[The protective role of postvaccinal immunity in mumps in children].

The immunological study of children with infectious parotitis (IP) without complications and with such complications as pancreatitis, meningitis or orchitis in the glandular form was carried out. In accordance with the previously proposed principle, 4 types of immune response (IR) were established on the basis of differences in initial resistance and the IR profile: cell-mediated immunity (types I and III) and humoral immunity (types II and IV). The patients included nonvaccinated children, as well as children vaccinated on epidemic indications, 3-6, 7-9, 10 and more years before infection.

[Variants of immune response in children with acute respiratory viral infections].

Four patterns of changes in the proliferative activity of T-lymphocytes in the lymphocyte blastogenesis test with phytohemagglutinin (PHA) are distinguished in children with acute respiratory viral infections (ARVI). The differences between these patterns are due to aggravated clinical severity of the infection process and enhancement of the cytokine reaction of macrophage monocytes. Comparison of immunological characteristics of response to ARVI in 4 groups of children showed that high reactivity of T-lymphocytes during the acute phase of disease (first and third variants) correlated with a relatively weak production of immunoglobulins and antiviral antibodies, while the suppression of T-lymphocyte response to PHA (second and fourth variants) is associated with expressed humoral profile of immune response by the level of immunoglobulin and antiviral antibody production.

[Variants of the immune response in the dynamics of the localized form of stomatopharyngeal diphtheria in children].

4 variants of immune response (IR) have been identified according to the dynamics of the development of nonspecific immunosuppression as determined in the reaction of lymphocyte blast transformation to phytohemagglutinin. These variants, characterized by a rise in the production of tumor necrosis factor alpha, interleukin 1 beta, immunoglobulins of 4 classes, are linked with the increased risk of the development of clinically pronounced forms (CPF) of diphtheria. The antigen-specific profile of each of these variants (types) of IR has been studied.

[The effect of specific trophoblastic beta 1-glycoprotein on changes in the cellular link of immunity in infected abortion].

Effects of specific trophoblastic beta-1-glycoprotein (TBG) on T- and B-cell immunity have been explored in 107 patients with purulent septic complications of abortion. TBG showed a marked suppressor effect on T lymphocytes. Persistence of TBG in blood of patients with infection complicated abortion maintains immunodeficient states.

[A method of studying the initial regulatory activity of blood cells in lymphocyte transformation reaction].

The authors suggest a simple method for studying the lymphocyte blastogenesis (LBG) regulation in whole blood culture, consisting in preincubation of a part of the material and comparison of the results in two variants of the experiment: upon immediate mitogen stimulation and stimulated in 24 hrs after pre-cultivation. LBG activation or suppression is established from the value of the preincubation index.

[Nonspecific protection and specific immunity in various clinical forms of mumps virus infection in children].

The time course of specific antibody production, interferon production in the blood and cerebrospinal fluid, and the capacity of blood cells for interferon production were compared in 270 children with glandular and neuroglandular forms of mumps virus infection (MVI). A significant decrease of antibody production in neuroglandular form of MVI and lower interferon titres in the blood in the acute period of this form of infection were noted. The severity of the course of meningitis was inversely related to interferon levels in the cerebrospinal fluid of the patients.

[Effect of a number of preparations on the function of the immune system in experimental influenza in mice].

(CBA X C57B1) X F1 mice were sensitized intraperitoneally with sheep erythrocytes and infected with influenza A viruses: nonpathogenic Leningrad-77 (H1N1) or pathogenic PR8 (HON1), before or five days after administration into the oesophagus of sodium succinate, levamisole, complexes I (panangin, sodium succinate, sodium glutamate) and 2 (lipoic acid, phosphothyamine, riboflavin, sodium pantothenate). The number of rosette-forming cells (RFC) in the spleen at 7 and 14 days postinfection, antibody titres, interferon level in the blood, the amount of virus in the lungs, spleen and lung morphology were studied. All the preparations used were found to increase the number of RFC in the spleen.

[Chromosomal aberrations induced by thio-TEPA in cells of malignant ovarian tumors in humans].

Chromosome abberations in cells of 4 ovarian cancer patients have been studied prior to and during the treatment with ThioTEPA. ThioTEPA was injected intraperitoneally once a week in a dose of 40 mg. The amount of abberant cells prior to the therapy averaged 7.