[Orthodontic treatment of adult patients with mandibular retrognathia].

This article describes a case report of the patient with mandibular retrognathia, class II malocclusion, constriction and deformation of dental arches and bimaxillary protrusion. Due to the patient's refuse to undergo the orthognathic surgery, after diagnostic, it was decided to carry out the orthodontic dentoalveolar compensation. The combined use of the functional fixed telescopic appliance (FFTA), bracket system and orthodontic miniscrews made it possible to effectively normalize the mandibular position, achieve orthognathic occlusion, eliminate bimaxillary protrusion and improve the face profile.

[Objective and subjective assessment of the quality and effectiveness of orthodontic treatment].

Dentofacial anomalies occupy one of the leading places among dental diseases in people of different age groups. Analysis of epidemiological data on the prevalence of dentoalveolar anomalies indicates that there is no tendency to decrease it in Russia and abroad countries. The demand for orthodontic treatment is increasing with the development of new technologies and materials, the development of modern methods of treatment in the field of dentistry.

[Assessment of dental arches expansion using ligature and passive self-ligating braces in combination with Pitts broad arches and early elastics].

The Aim Of The Study: Was to analyze the effectiveness of the use of Pitts Broad and early elastics in the treatment of patients with narrowing and deformation in dentition.

Materials And Methods: The results of orthodontic treatment of 46 adult patients with narrowing and deformation in dentition are presented. Patients were separated in 2 groups, depending on the algorithm of treatment: group 1 - using the braces of passive self-ligation, Pitts Broad and early short elastics; group 2 - using ligature braces and archwires Orthos.

[The experimental study of a Russian orthodontic mini-screw].

Background: The aim of this research is the experimental study measuring stability of the orthodontic miniscrews «Turbo» designed in Russia in comparison with its foreign analogues, namely, «Vector Tas» (USA) and «BioRay» (Taiwan).

Material And Methods: Four self-drilling orthodontic miniscrews of each manufacturer, i.e.

[Algorithm for treatment of patients with class II malocclusion rejecting orthognathic surgery].

Unlabelled: The of this study is to develop algorithms for the treatment of patients with class II malocclusion and incisor protrusion using the combination of bracket system, functional fixed telescopic appliance (FFTA) and skeletal anchorage, which allows to achieve effective dentoalveolar compensation of skeletal forms of class II malocclusion.

Materials And Methods: Orthodontic treatment of 60 patients with class II malocclusion at the age of 18 to 44 years, using the bracket system, FFTA and orthodontic miniscrews was performed. In order to assess the results of treatment, cone-beam computed tomography were obtained at the beginning and at the end of treatment.

[EMPIRICAL ANTIBACTERIAL PROPHYLAXIS IN EMERGENCY SURGERY].

The main principles of selecting antibacterial drugs for prophylactic therapy of patients prior to surgery of gastrointestinal tract, vessels, skin, and soft tissues are considered. Special attention is devoted to antibacterial prophylaxis in co-morbid patients, in particular those with chronic renal insufficiency, chronic liver disorder, decompensated diabetes mellitus, and allergy to beta-lactam antibiotics. All proposed schemes are optimized with respect to three criteria: clinical effectiveness, economic feasibility, and epidemiologic safety (stopping the selection of poly-resistant microbial families).

[The role of fast and slow potassium currents in electrical activity of amphibian myelinated nerve fibres].

The paper reviews the information about the role of fast and slow potassium currents in electrical activity of amphibian myelinated nerve fibres. It demonstrates the importance of discovering of fast and slow potassium currents and their following pharmacological separation (by potassium channels blockers 4-aminopyridine and tetraethylammonium) in investigation of mechanisms of biological potentials generation. The information about the existence of fast and slow potassium channels in the nerve membrane and about the properties of 4-aminopyridine and tetraethylammonium action served as a base for determination the nature of biological potentials and discovering the mechanism of potential-dependent action of 4-aminopyridine that for tens of years suffered from the lack of adequate explanation.

[Prolonged after-potentials of the myelinated nervous fibres in amphibia after 4-aminopyridine-induced blockage of potassium channels].

Myelinated nerve fibres of Rana ridibunda Pallas were studied by using extra-cellular recording technique. 4-aminopyridine, a blocker of fast potassium channels produced considerable changes in duration of the after-depolarization and increase in total membrane depolarization (evaluated by an action potential area). These effects were time-dependent.

[Use of a laryngeal mask during combined regional anesthesia in children].

For intraoperative anesthesia, the authors applied central regional blocks. A laryngeal mask was used to maintain free airways patency. The purpose of this study was to provide evidence for the effectiveness of a laryngeal mask used under combined regional anesthesia and to establish whether the mask could be employed for artificial ventilation during laparoscopy in children.

[Transformation of electrical activity in the myelinated nerve fibres of amphibia by 4-aminopyridine].

Using the extracellular recording we studied the effect of 4-aminopyridine (4-AP), a potassium channel blocker on the electrical activity of the myelinated nerve fibres of amphibia Rana ridibunda Pallas. Two main types of the reaction on 4-AP were established: extension of the action potential and multi-spike response. In some cases the nerve fibres with multi-spike response generated spontaneous activity without stimulation in the form of bursts of action potentials.

[Analytical biotechnology of recombinant peptides and proteins. II. Primary structure of the fusion protein containing human proinsulin and optimization of its proteolysis by trypsin].

The kinetics of trypsin proteolysis of the fusion protein (FP) containing human proinsulin was studied by a set of analytical micromethods. These were the microcolumn reversed-phase HPLC and the qualitative identification by MALDI-TOF mass spectrometry and amino acid sequencing. The first stage of the proteolysis was shown to be the cleavage of FP into the leader fragment and proinsulin.

[Study of the action of immunomodulator T-activin on electric properties of plasma membranes of thymus cells by the use of fluorescent probes].

T-activin alters the electric properties of plasmatic membranes of the T-activin treated suspension of mouse (CBAX X057B1) F1 thymic cells. These alterations were registered by means of negative charged fluorescent probe l-anilino-naphthalene-8-sulfonate (ANS) and positive charged 4-(p-dimethylaminostyryl)-1-methylpyridinium (DSM) by measurement of their fluorescence in the individual thymic cell. Apparently, T-activin leads to depolarization of transmembrane potential on plasmatic membrane of thymic cells.

[Postactivational changes in the reflex excitability of the motoneuronal apparatus of the spinal cord in newborn infants].

In 16 newborn infants ageing from several hours to 6 days, by means of paired stimulation, studies have been made on postactivational recovery of the reflex excitability of spinal motoneuronal apparatus. It was shown that early phases of the recovery cycle (early facilitation and depression) are similar in all the infants studied and do not significantly alter with age, whereas later phases within the first days of life follow two types. The first type is characterized by the intensive secondary facilitation which is transformed into exaltation, late depression being absent.