The effect of increased serotonergic neurotransmission on aggression: a critical meta-analytical review of preclinical studies.

Rationale: The role of serotonin (5-HT) on aggression has been extensively studied; nonetheless, the role of this neurotransmitter in aggression is still inconclusive.

Objectives: The current meta-analytical review investigated the role of increased 5-HT neurotransmission in aggression.

Methods: Preclinical studies using serotonin reuptake inhibitors, 5-hydroxytryptophan, L-tryptophan, or serotonin (5-HT) to increase 5-HT levels were included in this meta-analysis.