Publications by authors named "Glikson M"
Objective: This study sought to present the endovascular approach of transcatheter aspiration using the FlowTriever (Inari Medical) aspiration system for high surgical risk patients with right-sided infective endocarditis.
Key Steps: General anesthesia and transesophageal echocardiogram guidance; ultrasonography-guided femoral vein access, preclosure sutures, and insertion of a 24-F sheath; insertion of straight 24-F aspiration cannula over a stiff wire, parked in the superior vena cava; introduction of a 20-F curved cannula inside the 24-F cannula to create a telescopic assembly; accurate positioning using the right ventricle inflow/outflow projection in biplane mode; adjustment of the curved cannula radius by sliding the inner cannula in and out inside the mother cannula; manual aspiration of the vegetation; Postaspiration transesophageal echocardiogram assessment.
Potential Pitfalls: Avoid leaflet and annular injury and account for potential embolization.
The role of multi-modality imaging for the assessment of left atrium and left atrial appendage. A clinical consensus statement of the European Association of Cardiovascular Imaging (EACVI), European Heart Rhythm Association (EHRA) of the European Society of Cardiology (ESC).
Eur Heart J Cardiovasc Imaging
January 2025
Structural, architectural, contractile or electrophysiological alterations may occur in the left atrium (LA). The concept of LA cardiopathy is supported by accumulating scientific evidence demonstrating that LA remodeling has become a cornerstone diagnostic and prognostic marker. The structure and the function of LA and left atrial appendage (LAA) which is an integral part of the LA, are key elements for a better understanding of multiple clinical conditions, most notably atrial fibrillation (AF), cardioembolism, heart failure and mitral valve diseases.
View Article and Find Full Text PDFIntroduction: Cardiac troponin I is routinely measured in patients with suspected acute coronary syndrome. However, when a high-sensitivity cardiac troponin I (hs-cTnI) test is ordered without a clear clinical indication, unexpectedly elevated levels can lead to unnecessary diagnostic workups and inappropriate management. This study aimed to investigate physicians' rationale for performing hs-cTnI tests in an emergency department (ED).
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- Ventricular arrhythmias (VAs) are uncommon but can occur after electrical cardioversion (ECV) for atrial fibrillation (AF), with an incidence of about 0.2% based on a study of nearly 12,000 ECV procedures.
- The study involved 23 patients who experienced VAs within 10 days of ECV, with most cases developing 28.5 hours after the procedure, and a significant number had underlying health issues like congestive heart failure.
- The findings suggest that while VAs post-ECV are rare, they can be life-threatening, especially in patients with certain risk factors, indicating that careful monitoring is essential for these individuals.
Article Synopsis
- Platelets have a significant impact on aortic stenosis (AS) and patients undergoing transcatheter aortic valve implantation (TAVI), prompting an analysis of their indices in relation to AS stages.
- In a study involving 220 TAVI patients, they were categorized into 5 AS stages based on cardiac damage, revealing a correlation between higher mean platelet volume (MPV) and advanced AS staging, as well as lower hemoglobin levels.
- The findings indicate that while MPV and immature platelet fraction (IPF) show variations across stages, only MPV and body mass index (BMI) were significant predictors of higher AS staging in the logistic regression analysis.
Article Synopsis
- * Scoring systems like the MADIT Risk Stratification Score (MRSS) and Seattle Heart Failure Model (SHFM) help identify which patients might have better survival benefits from ICDs, based on studies involving real-world heart failure patients.
- * Although these scoring systems aren't fully ready for clinical use, they can inform decisions on ICD implantation, especially for high-risk elderly patients or those with multiple health issues, while cardiac MRI can identify heart scar areas linked to arrhythmias.
Article Synopsis
- - The study investigates the relationship between peak high-sensitivity cardiac troponin (hs-cTn) levels and one-year mortality in patients admitted to intensive cardiovascular care units (ICCU) from 2019 to 2023.
- - A total of 4149 patients were analyzed, revealing that those with hs-cTnI levels ≥100,000 ng/L had a significantly higher risk of mortality compared to lower levels, particularly in non-ST elevation myocardial infarction (NSTEMI) cases.
- - The findings suggest that while high hs-cTnI levels indicate poor prognosis, the impact on mortality rates varies notably between patients with ST elevation myocardial infarction (STEMI) and NSTEMI, indicating a need
Introduction: Renal failure associated aortic valve calcification (AVC) is the result of hyperphosphatemia and hyperparathyroidism. Calcimimetics is an effective tool for management of secondary hyperparathyroidism. Our goal was to evaluate the effect of the medical intervention with calcimimetic R568 on the AVC process.
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- * Analyzed outcomes between patients who received imaging and those who did not, finding no significant differences in complications, recurrence of atrial fibrillation, or re-hospitalization rates after one year.
- * Despite longer procedure times for those who underwent imaging (90 minutes vs. 74.5 minutes), the study concludes that pre-procedural imaging does not impact the safety or efficacy of PVI in managing atrial fibrillation.
Article Synopsis
- A study was conducted to evaluate the success and outcomes of electroanatomical-guided cardioneuroablation (EACNA) in treating patients with vagally induced atrioventricular blocks (VAVBs).
- The results showed a high acute procedural success rate of 96.2%, but 14% of patients experienced recurrence of AVB or new syncopal episodes during a follow-up period of approximately 300 days.
- The findings suggest that EACNA is a promising option for patients with VAVB, but further research is needed to explore its effects on daytime symptom burden.
Article Synopsis
- - The text discusses Calcium Release Deficiency Syndrome (CRDS), a serious genetic heart condition that can cause sudden cardiac arrest without clear reasons and is not detectable through standard tests.
- - The study aimed to analyze electrocardiogram (ECG) responses after brief periods of fast heart rates followed by pauses in order to develop a diagnostic test for CRDS.
- - Findings showed that patients with CRDS had a significantly greater change in T-wave amplitude on their ECG after a pause compared to control groups, indicating a potential diagnostic marker for this syndrome.
Article Synopsis
- The study focuses on the effectiveness of transcatheter edge-to-edge repair (TEER) for patients with mitral regurgitation (MR), specifically examining pulmonary venous (PV) flow as an indicator of heart valve function.
- Researchers analyzed data from 80 consecutive MR patients who underwent TEER, measuring PV flow parameters before and after the procedure, and evaluated their relationship with heart failure hospitalizations (HFH) and mortality rates over one year.
- Results showed significant improvements in PV flow following the TEER procedure, indicating that better hemodynamic parameters were linked to lower risks of heart failure and mortality, highlighting the potential of PV flow analysis as a useful tool for assessing TEER outcomes.
Article Synopsis
- The study investigates the incidence of fatal heart complications, specifically ventricular fibrillation (VF) and sustained ventricular tachycardia (VT), in patients with non-ST elevation myocardial infarction (NSTEMI) admitted to an intensive coronary care unit (ICCU).
- Out of 732 NSTEMI patients monitored, only three (0.4%) developed VF/VT during their stay, with none of the patients experiencing mortality in a year following treatment.
- The findings indicate that VF/VT occurrences in NSTEMI patients under current treatment guidelines are infrequent, suggesting that routine ICCU monitoring may not be necessary for these patients.
Article Synopsis
- This study focused on patients with acute myocarditis (AM) who experienced ventricular arrhythmia (VA), aiming to identify how common sustained VA recurrence and mortality are, as well as what factors might predict these outcomes.* -
- A total of 69 AM patients with documented VA were analyzed, revealing that during a median follow-up of 5.5 years, about 39% faced significant health issues including sustained VA or death, with specific predictors like initial monomorphic ventricular tachycardia (MMVT) and impaired heart function being particularly important.* -
- The research suggests that identifying these predictors can help stratify patients into low, medium, and high-risk groups for complications over a decade, thus informing treatment strategies for those
Article Synopsis
- Point-of-care ultrasound is widely used by physicians to aid in diagnostics, particularly in assessing left-ventricular ejection fraction (LVEF) in patients.
- A study involving trained medical students used an AI tool to evaluate LVEF in hospitalized patients, finding that reduced LVEF was linked to higher rates of mortality and readmission for cardiovascular issues.
- The results suggest that even novice users, like medical students, can leverage AI in ultrasound assessments to predict patient outcomes and identify those at higher risk for complications.
Article Synopsis
- The study investigates how the Israel-Hamas war in 2023 impacted cardiovascular health, focusing on the admissions and outcomes in a specialized cardiac care unit.
- Researchers analyzed data from 556 patients admitted during the war's initial three months and compared it to a similar timeframe in 2022.
- The findings showed a decline in Arab patient admissions and an increase in STEMI cases during the war, yet the overall in-hospital mortality rates remained comparable between the two periods.
Importance: Rapid reperfusion during primary percutaneous coronary intervention (PCI) is associated with improved outcomes among patients with ST-elevation myocardial infarction (STEMI). Although attempts at reducing the time from STEMI diagnosis to arrival at the catheterization laboratory have been widely investigated, intraprocedural strategies aimed at reducing the time to reperfusion are lacking.
Objective: To evaluate the effect of culprit lesion PCI before complete diagnostic coronary angiography (CAG) vs complete CAG followed by culprit lesion PCI on reperfusion times among patients with STEMI.
Article Synopsis
- A study was conducted to explore sex differences in in-hospital mortality rates among patients with acute coronary syndrome (ACS), highlighting that women face higher mortality and complications despite efforts to reduce sex bias in treatment.
- The research involved analyzing data from 2,346 ACS patients, with a focus on 453 female patients, who showed greater prevalence of non-ST elevation myocardial infarction (NSTEMI) and longer wait times for urgent procedures compared to males.
- The study developed predictive models using artificial intelligence, finding that the gradient boosting classifier performed best in predicting in-hospital mortality, indicating age, type of myocardial infarction, and inflammatory markers as key risk factors.
Article Synopsis
- * It focuses on the CNA-FWRD Registry, a multicenter prospective study that compares outcomes between patients receiving standard therapy and those undergoing cardioneuroablation over a follow-up period of three years.
- * The findings aim to provide valuable data on long-term effects, recurrence of symptoms, and overall safety of cardioneuroablation, addressing a gap in existing research which is largely based on retrospective studies.
Atherosclerosis is an insidious and progressive inflammatory disease characterized by the formation of lipid-laden plaques within the intima of arterial walls with potentially devastating consequences. While rupture of vulnerable plaques has been extensively studied, a distinct mechanism known as plaque erosion (PE) has gained recognition and attention in recent years. PE, characterized by the loss of endothelial cell lining in the presence of intact fibrous cap, contributes to a significant and growing proportion of acute coronary events.
View Article and Find Full Text PDFIntroduction: Immature platelets or reticulated platelets are newly released thrombocytes. They can be identified by their large size and high RNA cytoplasm concentration. Immature platelet fraction (IPF) represents the percentage of immature circulative platelets relative to the total number of platelets.
View Article and Find Full Text PDFBackground: The PRAETORIAN score estimates the risk of failure of subcutaneous implantable cardioverter-defibrillator (S-ICD) therapy by using generator and lead positioning on bidirectional chest radiographs. The PRospective randomized compArative trial of subcutanEous implanTable cardiOverter-defibrillatoR ImplANtation with and without DeFibrillation Testing (PRAETORIAN-DFT) investigates whether PRAETORIAN score calculation is noninferior to defibrillation testing (DFT) with regard to first shock efficacy in spontaneous events.
Objective: This prespecified subanalysis assessed the predictive value of the PRAETORIAN score for defibrillation success in induced ventricular arrhythmias.
Article Synopsis
- The study aimed to investigate the incidence and significance of isolated PR prolongation (IPRP) after transcatheter aortic valve implantation (TAVI), particularly without accompanying QRS changes on ECG.
- Out of 1108 patients, 146 exhibited IPRP, and their clinical outcomes, including the need for pacemakers and overall mortality, were compared with 290 patients without ECG changes post-TAVI.
- Results indicated that IPRP in patients with narrow QRS was not linked to negative outcomes, suggesting that doctors may take a more lenient approach toward treating these patients.