Publications by authors named "Go Endo"
Article Synopsis
- The study investigates the effects of homologous recombination deficiency (HRD) on time-to-treatment failure (TTF) in patients with unresectable and recurrent pancreatic cancer (PC) receiving first-line chemotherapy.
- Among 1,394 patients analyzed, HRD was identified in 7.6% through genetic testing, with commonly affected genes being BRCA2 and ATM.
- Results showed no significant TTF difference in the gemcitabine plus nab-paclitaxel (GnP) group; however, in the FOLFIRINOX (FFX) group, HRD patients had a significantly longer TTF compared to non-HRD patients, suggesting HRD may influence treatment outcomes in certain chemotherapy regimens
Article Synopsis
- The study evaluated the use of endoscopic ultrasound-guided tissue acquisition (EUS-TA) with a 22-gauge Franseen needle for collecting tissue samples from solid tumors, focusing on its application in comprehensive genomic profiling (CGP) tests, especially for pancreatobiliary cancer.
- A total of 50 patients were analyzed, showing that the success rates for obtaining suitable samples for CGP were 86% and 76% through two quality control checks, with an adverse event rate of 4%.
- The findings indicated that while EUS-TA using this method is feasible, a significant portion of the specimens did not meet CGP criteria, raising questions about sample adequacy for genomic analysis despite successful tests.
Article Synopsis
- A 67-year-old female undergoing chemotherapy for pancreatic cancer developed bacteremia caused by Kluyvera georgiana after surgery.
- Diagnosis was confirmed using advanced mass spectrometry techniques.
- Literature suggests that infections by Kluyvera spp. are linked to immunosuppression and may show antibiotic resistance, stressing the need for early diagnosis and treatment.
Article Synopsis
- Sarcopenia, the loss of skeletal muscle mass and function, affects survival rates in patients with biliary tract cancer, but its impact on overall survival is less clear.
- A study of 386 patients used CT scans to measure skeletal muscle index (SMI) and skeletal muscle density (SMD) and found that patients with sarcopenia had shorter progression-free survival (PFS).
- The research suggests that monitoring and improving muscular quantity and quality could be beneficial, emphasizing the need for nutritional and physical interventions in these patients.
Article Synopsis
- A study examined the safety and effectiveness of placing a second endoscopic self-expandable metal stent (SEMS) for patients with recurrent malignant gastric outlet obstruction (GOO), involving 95 cases from April 2006 to December 2022.* -
- Both covered (cSEMS) and uncovered (uSEMS) SEMS showed similar high rates of technical and clinical success, adverse events, and overall survival, with no significant differences in stent effectiveness over time.* -
- The study found that chemotherapy after second SEMS placement improved the time to recurrent GOO, suggesting the type of SEMS might be selected based on why the first one failed.*
Article Synopsis
- The study investigated changes in blood markers and morphological features in patients with intraductal papillary mucinous neoplasms (IPMNs) who later developed pancreatic cancer.
- Out of 3437 IPMN patients, 100 developed pancreatic carcinomas, with findings showing that CA19-9 elevation was more common in concomitant carcinomas compared to IPMN-derived ones.
- The research concluded that while some morphological features indicated risk for IPMN-derived carcinomas, blood biomarkers had limited effectiveness in early cancer detection related to IPMNs.
Article Synopsis
- - The study examines the efficacy of endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) for diagnosing solid pancreatic lesions, particularly focusing on the impact of biliary stents in patients with obstructive jaundice.
- - Results showed that EUS-FNA accuracy and sensitivity were significantly lower in patients with biliary stents compared to those without, indicating that the presence of stents hampers diagnostic effectiveness.
- - The findings suggest that EUS-FNA should ideally be performed before endoscopic retrograde cholangiopancreatography with biliary stent placement in cases of obstructive jaundice to improve diagnostic outcomes.
Objectives: Endoscopic management of unresectable hilar malignant biliary obstruction (HMBO) is technically challenging, and effectiveness of stent-in-stent using large-cell, metal stents was reported. A new, large-cell stent with a 6F tapered delivery system was recently developed. The aim of this study was to compare clinical outcomes of slim-delivery and conventional large-cell stents.
View Article and Find Full Text PDFThe Illumina MiSeq platform has been widely used as a standard method for studying the rumen microbiota. However, the low resolution of taxonomic identification is the only disadvantage of MiSeq amplicon sequencing, as it targets a part of the 16S rRNA gene. In the present study, we performed three experiments to establish a high-resolution and high-throughput rumen microbial profiling approach using a combination of MinION platform and buccal swab sample, which is a proxy for rumen contents.
View Article and Find Full Text PDFWe herein report a case of gastrointestinal (GI) Kaposi's sarcoma (KS) without cutaneous involvement in a 73-year-old man who had received immunosuppressive drugs for granulomatosis with polyangiitis. After one year of prednisolone use, he presented with tarry stool and severe anemia. Endoscopic and pathological examinations revealed bright-reddish protruding lesions with proliferating spindle cells positive for D2-40, CD34, and HHV-8, which are definitively diagnostic of GI-KS.
View Article and Find Full Text PDFBrugada syndrome is an arrhythmogenetic disease characterized by electrocardiographic ST segment elevation in right precordial leads, which is called "coved type", and an increased risk of sudden death as the result of ventricular fibrillation. We presented a case of Brugada syndrome with a convulsive seizure, during administration of a tricyclic antidepressant for the treatment of a depressive state. A 43-year-old man with bipolar II disorder and obsessive-compulsive disorder was admitted to our hospital for the treatment of a depressive state.
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