Early detection of gastric cancer using global, genome-wide and IRF4, ELMO1, CLIP4 and MSC DNA methylation in endoscopic biopsies.

Clinically useful molecular tools to triage gastric cancer patients are not currently available. We aimed to develop a molecular tool to predict gastric cancer risk in endoscopy-driven biopsies obtained from high-risk gastric cancer clinics in low resource settings.We discovered and validated a DNA methylation biomarker panel in endoscopic samples obtained from 362 patients seen between 2004 and 2009 in three high-risk gastric cancer clinics in Lima, Perú, and validated it in 306 samples from the Cancer Genome Atlas project ("TCGA").

Cuticular extracts from Acromis sparsa (Coleoptera: Cassidinae) mediate arrestment behavior of the commensal canestriniid mite Grandiella rugosita.

Astigmatid mites in the family Canestriniidae are often closely associated with tortoise leaf beetles (Chrysomelidae: Cassidinae). For example, the survival of the commensal canestriniid mite Grandiella rugosita depends on dispersal to the cassidine beetle Acromis sparsa. Here, we tested whether the beetle cuticle provides chemical cues for host recognition for G.

Socioeconomic and nutritional factors account for the association of gastric cancer with Amerindian ancestry in a Latin American admixed population.

Gastric cancer is one of the most lethal types of cancer and its incidence varies worldwide, with the Andean region of South America showing high incidence rates. We evaluated the genetic structure of the population from Lima (Peru) and performed a case-control genetic association study to test the contribution of African, European, or Native American ancestry to risk for gastric cancer, controlling for the effect of non-genetic factors. A wide set of socioeconomic, dietary, and clinic information was collected for each participant in the study and ancestry was estimated based on 103 ancestry informative markers.

The allometry of CNS size and consequences of miniaturization in orb-weaving and cleptoparasitic spiders.

Allometric studies of the gross neuroanatomy of adults from nine species of spiders from six web-weaving families (Orbicularia), and nymphs from six of these species, show that very small spiders resemble other small animals in having disproportionately larger central nervous systems (CNSs) relative to body mass when compared with large-bodied forms. Small spiderlings and minute adult spiders have similar relative CNS volumes. The relatively large CNS of a very small spider occupies up to 78% of the cephalothorax volume.

Interleukin-1 beta single-nucleotide polymorphism's C allele is associated with elevated risk of gastric cancer in Helicobacter pylori-infected Peruvians.

Particular alleles of the interleukin-1B (IL-1B) gene have been correlated with increased risk of atrophic gastritis and gastric cancer in the populations of East Asia and Europe. No such data exist from Peru, a developing country with a population genotypically different from others studied and with a high prevalence of Helicobacter pylori infection and gastric cancer. We conducted a case-control study comparing 334 hospitalized patients with atrophic gastritis or gastric cancer with 158 nonatrophic gastritis patients (controls).

[Optimal age for gastric cancer screening in patients with dyspepsia without alarm symptoms].

Objective: To determine the optimal age for screening endoscopy on patients with dyspepsia without alarm symptoms to avoid missing gastric cancer.

Methods: A Cross sectional study was performed (2001-2005). 285 cases of patients with dyspepsia and gastric cancer were found at Arzobispo Loayza National Hospital.

[Viral Hepatitis A over imposed on chronic hepatic damage due to tamoxifen: report of a case].

A case of Hepatitis A is reported in a patient prescribed tamoxifen after surgery for breast cancer and taking tamoxifen 20 mg/day for two and a half years. Documented is the indirect development of Hepatitis A and tamoxifen-induced hepatic damage.

Soda consumption and overweight status of 2-year-old mexican-american children in california.

Objective: The prevalence of overweight in United States children, 2 to 5 years old, has increased 2-fold since 1975, with the highest prevalence in Mexican Americans. The objective of this study was to determine the association between current soda consumption and overweight in 2-year-old Mexican-American children.

Research Methods And Procedures: The Center for the Health Assessment of Mothers and Children of Salinas study is a longitudinal study of the health of low-income Latino pregnant women and their children living in the Salinas Valley, CA.

[Colestasic toxic hepatitis caused by terbinafine: case report].

Trichophytic onychomycosis of the feet represents an important and serious medical problem. Until recent years, there was not cure for this unpleasant pathology. It is only at the beginning of the 50s, especially at the onset of the antimycotic systemic therapy that a cure is available offering high rate of clinical and mycological therapy.

[RETROGRADE ENDOSCOPIC CHOLANGIO PANCREOTOGRAPHY(PCRE)AND PAPILLOSPHINCTERECTOMY: A REPORT ON TWO CASES].

We report two paediatric patients diagnosed with Cholellithiasis and Choledocolithiasis who underwent Laparoscopic Cholecystectomy and Papillosphincterectomy.

[HEPATIC AMYLOIDIOSIS: REPORT OF ONE CASE].

We present a case of a 62-year old patient with systemic amyloidosis. The conclusive diagnosis was made by liver biopsy. The most important features of the disease, diagnosis, treatment, and prognosis were reviewed.

[HEPATIC HYDATIC CYST ASSOCIATED WITH PORTAL HYPERTENSION].

We report the case of a 26-year-old woman from Cerro of Pasco - Per , with hydatid cyst in the liver associated with portal hypertension. We know that the echinococcosis in the liver is usually asymptomatic, although can produce clinical features that depend of the size and localization in the liver. The clinical, radiological and endoscopic findings are presented, due to the uncommon presentation and the few cases reported in the literature about this asociation

[PREGNANCY AND HEPATITIS CIRRHOSIS].

We report a case of a pregnant woman of 33 years old, suffering from hepatic cirrhosis by Hepatitis B with splenomegaly and portal hypertension, the 40 weeks pregnancy ended succesfully with a newborn weighting 2,900 g born by vaginal delivery.

[MYCOBACTERIUM AVIUM INTRACELLULAR DUODENITIS IN AN AIDS PATIENTS].

Mycobacterium avium Intracellulare is a significant pathogen in immunocompromised patients.We present a male patient, 37 years old, HIV(positive) since 1998 with clinical history of chronic diarrhea and weigth loss. On December 1999 he was seen on the Gastroenterology service of Arzobispo Loayza Hospital.

[CLINICAL AND IMMUNOLOGICL PROFILE IN 22 PATIENTS WITH PRIMARY BILIARY CIRRHOSIS].

The primary biliary cirrhosis (PBC) is a no frequent entity in our country. Its diagnosis is based on clinical features, cholestasic pattern in liver function tests and the presence of antimitochondrial antibody in 90% of cases and other auto-antibodies in the serum, all this information is supported by characteristic hepatic histopathologic data. Also some clinical variants have been described that has suggested different denominations such as Overlap Syndrome, associated to autoimmune hepatitis and autoimmune colangitis, known by its persistent negativity of the antimitochondrials antibodies.

[PREGNANCY AND LIVER CIRRHOSIS: REPORT OF A CASE].

Pregnancy in women with liver cirrhosis is unusual, because of the metabolic alterations that the liver disease produces.We report a case of a cirrhotic alcoholic patient who was pregnant twice. The first pregnancy was successful delivering a baby of 2,500g.