Publications by authors named "Glenda Vasku"
Article Synopsis
- * The study identified around 500 lipid species in human blood and eye tissues using a combination of hydrophilic interaction liquid chromatography (HILIC) and reversed-phase chromatography (RPC), along with high-resolution mass spectrometry.
- * While RPC was better at detecting hydrophobic lipids, HILIC excelled in separating polar lipids; using both methods together enhanced the analysis of lipid classes, providing valuable insights into lipid metabolism and its implications for diseases.
Rapid Analysis of Plasmalogen Individual Species by High-Resolution Mass Spectrometry.
Methods Mol Biol
January 2023
Analysis and quantification of ether-lipid phospholipid species-also known as plasmalogens-is a crucial step in the study of the biological functions played by these lipids. Application of analytical separation methods and high-resolution mass spectrometry has gained much attention in this regard, while resolution issues and time-consuming sequences interfered with these advances. Herein, we describe a simple and rapid method for the analysis of plasmalogen (Pl) species by HILIC-HRMS.
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- This study aimed to investigate the effects of docosahexaenoic acid (DHA) as an antifibrotic treatment following glaucoma filtration surgery (GFS) in rats.
- The experiment included 36 rats divided into three groups: a control group, a DHA group, and a mitomycin C (MMC) group, with measurements of intraocular pressure (IOP) and observed changes in fibroblast activity.
- Results showed that both the DHA and MMC groups maintained lower IOP and larger bleb areas compared to the control group, indicating that DHA has potential similar effects to MMC, warranting further research.