Stakeholder engagement to increase the impact of water technology case studies.

Successful uptake and acceptance of technologies and strategies for symbiotic solutions require active engagement of relevant stakeholder groups. By exchanging knowledge, developing ideas, and learning together, stakeholders contribute to innovative and sustainable water management solutions within industrial symbiosis. ULTIMATE fosters such engagement across its nine case studies (CS) through three approaches: eXtended Reality technologies for Immersive Media Experiences (IMX), Communities of Practice (CoPs), and Water-Oriented Living Labs (WOLLs).

Role of surgery in the management of postmastectomy extremity angiosarcoma (Stewart-Treves syndrome).

Stewart-Treves syndrome (STS) is the rare occurrence of angiosarcoma in a setting of postmastectomy upper extremity lymphedema. A collective comparison of outcomes following various initial treatment options in STS has not previously been reported. We reviewed 160 cases of STS reported in the literature since 1966.

Carbon dioxide laser repair of medial ectropion.

Five patients with medial eyelid ectropion and punctal eversion due to senile changes, cicatrix, or vertical skin tightness were treated with a heretofore unreported method. Using a carbon dioxide laser, an ellipse of conjunctival-tarsal-inferior muscle tissue was excised from the inner surface of the ectropic lid inferior to the punctum. There was no bleeding, and each postoperative course was notable for minimal pain and edema.

Amitriptyline normalizes tetrabenazine-induced changes in cerebral microcirculation.

The cerebromicrocirculation in the tetrabenzaine (TBZ) model of depression has been found to be abnormal with respect to (1) responsiveness of cerebral blood flow to increases in arterial CO2 content and (2) the effective permeability of the blood-brain barrier to water. Development of these abnormalities temporally paralleled the behavioral disturbances and catecholamine depletion induced by TBZ. These TBZ-induced changes occurred globally throughout the brain, being apparent in the forebrain, cerebellum, and medulla-pons.

Prognostic factors in colorectal carcinomas arising in adenomas: implications for lesions removed by endoscopic polypectomy.

Endoscopic polypectomy has become the preferred technique for the removal of most colorectal adenomas. Whether polypectomy alone or segmental colectomy is the appropriate management of the patient whose adenoma contains carcinoma is a controversial issue. We studied 129 colorectal carcinomas that arose in adenomas and in which invasion was no deeper than the submucosa of the underlying colonic wall.

Cerebromicrocirculatory defects in animal model of depression.

In the tetrabenazine (TBZ) model of depression, the cerebromicrocirculation was discovered to respond abnormally to metabolic demand as mimicked by the administration of CO2. Altered responsivity of cerebral blood flow and effective permeability of the blood--brain barrier to changes in PaCO2 were found. These physiologic defects coincided temporally with TBZ-induced depletion of central norepinephrine and dopamine and with the development of the behavioral effects of TBZ (the end points used to test the antidepressant potential of experimental drugs).

Aspergillus terreus infection of pseudoaneurysm of aortofemoral vascular graft with contiguous vertebral osteomyelitis.

This is a case report of a patient who developed several unusual complications of an aortofemoral vascular graft. These were thrombosis, pseudoaneurysm, and infection. There was an Aspergillus terreus infection of the pseudoaneurysm of the vascular prosthesis.

Cimetidine-induced thrombocytopenia.

This report described a case of cimetidine-induced thrombocytopenia documented by accidental rechallenge. With the increasing use of cimetidine, especially in patients with complicated problems that predispose to gastrointestinal blood loss, it is important to recognize thrombocytopenia as one of the possible side effects of cimetidine therapy and to monitor platelet studies frequently.

Brain concentrations of tricyclic antidepressants: single-dose kinetics and relationship to plasma concentrations in chronically dosed rats.

A previously reported method of measuring tricyclic antidepressant concentrations in brain tissue and plasma was used to measure amitriptyline (AMI) in rats following drug administration using different routes, doses, and time intervals. In rats given AMI intraperitoneally (IP), brain concentrations increased during the first 30 min after drug administration and then declined. Brain concentrations increased linearly with changes in IP dosage and increased logarithmically with changes in intravenous dosage.

A liquid chromatographic method for quantitating amitriptyline in brain tissue.

A previously reported method for measuring tricyclic antidepressants (TCA) in plasma was modified to measure TCA, specifically amitriptyline (AMI) and nortriptyline (NOR) in rat brain tissue. Brains obtained from drug-free and AMI-treated rats were extracted and assayed using a Waters high-performance liquid chromatograph. Drug-free brain tissue contained no substances which interfered with the assay of these TCAs.

Systemic embolization as a complication of transhepatic venography.

Many patients with cirrhosis and portal hypertension demonstrate a right-to-left shunt, caused by development of anastomoses connecting the high-pressure periesophageal veins with the low-pressure bronchial and/or pulmonary veins at the level of the pulmonary hili. These anastomoses from the pathway by which small Gelfoam particles injected into the coronary or short gastric veins may embolize the systemic arterial circulation. Such embolization could have serious consequences, but reports of such complications have not been found by the authors.