Immunofluorescence diagnosis of the herpesvirus stillborn infection.

Congenital herpes infection belongs to the category of actual problems of Perinatal Medicine. Pathological diagnosis of this disease is not effective in the routine method of autopsy studies without virological research. Objective.

[The clinical value and methodological bases of a gross study of neonatal placentas].

A two-step study of placentas is proposed if departments of morbid anatomy have none or limited feasibility. A gross study of the organ's constituents is conducted by neonatologists at maternal hospitals in the first step and in a specialized department of morbid anatomy in the second one. Placental manipulations are differentiated between the neonatologists and pathologists.

[Introduction into fetal nosology].

The urgent social and medical problems of intrauterine death of alive fetuses require that pathomorphological studies of the fetoplacental complex be improved to diagnose major fetal abnormalities. It is proposed to refuse the universal diagnosis of symptomatic intrauterine hypoxia and to shift to its nosological diagnosis. Particular emphasis should be placed on the detection of placental-umbilical and cardiovascular pathology and hematogenic, hemorrhagic, and other fetal diseases.

[Fetal compensatory and abnormal reactions in fetoplacental insufficiency].

The review of the data available in the literature traces the pathogenetic association of chronic fetoplacental insufficiency (CFPI) with the mechanisms responsible for cardioplacental circulation, hypoxic encephalopathy, and neonatal respiratory distress syndrome. Infectious abnormalities of the fetal membranes, placenta, and umbilical cord are of combined pathogenic importance in cases of CFPI.

[Pathogenetic features of respiratory distress syndrome in newborns with extremely low body weight].

Congenital atelectasis and ascending infection around the fetuses were of importance in the pathogenesis of respiratory disturbances in 38 newborns with extremely low body weight.

[Some problems of anatomopathological diagnosis in perinatology].

The authors discuss the problems of adequate documentation of autopsy diagnosis in death of fetuses and newborns and relations to ICD-10. It is suggested to legitimize and perfect the structure of diagnosis in perinatology.

[Pathogenetic basis of hormonal endometrial hypertrophy in early spontaneous abortions].

Pathogenetic role of hormonal dissociation produced by disturbances of biochemical transformation of testosteron to estradiol in the mechanism of deficient gestational endometrial transformation is shown.

[Pathomorphological and hormonal criteria in the diagnosis of causes of spontaneous abortions].

The authors think it necessary to research causes of each case of spontaneous abortion more thoroughly. Pathomorphological manifestations of chromosomal, endocrine, immune and infectious pathology of the fetal bubble and endometrium are described. These criteria are compared to then content of sex steroid hormones in the circulating blood of pregnant women.

[Pathogenic basis of intrauterine infections].

The literature and the authors' own results on pathogenesis of intrauterine infections are reviewed. Special attention is paid to the mechanisms of contamination, disease stages and cellular-humoral responses of the fetus. Implications of the above factors in the formation of multiple clinicomorphological manifestations of the intrauterine infections are pointed out.

[The morphological manifestations of hormonally induced changes in the fallopian tubes].

The author's and literature data on the alterations in the visually normal uterine tubes removed in the course of the uterine body and adnexa amputation are presented. The practical importance of the study of uterine tubes in the indirect assessment of the hormonal background and individual pathogenesis of some gynecological diseases is noted.

[Organizational-methodological basis and first results of the work at the Leningrad Pathology Bureau].

The program of the reorganization of Leningrad pathology service is presented. Particular emphasis is laid on the permanent professional control of the pathologists activity and medico-social necessity of a systematic detailed analysis of prosector's work.

[Necessity of autopsies of patients dying at home].

Half of death certificates issued by the outpatient departments provide wrong information on the cause of death. The suggestion in made on the necessity of autopsies of patients dying at home.

[Characteristics of the hormonal-immunologic status in inflammatory disorders of the female reproductive system].

The presence of cooperative hormonal-immunologic reactions in the female reproductive tract is substantiated. The features of their regional morphologic manifestations in menarche, hormonal pregnancy and non-complicated delivery are described. The importance of specific hormonal factors in the pathogenesis of ascending genital infections at various stages of the gestational period is shown.

[Morphological appearance of cellular immune reaction in the endometrium in spontaneous miscarriage].

Morphometric analysis of lymphocyte, macrophage and polymorphonuclear leukocyte levels in the endometrial stroma was performed in 67 spontaneous and 30 induced abortions during 5-12 weeks of gestation. The results were correlated with the degree of structural maturity of decidual tissue and terminal chorionic villi and showed activation of lymphocyte macrophage reaction mostly pronounced in case of incomplete decidual transformation of endometrial stroma and hypoplastic alterations of chorionic villi. It was concluded that the aforementioned changes were secondary to a decreased function the gravid yellow body and subsequent activation of cell-mediated immune response in the endometrium during spontaneous abortion.

[Drainage of the uterine cavity in postpartum endometritis].

Analyzes the results of management of protracted torpid postpartum endometritis (10 cases) and severe septic endometritis following a cesarean section (9 cases), multiple-modality treatment of these patients including prolonged influent-aspiration drainage of the uterine cavity. Describes the drainage system, its fixation, and operation. Discusses a differentiated approach to infusion of the drugs directly into the uterine cavity in cases with the uterine inflammations.

[Intracranial oncogenic aneurysm].

The paper deals with a death from cerebrosubarachnoidal hemorrhage in a 22-year-old male. Autopsy revealed fusiform aneurysm at the junction of right posterior connective and cerebral arteries whose wall was histologically examined. The examination indicated that the wall was invaded by tumor cells from the endothelium, the internal elastic membrane and vascular muscle layer being destructed.

[Latent intracranial tumors as a cause of sudden death].

An analysis of the clinico-morphological data on 8 cases of undiagnosed intracranial tumors showed these neoplasms to be the cause of sudden death as a result of cerebral circulation disorders or an acute swelling of the brain.