Publications by authors named "Go Woon Shin"
Human coronaviruses (HCoVs) modify host proteins to evade the antiviral defense and sustain viral expansion. Here, we report tonicity-responsive enhancer (TonE) binding protein (TonEBP) as a cellular target of HCoVs. TonEBP was cleaved into N-terminal and C-terminal fragments (TonEBP NT and TonEBP CT, respectively) by NSP5 from all the HCoVs tested.
View Article and Find Full Text PDFOne-hit kill: On the inactivation of RNA viruses by ultraviolet (UV)-C-induced genomic damage.
J Photochem Photobiol B
August 2024
Article Synopsis
- Large scale outbreaks of infectious respiratory diseases caused by evolving RNA viruses are becoming more severe and harder to control with current vaccines and treatments.
- Germicidal UV-C is an effective disinfection method that can inactivate RNA viruses, and its effectiveness has been linked to genomic damage in the viruses.
- This study finds that larger genomic damage correlates with increased inactivation of RNA viruses, suggesting even minimal damage can suffice to render them inactive.