in the UAE analyzed over 8,000 non-duplicate MTB complex isolates, primarily from respiratory samples, revealing that most patients were non-nationals from Asian countries, particularly India and Pakistan.
  • * The study found low levels of drug resistance, with 2.8% of MTB isolates being rifampicin-resistant and a slight upward trend in resistance observed over the years.
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Mucormycosis is an infrequent but fatal illness that mainly affects patients with uncontrolled diabetes mellitus, diabetic ketoacidosis, solid and hematologic neoplasms, organ transplantation, chronic steroid intake, prolonged neutropenia, iron overload states, neonatal prematurity, severe malnutrition, and HIV. Many cases were reported across the world recently following the COVID-19 pandemic. Recent research has led to a better understanding of the pathogenesis of the disease, and global guidelines are now available for managing this serious infection.

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Article Synopsis
  • * A 12-year surveillance study in the UAE (2010-2021) revealed an upward trend in antimicrobial resistance, with data showing that most cases came from inpatient settings, particularly affecting isolates from urine, blood, and respiratory tracts.
  • * The study found high resistance rates to common antifungals, with notable increases in echinocandin resistance, although mortality rates did not differ significantly between resistant and non-resistant patients.
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Background: Carbapenem-resistant (CRE) are spreading in the United Arab Emirates (UAE) where their dissemination is facilitated by international travel, trade, and tourism. The objective of this study is to describe the longitudinal changes of CRE as reported by the national AMR surveillance system of the UAE.

Methods: In this study, we retrospectively describe CRE isolated from 317 surveillance sites, including 87 hospitals and 230 centers/clinics from 2010 to 2021.

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Introduction: Methicillin resistant (MRSA) is a major contributor to the global burden of antimicrobial resistance (AMR). As MRSA continues to evolve, the need for continued surveillance to evaluate trends remains crucial. This study was carried out to assess MRSA trends in the United Arab Emirates (UAE) based on analysis of data from the national AMR surveillance program.

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Article Synopsis
  • Enterococci typically cause mild infections but can lead to serious diseases like urinary tract infections and meningitis, with rising antibiotic resistance posing significant health threats, especially in the MENA and Gulf regions where data is limited.
  • A 12-year retrospective study analyzed over 37,000 bacterial isolates from the UAE, revealing that Enterococcus faecalis was the most common species found, with 1.8% showing vancomycin resistance (VRE), notably higher in Enterococcus faecium.
  • The presence of VRE is linked to increased patient mortality and longer hospital stays, highlighting the need for more awareness and surveillance of antibiotic resistance in the region.
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Introduction: Although pneumococcal conjugate vaccines (PCV) have been effective in reducing the burden of infections, there is a paucity of data on the relationship with antimicrobial resistance (AMR) trends in the Arabian Gulf region. This study was carried out to assess resistance trends in the United Arab Emirates (UAE) where PCV-13 vaccination was introduced in 2011.

Methods: Retrospective analysis of demographic and microbiological data collected as part of the national AMR surveillance program from 2010 to 2021 was carried out.

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The study was undertaken to determine antioxidant, anticancer and antimicrobial activities of Moringa oleifera flowers. We used three different solvents, hexane (MOF-H), ethyl acetate (MOF-EA) and methanol (MOF-M), to extract the flowers of M. oleifera using the ultrasound-assisted extraction (UAE) approach.

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L. belongs to the family Solanaceae and is distributed throughout the tropical and subtropical regions. leaf and fruit extracts were assessed for in vitro anticancer, antioxidant activity, and total phenolic and flavonoid content.

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Minimally traumatic tooth removal is the norm for removing teeth when a dental implant is planned at that site. The quantity of available bone is the primary requisite to place an implant. The initial use of a scalpel blade to widen the periodontal space followed by the use of luxators is one of the techniques that is being followed for atraumatic extraction.

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Background: Salmonella, a genus of more than 2500 serological variants (serovars), includes many organisms that can cause human disease. Enteric fever remains an important public health problem in developing countries. Non typhoidal Salmonella generally produce a self limited gastroenteritis in healthy individuals whereas in extremes of age and immunocompromised cause severe fatal disease.

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Diamond Blackfan Anemia (DBA) is a rare disorder which presents with anemia in early infancy. This disorder is genetically and clinically heterogeneous in nature. The inheritance is mainly autosomal dominant.

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Background: Leptospirosis is a zoonotic disease with a worldwide distribution. There is a paucity of available data about prevalence of this disease in Pondicherry. Our aim was to investigate the seropositivity rate of leptospirosis in suspected cases and also to identify the predominant serogroups present by performing Microscopic Agglutination Test (MAT).

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Salmonellosis constitutes an important public health problem throughout the world. In severe infections like meningitis and septicemia, antibiotic treatment is essential. Extended-spectrum cephalosporins are preferentially used to treat salmonellosis in children.

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Background: Enteric fever is a major public health problem in India. The current treatment of choice is the fluoroquinolones.

Methods: The minimum inhibitory concentration (MIC) of ciprofloxacin was determined by E-test, HIMEDIA HiComb MIC test and agar dilution.

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