Publications by authors named "Glenda Quan"

Article Synopsis
  • The study aimed to create a predictive tool to determine which patients with mild traumatic brain injury (mTBI) and subdural hematoma (SDH) may need neurosurgical intervention, as current methods are unreliable and lead to unnecessary treatments.
  • Conducted across six trauma centers, the research analyzed 1,333 patients admitted between 2016 and 2020, using variables like hematoma thickness and Glasgow Coma Scale scores to inform predictions.
  • Results showed a neurosurgical intervention rate of 8.8%, with key factors identified for predicting surgical need while maintaining a sensitivity of 100%.
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Article Synopsis
  • The study aimed to identify risk factors for immediate neurosurgical intervention in patients with mild traumatic brain injuries and isolated subdural hematomas, using data from 6 trauma centers over a 5-year period.
  • Out of 1333 patients, 117 (8.8%) required surgery within 48 hours, with significant predictors being demographic factors like sex and mechanism of injury, as well as radiographic details like hemorrhage thickness and midline shift.
  • Ultimately, the combined analysis highlighted that advanced directives, Injury Severity Score, midline shift, and maximum hemorrhage thickness were crucial indicators for determining the need for surgical intervention shortly after hospital admission.
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Background: The COVID-19 pandemic has impacted the residency experience for physicians across all specialties. There have been studies examining resident perspectives on changes in curriculum and clinical experiences due to the pandemic; however, little research has been conducted on how residents in different specialties interpreted their educational experience and rates of burnout during the pandemic.

Methods: We extended surveys to 281 residents across 15 separate residency programs between November 17, 2020, and December 20, 2020.

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Background: There is an epidemic of firearm injuries in the United States since the mid-2000s. Thus, we sought to examine whether hospitalization from firearm injuries have increased over time, and to examine temporal changes in patient demographics, firearm injury intent, and injury severity.

Methods: This was a multicenter, retrospective, observational cohort study of patients hospitalized with a traumatic injury to six US level I trauma centers between 1/1/2016 and 6/30/2022.

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There have been large changes over the past several decades to patient demographics in those presenting with mild traumatic brain injury (mTBI) with intracranial hemorrhage (ICH; complicated mTBI) with the potential to affect the use of neurosurgical interventions. The objective of this study was to characterize long-term trends of neurosurgical interventions in patients with complicated mTBI using 13 years of the National Trauma Data Bank (NTDB). This was a retrospective cohort study of adult (≥18 years) trauma patients included in the NTDB from 2007 to 2019 who had an emergency department Glasgow Coma Scale score 13-15, an intracranial hemorrhage (ICH), and no skull fracture.

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The objective of this study was to quantify nation-wide interhospital variation in neurosurgical intervention risk by intracranial hemorrhage (ICH) type in the setting of mild traumatic brain injury (mTBI). This was a retrospective cohort study of adult (≥18 years) trauma patients included in the National Trauma Data Bank from 2007 to 2019 with an emergency department Glasgow Coma Scale score 13-15, diagnosed ICH, no skull fracture. The primary outcome was neurosurgical intervention.

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We present a 76-year-old male who presented to the emergency department with 24 hours of sudden onset, severe abdominal pain. Physical exam and laboratory analysis indicated acute cholecystitis, and a CT scan demonstrated a ventral hernia containing an inflamed gallbladder. This patient was managed operatively with an open cholecystectomy.

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Background: Damage control laparotomy (DCL) is a life-saving procedure in patients with abdominal hemorrhage. After DCL, patients are sometimes left with an open abdomen (OA) so they may undergo multiple exploratory laparotomies (EXLAP), or re-explorations. Patients with OA are at increased risk of infectious complications (ICs).

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Introduction: Treatment resistance, long latency, and high recurrence rates suggest that breast cancers arise from defective breast stem cells.

Hypothesis: Within cancers, subpopulations of cells will demonstrate differences in stem/progenitor potential, HER2/neu amplification, and gene expression. Related cells will be found in normal breast tissue.

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Stereotactic biopsy has proven more cost effective for biopsy of lesions associated with moderately suspicious mammograms. Data regarding selection of stereotactic biopsy (CORE) instead of excisional biopsy (EB) as the first diagnostic procedure in patients with nonpalpable breast lesions and highest suspicion breast imaging-reporting and data system (BI-RADS)-5 mammograms are sparse. Records from a regional health system radiology database were screened for mammograms associated with image-guided biopsy.

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Background: The significance of a contralateral breast cancer is largely unknown, making prophylactic mastectomy controversial.

Methods: Differences between stages of initial and contralateral cancers were determined by t test. Survival distributions were compared by log-rank analyses and compared with Surveillance Epidemiology and End Results data for unilateral cancers.

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Chromosome 19 has the highest gene density of all human chromosomes, more than double the genome-wide average. The large clustered gene families, corresponding high G + C content, CpG islands and density of repetitive DNA indicate a chromosome rich in biological and evolutionary significance. Here we describe 55.

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