[Comparative economic and clinical effectiveness of setegis and camiren in therapy of chronic prostatitis].

The drugs setegis 2 mg, camiren 2 mg, were used in the investigation designed to study economic and clinical effectiveness of employment of alpha-blockers for treating chronic prostatitis, with the expediency of the above therapeutic modality having been corraborated by the findings secured. Objective control of the treatments administered necessitates studying the time-related changes in indices for the amount of the residual urine and volume of the prostate. Economic expediency has been shown of use of camiren 2 mg, an alpha-blocker, of the KRKA firm, which fact was validated by a lower cost of the drug at the retail market of Ukraine compared to setegis 2 mg.

[Modeling of pemphigus vulgaris in guinea pigs].

In 146 guinea pigs with body weight of 150-200 g pemphigus vulgaris (PV) was induced using screening techniques. The animals were injected with PV patients' IgG (IgGPV) and blister fluid (PVBF) with the PV patient mononuclears. Intraperitoneal administration of IgGPV caused dystrophy in epidermis of experimental animals while intracutaneous injection of PVBF resulted in balloon dystrophy.

[The pathophysiological disorders and experimental therapy in pemphigus and pemphigoid].

Guinea pig experiments (n = 196) with simulation of pemphigus vulgaris and bullous pemphigoid helped detect pathophysiologic and metabolic disorders similar for these autoimmune bullous dermatoses: decompensated endoproteinase-inhibitor system, impaired ratio of cyclic nucleotide to arachidonic acid oxigenase metabolism products concentrations in the blood of experimental animals. The key point in the treatment of animals with pemphigus vulgaris was endogenic proteinase inhibition, that in the treatment of bullous pemphigoid--blocking of mononuclear macrophagal histolytic potential.

[The ultrastructural changes in the clinically unaffected skin of patients with pemphigus vulgaris].

Analysis of the results of light optic, immunofluorescent, and electron microscopic studies of biopsy specimens of intact skin of forearms and of the skin adjacent to lesions in 10 patients with untreated pemphigus vulgaris has lead the authors to a conclusion on the uniform pattern of ultrastructural changes in all sites of the epidermis in pemphigus patients. A combination of the signs of involvement of prickle and basal-cell structures (desmosomes and mitochondria) and of signs of cellular metabolic activation (euchromatism, active status of the nucleolus) anticipate the development of intra- and extracellular changes in pemphigus.

[Clinical forms of atopic neurodermatitis].

Basing on their own observations and analysis of data on the clinical picture and pathogenesis of atopic dermatitis, the authors suggest that four clinical forms of this condition be distinguished: erythematous squamous, erythematous squamous with lichen transformation, lichenoid, and prurigo-like. They consider it advisable that such terms as catarrhal exudative diathesis, childhood eczema, and diffuse neurodermatitis be used no more. Itching is suggested to be considered as a symptom and not cause of itching dermatoses.

[The role of kallikrein-kinin system components in the pathogenesis of bullous skin lesions in pemphigus and pemphigoid].

Importance of kallikreinogenases in acantholysis and epidermo-dermal separation was shown, when the kallikreinkinin patterns were studied in blood plasma and blister fluids of 118 patients with pemphigus, of 78 patients with pemphigoid as well as of 224 guinea pigs. Under conditions of pemphigoid, as distinct from pemphigus, serine proteinases were mainly produced by active immunocytes responsible for destruction of epidermal basement membrane; activation of kinins was observed in skin impairments.

[The results of phylogenetic and experimental research into the etiology of pemphigus vulgaris].

An antigen, binding with antibodies from patients with pemphigus vulgaris, has been found in the epidermis of a shedding Natrix natrix. This permitted a hypothesis on the atavistic nature of pemphigus, consisting in the following: abolition of tolerance to pemphigus antigen (PA) in humans and mammals is explained by the release of the 'shedding' atavistic gene, that codes for the humoral factor responsible for PA expression in keratinocytes. This hypothesis has been confirmed by experimental induction of pemphigus-like changes of the serpentine and murine epidermis (by subcutaneous injections of a shedding snake serum protein--SSSP), as well as by experiments with SSSP blocking of pemphigus induced by passive transfer of antibodies from patients with pemphigus vulgaris to newborn BALB/s mice.