[Collagenous colitis. Studies on the differentiation and incidence of the syndrome].

All colon biopsy specimens of 28 months collected in an institute of pathology, providing a region of 660,000 inhabitants were reviewed for thickening of the subepithelial layer above the normal range of 7 mu. 16 cases were found, eleven of them with mild, uncharacteristic symptoms, eight even without diarrhea. Of the five cases with collagen layers above 10 mu, three suffered from intestinal diseases (unspecific protocolitis, active ulcerative colitis and malabsorption after ileum resection); two showed chronic diarrhea as symptoms of collagenous colitis.

The radioimmunological determination of glibenclamide and its metabolites in serum.

This report describes a sensitive and specific radio-immunological method for determining serum levels of the oral anti-diabetic agent 1-(p-[2-(5-chloro-2-methoxy-benzamido)-ethyl]-benzensulfonyl)-3-cyclohexylurea (glibenclamide) and its metabolites. The antigen was prepared by coupling a metabolite to bovine serum albumin. Antibodies could be demonstrated in serum after immunisation of rabbits.

[Clinical and diagnostical aspects of acute cytomegalovirus infections in previously healthy adults (author's transl)].

The clinical symptoms of floride Cytomegalovirus infections of 18 previously healthy adults are reported. Fever was generally observed. In most cases myocarditis or hepatitis could be identified.

[Elimination kinetics of phenprocoumon (Marcumar) in liver cirrhosis and after premedication with phenobarbital].

In this paper are presented the results of a study on the elimination kinetics of phenprocoumon in patients concomitantly treated with phenprocoumon and phenobarbital as well as in patients with bioptically proved hepatic cirrhosis. The pre-treatment of the patients with phenobarbital (3 X 100 mg), 4 days before phenprocoumon was started, resulted in an accelerated elimination of phenprocoumon. The biological half-life of phenprocoumon was reduced from 150 to 70 hrs when compared to normal controls, and the elimination constant was found to increase to 9,96 X 10(-3).

Pharmacokinetics of phenprocoumon in man investigated using a gas chromatographic method of drug analysis.

A gas chromatographic method for the determination of phenprocoumon (Marcumar) in serum and urine is described, which facilitates accurate values down to 0.5 mug phenprocoumon/ml serum. After the i.

[Hydroxylation of glibenclamide by liver biopsy specimens].

A method for measuring hydroxylation rates of the oral antidiabetic agent glibenclamide (Euglucon) by liver biopsy specimens is described. After incubation of the material in a buffer system, containing glibenclamide-14-C, the supernatant is extracted with organic solvent. The extract is condensed and the radioactivity of the spots after thin-layer chromatography is measured.