Polymorphic variants of the hOGG1, APEX1, XPD, SOD2, and CAT genes involved in DNA repair processes and antioxidant defense and their association with breast cancer risk.

Breast cancer is one of the leading causes of mortality among women. The most frequently encountered tumors are luminal tumors. Associations of polymorphisms in the hOGG1 (rs1052133), APEX1 (rs1130409), XPD (rs13181), SOD2 (rs4880), and CAT (rs1001179) genes were studied in 313 nonsmoking postmenopausal patients with luminal B subtype breast cancer.

[A multidisciplinary approach in the treatment of elderly and senile patients with complications of colon cancer.].

The article presents the results of treatment of elderly and senile patients with complications of colon cancer, in whose perioperative management a multidisciplinary approach was used. The peculiarity of patients in older age groups, caused by polymorbidity, the phenomenon of mutual complication, requires the use of a non-standard approach in the treatment of complicated colon cancer, since the latter is accompanied by negative results. A comparative analysis of the results of treatment of 289 elderly and senile patients with complicated colon cancer by the traditional method and using a multidisciplinary approach was carried out.

[Endoscopic treatment of choledocholithiasis in patients over 80 years old].

Objective: To analyze endoscopic treatment of choledocholithiasis in patients over 80 years old.

Material And Methods: A single-center retrospective study included 90 consecutive patients aged ≥80 years and 58 patients aged 60-79 years. Early outcomes including efficacy of calculus removal, incidence of complications and their risk factors were evaluated.

[Improvement of diagnostics and tactics of treatment of patients of elderly and senile age with acute obturational pulpositional obstacle of tumor genesis.].

The results of providing care to 346 elderly and senile patients with acute obstructive intestinal obstruction of tumor Genesis were analyzed. In the diagnosis of acute intestinal obstruction, along with traditional diagnostic methods, the dynamics of intra-abdominal pressure and hemodynamic parameters in the visceral arteries of the abdominal aorta were evaluated. Based on the study, it was shown that acute obstructive intestinal obstruction is accompanied by an increase in intra-abdominal pressure and a reduction in blood flow in the visceral arteries of the abdominal aorta.

[Are hybrid technologies appropriate for revascularization of aortoiliac-femoral segment?].

Objective: To compare various approaches to revascularization of aortoiliac-femoral segment.

Material And Methods: Data were collected prospectively for retrospective analysis. There were 192 patients with atherosclerotic lesion of the aortoiliac-femoral segment who underwent reconstructive surgeries.

[Immediate results of surgical treatment of complicated colorectal cancer in elderly and senile patients.].

The work analyzes the results of surgical treatment of 545 elderly and senile patients with complicated forms of colon cancer. Among colon cancer complications frequently encountered acute intestinal obstruction (AIO) - 413 (75,8%), less likely to have been identified - perifocal inflammation (PPV) with abscess - 80 (14,7%), bleeding - 30 (5,5 %) and tumor perforation - 22 (4%). Operations on the colon were performed as a traditional method - 408 (74,9%) and with the use of endovideosurgical technologies - 137 (25,1%).

[Choice of the revascularization method for patients of elderly age with infraeinguvinal arterial disease.].

The aim of the study was to perform a comparative evaluation of the use of various methods of reconstructive assistance in the defeat of the femoral-tibial segment in elderly patients with peripheral arterial disease. 253 patients over 60 years old (60-74 years and more than 75 years) with atherosclerotic lesions of arteries below the inguinal ligament were examined and revascularized. According to the type of reconstruction performed, the patients were divided into 3 groups: 98 patients underwent open surgical interventions; 116 patients underwent endovascular interventions; 39 people performed hybrid reconstructions.

TREATMENT OF PATIENTS WITH COMPLICATIONS OF COLON CANCER IN CONDITIONS OF MULTIFIELD GERONTOLOGICAL HOSPITAL.

The article analyzes treatment results of 482 patients of elderly and senile age with complicated colon cancer forms who were in the hospital for war veterans at the period from 2008 to 2014. The more frequent complication of colon cancer was an acute intestinal obstruction (76,8%). Peritumorous inflammation with abscess formation was noted in 13,5% cases, hemorrhage - in 5,6% tumor perforation - in 4,1% cases.

[THE CHOICE OF SURGICAL TREATMENT OF OBSTRUCTIVE ILEUS IN ELDERLY AND SENILE PATIENTS].

The article presents results of treatment of 100 patients with elderly colon cancer complicated by obstructive ileus. Patients were divided into two groups of 50 people. Main group patients for colon surgery performed using laparoscopic techniques.

An energy transfer kinetic probe for OH-quenchers in the Nd(3+):YPO4 nanocrystals suitable for imaging in the biological tissue transparency window.

Tetragonal xenotime-type yttrium orthophosphate (YPO4) Nd(3+) doped nanoparticles suitable for biomedical applications were prepared by microwave-hydrothermal treatment. We applied the energy transfer probing based on the analysis of kinetics of impurity quenching to determine the presence and spatial position of -OH fluorescence quenching acceptors in the impurity-containing nanoparticles. We show that the impurity quenching kinetics of the 0.

[Improvement in the diagnosis, therapy, and prevention of complications in patients with rectal cancer].

The goal of this study was to assess the informative yield of modem radiology diagnostic (endorectal and intraoperative sonography, spiral computed tomography and magnetic resonance imaging) and three-dimensional modeling methods in patients with rectal cancer. The effectiveness of postoperative immune-modulating therapy (Neovir and Betaleukin) was also evaluated. The aforementioned techniques contributed to an adequate preoperative selection of surgical treatment and allowed reducing the incidence of postoperative complications.

[Resources of modern methods of radiodiagnostics in optimization of surgical treatment of patients with rectum cancer].

An investigation of the information value of modern radial methods of diagnostics (endorectal and intraoperative sonography, spiral computed and magnetic resonance imaging) and Power Shape program for three- dimensional modeling in 150 patients with rectum cancer has shown their significance in the assessment of prevalence of the tumor process, invasion of the tumor into the rectum wall, its spreading in the intestinal wall, involvement in the tumor process of the pararectal fat and adjacent to the rectum organs of the small pelvis, the presence of signs of metastases to the regional lymph nodes. These methods of X-ray analyses and three- dimensional computed modeling of the tumor process of the rectum facilitate preoperative decision on the adequate volume of surgery.

[Possibilities of ultrasonography in diagnostics and treatment of nonparasitic cysts and abscesses of the liver].

The results of ultrasound diagnostics of focal fluid lesions of the liver in 132 patients are presented. Echographic semiotics of abscesses and nonparasitic cycts of the liver is described. The possibilities of using transcutaneous minimally invasive puncture and drainage methods in 80 patients under ultrasound control were analyzed.

[Intermittent pneumatic compression of the lower extremity muscles in complex prophylactics of postoperative venous thromboses in elderly and senile patients].

An analysis of frequency of venous thrombitic complications after different operations on 69 patients aged from 69 through 87 was made. The greatest number of venous thromboses was noted after amputations of the femur. Intermittent pneumatic compression of the lower extremities in addition to standard methods of prophylactics reduced the number of postoperative thromboses from 12.

[Disturbances of bone tissue metabolism in elderly and senile patients after stomach resection].

The authors have examined 104 elderly patients after one of operations on the stomach. The mineral metabolism, biochemical and X-ray findings were investigated. Osteoporosis was observed more often in patients after Billroth-II resection of the stomach, rarer after Billroth-I operation and more rarely in patients after pylorus-saving resection of the stomach.

[Intraductal photo-irradiation of bile in complex treatment of patients with cholangitis].

The authors have analyzed results of complex treatment of cholangitis patients by the application of intraductal photoirradiation. This method of treatment was shown to give more favorable course of the postoperative period.

[Results of minilaparotomies in treatment of cholelithiasis in elderly and senile patients].

The authors have analyzed results of surgical treatment of 79 patients with cholelithiasis using a mini-access. The method can be widely used in patients with high operative risk. It is minimally traumatic, has less lethality and a fewer number of early and late postoperative complications.

[The efficacy of Neovir in the combined treatment of patients with operable tumors of the gastrointestinal tract].

Under observation there were 32 patients with operable tumors of the gastro-intestinal tract. The average age of the patients was (64.8 +/- 7.

[The surgical procedure in sigmoid obstruction].

The authors report on operations on 280 patients for diseases of the sigmoid colon (106 patients with acute ileus included). Results of different operations and the technique of the exclusion of the dolichosigmoid are described.