Development of an acute, short-term exposure model for phosgene.

Phosgene is classified as a chemical warfare agent, yet data on its short-duration high concentration toxicity in a nose-only exposure rat model is sparse and inconsistent. Hence, an exposure system for short-term/high concentration exposure was developed and characterized. Herein, we report the median lethal concentration (LC) for a 10-min nasal exposure of phosgene in a 24-h rat survival model.

Cardioprotective Effects of HSP72 Administration on Ischemia-Reperfusion Injury.

Background: Although early reperfusion is the most desirable intervention after ischemic myocardial insult, it may add to damage through oxidative stress.

Objectives: This study investigated the cardioprotective effects of a single intravenous dose of heat shock protein-72 (HSP72) coupled to a single-chain variable fragment (Fv) of monoclonal antibody 3E10 (3E10Fv) in a rabbit ischemia-reperfusion model. The Fv facilitates rapid transport of HSP72 into cells, even with intact membranes.