Publications by authors named "Gloria P Larson"
ADP-ribosylation is a highly dynamic and fully reversible post-translational modification performed by poly(ADP-ribose) polymerases (PARPs) that modulates protein function, abundance, localization and turnover. Here we show that influenza A virus infection causes a rapid and dramatic upregulation of global ADP-ribosylation that inhibits viral replication. Mass spectrometry defined for the first time the global ADP-ribosylome during infection, creating an infection-specific profile with almost 4,300 modification sites on ~1,080 host proteins, as well as over 100 modification sites on viral proteins.
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- The ongoing evolution of SARS-CoV-2 has led to new variants that heighten the severity of the COVID-19 pandemic, classified as variants of concern or interest (VOC/VOI) due to their impact on vaccine effectiveness.
- A study analyzing 14 different variants found varying levels of resistance to neutralization by antibodies from vaccinated individuals, with the Omicron variant being the most adept at evading these defenses.
- Despite Omicron's escape ability, individuals who received a booster vaccination still showed moderate effectiveness in neutralizing this variant, reinforcing the importance of vaccination in combating COVID-19.
All viruses balance interactions between cellular machinery co-opted to support replication and host factors deployed to halt the infection. We use gene correlation analysis to perform an unbiased screen for host factors involved in influenza A virus (FLUAV) infection. Our screen identifies the cellular factor epidermal growth factor receptor pathway substrate 8 (EPS8) as the highest confidence pro-viral candidate.
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