The effects of intradermal and topical mitomycin C on wound healing.

Objective: To determine the effect of intradermal and topical mitomycin C (MMC) on skin wound healing.

Study Design/setting: A prospective, controlled study in a rat wound model performed in an academic medical center.

Results: Intradermal and topical MMC application decreased wound integrity when compared with saline-treated animals at 1 week, 2 weeks, 1 month, and 6 months.