Epithelial-to-mesenchymal transition promotes immune escape by inducing CD70 in non-small cell lung cancer.

Introduction: Epithelial-to-mesenchymal transition (EMT) is associated with tumor aggressiveness, drug resistance, and poor survival in non-small cell lung cancer (NSCLC) and other cancers. The identification of immune-checkpoint ligands (ICPLs) associated with NSCLCs that display a mesenchymal phenotype (mNSCLC) could help to define subgroups of patients who may benefit from treatment strategies using immunotherapy.

Methods: We evaluated ICPL expression in silico in 130 NSCLC cell lines.

[Mammary augmentation surgery and psychology. Clinical reports].

With the clinical observations, the women having request at surgical operations of putting the breast implants, the authors define two groups of requests, by which the women suffered from their breast alterations or hypoplasies. In the different cases the suffering takes the form of identity fault of their feminity. What brings to the reflection on the final definition and formation of the women's identity feelings, the breast implants playing the positive part of reidentification the women's image.

[The therapeutic function of the aesthetic surgery].

By its definition and its etymology, aesthetic surgery is as much a surgery for the soul as for the body. Aesthetic surgery is a true "armed" therapy that essentially targets the psychology of the patient. This therapeutic "arsenal" preserves and/or restores the health of the patient according to its different aspects as defined by the World Health Organization.