Publications by authors named "Gloria Giovanna Del Vescovo"
Diagnosis of Latent Autoimmune Diabetes in Adults (LADA) is based on the adult-age, anti-islet autoantibodies, and temporary insulin-independence. As in Type-1-Diabetes (T1DM), autoimmunity may trigger LADA and enteroviruses-infections can play a role. Anti-human Glutamic-Acid-Decarboxylase (hGAD) autoantibodies are accepted clinical biomarkers, but do not discriminate LADA T1DM.
View Article and Find Full Text PDFCross-reactive peptide epitopes of Enterovirus Coxsackie B4 and human glutamic acid decarboxylase detecting antibodies in latent autoimmune diabetes in adults versus type 1 diabetes.
Clin Chim Acta
April 2021
Article Synopsis
- The study investigates the diagnostic potential of antibodies against human glutamic acid decarboxylase (hGAD) peptides in diagnosing latent autoimmune diabetes in adults (LADA) and type 1 diabetes mellitus (T1DM), focusing on their relation to Enterovirus Coxsackie B4.
- It involved testing serum samples from 27 LADA patients, 23 T1DM patients, and 24 controls using ELISA, and found significant differences in antibody responses between the patient groups and the controls.
- The results showed that IgM antibodies had high diagnostic power for LADA (sensitivity over 85%, specificity 95.8%), highlighting the importance of peptide antigens in distinguishing between T1DM and L
Genetics and Epigenetics: New Insight on Gestational Diabetes Mellitus.
Front Endocrinol (Lausanne)
May 2021
Gestational diabetes mellitus (GDM) is the most common metabolic complication of pregnancy, with a prevalence that has increased significantly in the last decade, coming to affect 12-18% of all pregnancies. GDM is believed to be the result of a combination of genetic, epigenetic and environmental factors. Following the identification of susceptibility genes for type 2 diabetes by means of genome-wide association studies, an association has also been demonstrated between some type 2 diabetes susceptibility genes and GDM, suggesting a partial similarity of the genetic architecture behind the two forms of diabetes.
View Article and Find Full Text PDFAim: Gestational diabetes mellitus (GDM) and celiac disease, if not diagnosed and properly treated, are associated with adverse outcomes of pregnancy. The aim of our study was to examine pregnancies complicated by GDM in celiac and nonceliac women in terms of their metabolic parameters and maternal and fetal outcomes.
Methods: The study involved 60 women with GDM, 20 with and 40 without celiac disease.
Aim: The aim of this study was to examine attendance for early postpartum follow-up among women with gestational diabetes mellitus (GDM), and to identify factors that influenced their likelihood of attending.
Methods: One thousand eight hundred and nineteen women with GDM were retrospectively analyzed. During pregnancy, the following data were collected: age, family history of diabetes, ethnicity, prepregnancy BMI, fasting plasma glucose, glycated hemoglobin, gestational week of GDM diagnosis, timing and mode of delivery, newborn's birth weight and length.