Publications by authors named "Glen J Bubley"
Article Synopsis
- The study investigates the efficacy and toxicity of combining RAD001 (a mTOR inhibitor) with bicalutamide in treating castration-resistant prostate cancer (CRPC), aiming to provide insight into treatment response and safety profiles.
- The research highlights the ongoing challenge of drug resistance in CRPC, stressing the importance of understanding the interaction between androgen receptor and PI3K-Akt-mTOR pathways in the context of newer treatment strategies.
- Although the trial reported low efficacy results, it offers valuable data that could influence the development and testing of future AR and PI3K-Akt-mTOR inhibitors in CRPC therapies.
